Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Anders Björkbom"'
Autor:
Lars Weidolf, Xue-Qing Li, Anders Dahlén, Shalini Andersson, Marie Elebring, David Janzén, Peter Gennemark, Mikko Hölttä, Anders Björkbom
Publikováno v:
Drug Discovery Today. 26:2244-2258
Drug properties of antisense oligonucleotides (ASOs) differ significantly from those of traditional small-molecule therapeutics. In this review, we focus on ASO disposition, mainly as characterized by distribution and biotransformation, of nonconjuga
Autor:
Anders Björkbom, Andreas Hugerth, Katrin Walter, David Janzén, S. F. Nunes, Stanko Skrtic, Bertil Abrahamsson, Christel A. S. Bergström, Werner Weitschies, Julius Krause, Said Harun, Staffan Berg, Malin Antonsson, Natalie Van Zuydam, Nigel Davies, Andreas Granfeldt
Publikováno v:
Journal of Pharmaceutical Sciences. 110:228-238
In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhan
Autor:
Hans M.G. Princen, Linnéa Bergenholm, Jonathan Bright, Maria Hammarberg, Eva Lundborg, Elsbet J. Pieterman, Rahul Agrawal, Glen Hawthorne, Annica Jarke, Anders Cavallin, Eva Hurt-Camejo, Bertil Abrahamsson, Rasmus Jansson-Löfmark, V. Sashi Gopaul, Magnus Johansson, Anders Björkbom, Lena Svensson, Xue-Qing Li
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 161
We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipop
Autor:
Tommy B. Andersson, Carina Leandersson, Kajsa P. Kanebratt, Kristin Samuelsson, Marie Persson, Constanze Hilgendorf, Liisa Vilén, Anna Vildhede, Annika Janefeldt, Anders Björkbom, Lucas Milton
Publikováno v:
Journal of pharmaceutical sciences. 110(1)
3D cultures of primary human hepatocytes (PHH) are emerging as a more in vivo-like culture system than previously available hepatic models. This work describes the characterisation of drug metabolism in 3D PHH spheroids. Spheroids were formed from th
Autor:
Madeleine, Ernst, Simon, Rogers, Ulrik, Lausten-Thomsen, Anders, Björkbom, Susan Svane, Laursen, Julie, Courraud, Anders, Børglum, Merete, Nordentoft, Thomas, Werge, Preben Bo, Mortensen, David M, Hougaard, Arieh S, Cohen
Publikováno v:
Pediatric research. 89(6)
Prematurity is a severe pathophysiological condition, however, little is known about the gestational age-dependent development of the neonatal metabolome.Using an untargeted liquid chromatography-tandem mass spectrometry metabolomics protocol, we mea
Autor:
Victor S. Lelyveld, Piotr Sliz, Elizabeth Ransey, Przemyslaw Biecek, Lorena Pantano, Anders Björkbom, Jack W. Szostak
Publikováno v:
RNA Biology
It remains a formidable challenge to characterize the diverse complexes of RNA binding proteins and their targets. While crosslink and immunoprecipitation (CLIP) methods are powerful techniques that identify RNA targets on a global scale, the resolut
Autor:
Enver Cagri Izgu, Noam Prywes, Anders Björkbom, Chun Pong Tam, Albert C. Fahrenbach, Jack W. Szostak
Publikováno v:
Journal of the American Chemical Society
Origins of life hypotheses often invoke a transitional phase of nonenzymatic template-directed RNA replication prior to the emergence of ribozyme-catalyzed copying of genetic information. Here, using NMR and ITC, we interrogate the binding affinity o
Autor:
Victor S. Lelyveld, Jack W. Szostak, Anders Björkbom, Enver Cagri Izgu, Tony Z. Jia, Weicheng Zhang, Neha P. Kamat
Publikováno v:
Journal of the American Chemical Society
Early protocells are likely to have arisen from the self-assembly of RNA, peptide, and lipid molecules that were generated and concentrated within geologically favorable environments on the early Earth. The reactivity of these components in a prebiot
Autor:
J. Craig Blain, Victor S. Lelyveld, Weicheng Zhang, Chun Pong Tam, Anders Björkbom, Shenglong Zhang, Jack W. Szostak
Publikováno v:
Journal of the American Chemical Society
Mass spectrometry (MS) is a powerful technique for characterizing noncanonical nucleobases and other chemical modifications in small RNAs, yielding rich chemical information that is complementary to high-throughput indirect sequencing. However, mass
Publikováno v:
Journal of the American Chemical Society
High affinity RNA-protein interactions are critical to cellular function, but directly identifying the determinants of binding within these complexes is often difficult. Here, we introduce a stable isotope mass labeling technique to assign specific i