Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Anders Brunmark"'
Autor:
Anders Brunmark, Liming Huang, Kirsten L. Arienti, Kelly J. McClure, J. Guy Breitenbucher, Frank U. Axe, Jon Blevitt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1924-1928
In a recent paper, [Arienti, K. L.; Brunmark, A.; Axe, F. U.; McClure, K. M.; Lee, A.; Blevitt, J.; Neff, D. K.; Huang, L.; Crawford, S.; Chennagiri, R. P.; Karlsson, L.; Brietenbucher, J. G. J. Med. Chem.2005, 48, 1873], we described the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fe9b2e1dadea11395cc5a094cc0c66
https://doi.org/10.1016/j.bmcl.2005.12.096
https://doi.org/10.1016/j.bmcl.2005.12.096
Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles
Autor:
Anders Brunmark, Danielle K. Neff, Shelby Crawford, Lars Karlsson, Kelly J. McClure, Alice Lee, J. Guy Breitenbucher, Chennagiri R. Pandit, Frank U. Axe, Kristen L. Arienti, Jon Blevitt, Liming Huang
Publikováno v:
Journal of Medicinal Chemistry. 48:1873-1885
The discovery of a series of novel, potent, and highly selective inhibitors of the DNA damage control kinase chk2 is disclosed. Here we report the first SAR study around inhibitors of this kinase. High-throughput screening of purified human chk2 led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df8e2ecf621defa959c85adfd13db8
https://doi.org/10.1021/jm0495935
https://doi.org/10.1021/jm0495935
Publikováno v:
The Journal of Immunology. 168:6120-6127
Both a dramatic decline in CD8 responses and a switch to memory T cell predominance occur with aging. The extent to which the loss of responsiveness is the consequence of the accumulation of more differentiated vs intrinsically defective T cells (or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e953b387f01efb99b8fabeda4ff9182
https://doi.org/10.4049/jimmunol.168.12.6120
https://doi.org/10.4049/jimmunol.168.12.6120
Autor:
Ian A. Wilson, Niklas Mattsson, Markus G. Rudolph, Anders Brunmark, Luc Teyton, Jeffrey A. Speir, Per A. Peterson, Michael R. Jackson
Publikováno v:
Immunity. 14(3):231-242
The K bm1 and K bm8 natural mutants of the murine MHC class I molecule H-2K b were originally identified by allograft rejection. They also bind viral peptides VSV8 and SEV9 with high affinity, but their peptide complexes have substantially decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c7815d69aa00d1b5cae19ce4ff7af4
Autor:
Michael R. Jackson, Zeling Cai, Anders Brunmark, Jing-Feng Huang, Hidehiro Kishimoto, Jonathan Sprent, Charles D. Surh, Inkyu Hwang, Per A. Peterson
Publikováno v:
The Journal of Experimental Medicine
At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)–peptide–major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6c2f649e3b2494f0f1f3a1fe043817
http://europepmc.org/articles/PMC2193171
http://europepmc.org/articles/PMC2193171
Autor:
Alain T. Luxembourg, Anders Brunmark, Yan Kong, Michael R. Jackson, Per A. Peterson, Jonathan Sprent, Zeling Cai
Publikováno v:
The Journal of Immunology. 161:5226-5235
In the absence of costimulation, TCR recognition of peptide/MHC complexes is generally considered to be nonimmunogenic. In agreement with this view, naive TCR transgenic CD8+ cells failed to respond to specific peptides presented by MHC class I (Ld)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d6b31775ab1766f540a75e98e94af7b
https://doi.org/10.4049/jimmunol.161.10.5226
https://doi.org/10.4049/jimmunol.161.10.5226
Publikováno v:
Immunity. 9:475-483
We describe antagonist peptides that specifically inhibit cytolytic activity of T cell clones and lines that express the antigen-specific receptor of CD8 + T lymphocyte clone 2C, which recognizes peptides in association with syngeneic (K b ) and allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e569f79b9a4ff7809648e0e9d22730d
https://doi.org/10.1016/s1074-7613(00)80631-7
https://doi.org/10.1016/s1074-7613(00)80631-7
Autor:
Jeffrey Skolnick, A Vitiello, Anders Brunmark, Michael R. Jackson, Mariusz Milik, Per A. Peterson, Dean Sauer, Lunli Yuan, Charles A. Glass
Publikováno v:
Nature Biotechnology. 16:753-756
Computational methods were used to predict the sequences of peptides that bind to the MHC class I molecule, K(b). The rules for predicting binding sequences, which are limited, are based on preferences for certain amino acids in certain positions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa2cd9beab001e5dce3724cf30a142
https://doi.org/10.1038/nbt0898-753
https://doi.org/10.1038/nbt0898-753
Autor:
Alain T. Luxembourg, Persephone Borrow, Per A. Peterson, Michael R. Jackson, Anders Brunmark, Luc Teyton
Publikováno v:
Nature Biotechnology. 16:281-285
Isolating antigen-specific T lymphocytes is hampered by the low frequency of the cells and the low affinity between T-cell receptors (TCR) and antigen. We describe the isolation and purification of antigen-specific CD8+ T lymphocytes from mixed T-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51575106e20f4266570b2a5e089e01f8
https://doi.org/10.1038/nbt0398-281
https://doi.org/10.1038/nbt0398-281
Autor:
Wai-Ping Fung-Leung, Alexander Y. Rudensky, Charles D. Surh, Lars Karlsson, Monika Liljedahl, Phillip Wong, Anders Brunmark, Luc Teyton, Ola Winqvist, Per A. Peterson, Karen Ngo
Publikováno v:
Immunity. 8(2):233-243
HLA-DM catalyzes the release of MHC class II–associated invariant chain–derived peptides (CLIP) from class II molecules. Recent evidence has suggested that HLA-DO is a negative regulator of HLA-DM in B cells, but the physiological function of HLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953a80202c23a00e644559a06b65b87e