Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Anders Castor"'
Publikováno v:
BMC Medical Ethics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Childhood cancers affect about 350 children every year in Sweden and are life-threatening diseases. During the treatment period, situations arise that can become morally challenging for the child. When knowing children’s values
Externí odkaz:
https://doaj.org/article/eeabb1e714e94726994782d37136da53
Autor:
Qirui Zhang, Ton Falqués‐Costa, Mattias Pilheden, Helena Sturesson, Tina Ovlund, Vendela Rissler, Anders Castor, Hanne V. H. Marquart, Birgitte Lausen, Thoas Fioretos, Axel Hyrenius‐Wittsten, Anna K. Hagström‐Andersson
Publikováno v:
HemaSphere, Vol 8, Iss 9, Pp n/a-n/a (2024)
Abstract Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A‐gene rearrangements (KMT2A‐r). However, how these mutations cooperate with the KMT2A‐r to remodel the epigenetic landscape is unknown. Using a retroviral acute mye
Externí odkaz:
https://doaj.org/article/8ac45f1ff8bd4b6db5372692fc30dd64
Autor:
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleo
Externí odkaz:
https://doaj.org/article/e563771b49d648d5b6ca5d0983fb3490
Autor:
Eleanor L. Woodward, Minjun Yang, Larissa H. Moura-Castro, Hilda van den Bos, Rebeqa Gunnarsson, Linda Olsson-Arvidsson, Diana C. J. Spierings, Anders Castor, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Bertil Johansson, Floris Foijer, Kajsa Paulsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
High hyperdiploid acute lymphoblastic leukaemia (HeH ALL) is driven by nonrandom chromosomal gains, which have been suggested to arise early - even before birth. Here, the authors use single-cell whole genome sequencing and in silico modelling to sho
Externí odkaz:
https://doaj.org/article/64d0d9d155f840b1a5e6a3ed8a02925f
Autor:
Mattias Pilheden, Louise Ahlgren, Axel Hyrenius-Wittsten, Veronica Gonzalez-Pena, Helena Sturesson, Hanne Vibeke Hansen Marquart, Birgitte Lausen, Anders Castor, Cornelis Jan Pronk, Gisela Barbany, Katja Pokrovskaja Tamm, Linda Fogelstrand, Olli Lohi, Ulrika Norén-Nyström, Johanna Asklin, Yilun Chen, Guangchun Song, Michael Walsh, Jing Ma, Jinghui Zhang, Lao H. Saal, Charles Gawad, Anna K. Hagström-Andersson
Publikováno v:
HemaSphere, Vol 6, Iss 10, p e785 (2022)
Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted dupl
Externí odkaz:
https://doaj.org/article/3d8b60cb5ba24eb4960d6445495d3946
Publikováno v:
BMC Medical Ethics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background In childhood cancer care, healthcare professionals must deal with several difficult moral situations in clinical practice. Previous studies show that morally difficult challenges are related to decisions on treatment limitations,
Externí odkaz:
https://doaj.org/article/a78f5cacc5714bf9914e03bd7fb5ae9b
Autor:
Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H. Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T. Odom, Linda Olsson, Naveen Ravi, Eleanor L. Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
High hyperploidy is a common feature in childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors perform proteogenomic and Hi-C analyses of this leukemia and the ETV6/RUNX1 subtype and show that CTCF and cohesin expression are low i
Externí odkaz:
https://doaj.org/article/8fb5db51725140f997f862673ee0cf51
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 8, Pp n/a-n/a (2020)
Abstract Background With the implementation of a research project providing whole genome sequencing (WGS) to all pediatric cancer patients in Denmark (2016–2019), we sought to investigate healthcare professionals' views on WGS as it was actively be
Externí odkaz:
https://doaj.org/article/0168a4552eee48f0a567a92f586668b8
Publikováno v:
BMJ Open, Vol 9, Iss 8 (2019)
Objectives Global incidence and attention to childhood cancer is increasing and treatment abandonment is a major cause of treatment failure in low- and middle-income countries. The purpose of this study was to gain an understanding of factors contrib
Externí odkaz:
https://doaj.org/article/87d56fc40cdc452e9207defa698017d4
Autor:
Andrea Biondi, Gunnar Cario, Paola De Lorenzo, Anders Castor, Valentino Conter, Veronica Leoni, Virginie Gandemer, Rob Pieters, Jan Stary, Gabriele Escherich, Myriam Campbell, Andishe Attarbaschi, Chi-Kong Li, Ajay Vora, Jutta Bradtke, Vaskar Saha, Maria Grazia Valsecchi, Martin Schrappe
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
Externí odkaz:
https://doaj.org/article/57436aa6877740b490524c9b48c4d51b