Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Anders E. Berglund"'
Publikováno v:
Cells, Vol 13, Iss 11, p 942 (2024)
Glioblastoma (GBM) is the most common yet uniformly fatal adult brain cancer. Intra-tumoral molecular and cellular heterogeneities are major contributory factors to therapeutic refractoriness and futility in GBM. Molecular heterogeneity is represente
Externí odkaz:
https://doaj.org/article/323f63e52c5e445a91184b6a164dfa89
Autor:
Ravneet Chhabra, Jennifer Guergues, Jessica Wohlfahrt, Stephanie Rockfield, Pamela Espinoza Gonzalez, Shanon Rego, Margaret A. Park, Anders E. Berglund, Stanley M. Stevens, Meera Nanjundan
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Clear cell renal cell carcinomas (ccRCC) are characterized by arm-wide chromosomal alterations. Loss at 14q is associated with disease aggressiveness in ccRCC, which responds poorly to chemotherapeutics. The 14q locus contains one of the largest miRN
Externí odkaz:
https://doaj.org/article/93daa7f86ba544acbc92b9d6f31f861c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15179 (2023)
Temozolomide (TMZ) is an important first-line treatment for glioblastoma (GBM), but there are limitations to TMZ response in terms of durability and dependence on the promoter methylation status of the DNA repair gene O6-methylguanine DNA methyltrans
Externí odkaz:
https://doaj.org/article/0973be1d4bf54097acab72ef804d8917
Autor:
Hui-Yi Lin, Po-Yu Huang, Chia-Ho Cheng, Heng-Yuan Tung, Zhide Fang, Anders E. Berglund, Ann Chen, Jennifer French-Kwawu, Darian Harris, Julio Pow-Sang, Kosj Yamoah, John L. Cleveland, Shivanshu Awasthi, Robert J. Rounbehler, Travis Gerke, Jasreman Dhillon, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, UKGPCS collaborators, Johanna Schleutker, Nora Pashayan, APCB (Australian Prostate Cancer BioResource), David E. Neal, Sune F. Nielsen, Børge G. Nordestgaard, Henrik Gronberg, Fredrik Wiklund, Graham G. Giles, Christopher A. Haiman, Ruth C. Travis, Janet L. Stanford, Adam S. Kibel, Cezary Cybulski, Kay-Tee Khaw, Christiane Maier, Stephen N. Thibodeau, Manuel R. Teixeira, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Hardev Pandha, The PRACTICAL consortium, Srilakshmi Srinivasan, Judith Clements, Jyotsna Batra, Jong Y. Park
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP–SNP interactio
Externí odkaz:
https://doaj.org/article/e04a68afd0214bb2aaaa455915e1fc0c
Autor:
Saurabh K. Garg, Matthew J. Ott, A. G. M. Mostofa, Zhihua Chen, Y. Ann Chen, Jodi Kroeger, Biwei Cao, Adam W. Mailloux, Alisha Agrawal, Braydon J. Schaible, Amod Sarnaik, Jeffrey S. Weber, Anders E. Berglund, James J. Mulé, Joseph Markowitz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Phenotyping of immune cell subsets in clinical trials is limited to well-defined phenotypes, due to technological limitations of reporting flow cytometry multi-dimensional phenotyping data. We developed a multi-dimensional phenotyping analysis tool a
Externí odkaz:
https://doaj.org/article/27868eabfece4beba9ed09c42344dbf3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 297 (2021)
Stemness reprogramming remains a largely unaddressed principal cause of lethality in glioblastoma (GBM). It is therefore of utmost importance to identify and target mechanisms that are essential for GBM stemness and self-renewal. Previously, we impli
Externí odkaz:
https://doaj.org/article/8d1323bc48ba4edda6f79849dd5dda34
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8324 (2021)
Glioblastoma (GBM) is a highly lethal cancer that is universally refractory to the standard multimodal therapies of surgical resection, radiation, and chemotherapy treatment. Temozolomide (TMZ) is currently the best chemotherapy agent for GBM, but th
Externí odkaz:
https://doaj.org/article/2988f63042ad4ac5bd42cc49e7d9c742
Autor:
Jamie K. Teer, Yonghong Zhang, Lu Chen, Eric A. Welsh, W. Douglas Cress, Steven A. Eschrich, Anders E. Berglund
Publikováno v:
Human Genomics, Vol 11, Iss 1, Pp 1-13 (2017)
Abstract Background Observations of recurrent somatic mutations in tumors have led to identification and definition of signaling and other pathways that are important for cancer progression and therapeutic targeting. As tumor cells contain both an in
Externí odkaz:
https://doaj.org/article/617587bcde17463eaf2d11a7e78d9a43
Autor:
Sangeetha Prabhakaran, Victoria T. Rizk, Zhenjun Ma, Chia-Ho Cheng, Anders E. Berglund, Dominico Coppola, Farah Khalil, James J. Mulé, Hatem H. Soliman
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-11 (2017)
Abstract Background A unique 12-chemokine gene expression score (CS) accurately predicted the presence of tumor-localized, ectopic lymph node-like structures (TL-ELNs) and improved overall survival (OS) in primary colorectal cancer and metastatic mel
Externí odkaz:
https://doaj.org/article/db8836d13b1640749336fcfa10fd7545
Autor:
Genyuan Zhu, Satoshi Nemoto, Adam W. Mailloux, Patricio Perez-Villarroel, Ryosuke Nakagawa, Rana Falahat, Anders E. Berglund, James J. Mulé
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tertiary lymphoid structures (TLSs) associate with better prognosis in certain cancer types, but their underlying formation and immunological benefit remain to be determined. We established a mouse model of TLSs to study their contribution to antitum
Externí odkaz:
https://doaj.org/article/46cd8b619d2d498ab2902f6713f81d7d