Framework for sensitization assessment of extractables and leachables in pharmaceuticals

Autor: Patricia Parris, Geraldine Whelan, Anders Burild, Jessica Whritenour, Uma Bruen, Joel Bercu, Courtney Callis, Jessica Graham, Esther Johann, Troy Griffin, Martin Kohan, Elizabeth A. Martin, Melisa Masuda-Herrera, Brad Stanard, Eric Tien, Maureen Cruz, Lee Nagao

Publikováno v: Critical Reviews in Toxicology. 52:125-138

During the toxicological assessment of extractables and leachables in drug products, localized hazards such as irritation or sensitization may be identified. Typically, because of the low concentration at which leachables occur in pharmaceuticals, ir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a6a7a140e0285b747a1ffba19dc2da
https://doi.org/10.1080/10408444.2022.2065966

Quantification of physiological levels of vitamin D3 and 25-hydroxyvitamin D3 in porcine fat and liver in subgram sample sizes

Autor: Morten Poulsen, Anders Burild, Henrik Lauritz Frandsen, Jette Jakobsen

Publikováno v: Journal of Separation Science. 37:2659-2663

Most methods for the quantification of physiological levels of vitamin D3 and 25-hydroxyvitamin D3 are developed for food analysis where the sample size is not usually a critical parameter. In contrast, in life science studies sample sizes are often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de0a053092eb2c8174b50bb8ca673450
https://doi.org/10.1002/jssc.201400548

Vitamin D3 and 25-hydroxyvitamin D3 in pork and their relationship to vitamin D status in pigs

Autor: Charlotte Lauridsen, Nasrin Faqir, Anders Burild, Jette Jakobsen, Helle Mølgaard Sommer

Publikováno v: Journal of Nutritional Science
Burild, A, Lauridsen, C, Faqir, N, Sommer, H M & Jakobsen, J 2016, ' Vitamin D 3 and 25-hydroxyvitamin D 3 in pork and their relationship to vitamin D status in pigs ', Journal of Nutritional Science, vol. 5, e3 . https://doi.org/10.1017/jns.2015.28
Burild, A, Lauridsen, C, Faqir, N, Sommer, H M & Jakobsen, J 2016, ' Vitamin D3 and 25-hydroxyvitamin D3 in pork and their relationship to vitamin D status in pigs ', Journal of Nutritional Science, vol. 5, e3 . https://doi.org/10.1017/jns.2015.28

The content of vitamin D in pork produced in conventional systems depends on the vitamin D concentration in the pig feed. Both vitamin D3 and 25-hydroxyvitamin D3 (25(OH)D3) are essential sources of dietary vitamin D; however, bioavailability assesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20612e6f8f1597ae21bb8a495fbe3d7f
https://pubmed.ncbi.nlm.nih.gov/26793309

Tissue content of vitamin D3 and 25-hydroxy vitamin D3 in minipigs after cutaneous synthesis, supplementation and deprivation of vitamin D3

Autor: Morten Poulsen, Jette Jakobsen, Anders Burild, Henrik Lauritz Frandsen

Publikováno v: Steroids. 98

Information regarding the endogenous storages of vitamin D3 after cutaneous vitamin D synthesis compared to oral vitamin D3 supplementation is sparse. Furthermore it is not known whether vitamin D3 can be stored for later use during periods of shorta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e991f931c7ea9242b4ec89faa4a9c7
https://pubmed.ncbi.nlm.nih.gov/25725256

Simultaneous quantification of vitamin D₃, 25-hydroxyvitamin D₃ and 24,25-dihydroxyvitamin D₃ in human serum by LC-MS/MS

Autor: Anders, Burild, Henrik L, Frandsen, Jette, Jakobsen

Publikováno v: Scandinavian journal of clinical and laboratory investigation. 74(5)

Serum 25-hydroxy-vitamin D is the established biomarker of vitamin D status although serum concentrations of vitamin D and 24,25-dihydroxyvitamin D may also be of interest to understand the in vivo kinetics of serum 25-hydroxyvitamin D.An LC-MS/MS me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59b82afee270ab13f27cb6cbda1cf56e
https://pubmed.ncbi.nlm.nih.gov/24749986