Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anders, Soehoel"'
Publikováno v:
Clinical Pharmacology in Drug Development. 11:910-921
Tralokinumab is the first biologic therapy for moderate-to-severe atopic dermatitis (AD) that specifically neutralizes interleukin-13 activity, a key driver of AD signs and symptoms. Tralokinumab is a human immunoglobulin G4 monoclonal antibody admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7771c3471560152a8af8a094a90cb6e
https://doi.org/10.1002/cpdd.1113
https://doi.org/10.1002/cpdd.1113
Autor:
Thomas Vifian, Tatiana G Stilou, Simon Feldbaek Nielsen, Maja Lambert, Jens Christian Højland Larsen, Tine Skak-Nielsen, Anders Soehoel, Pontus Hegardt, Lene M. Hansen, Nina Østergaard Knudsen, Morten Dahl Sørensen, Mogens Larsen, Cecilia Eskilsson, Steen Laursen, Stefan Eirefelt, Henrik Pettersson, Anna Ollerstam
Publikováno v:
Journal of Medicinal Chemistry. 63:14502-14521
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb38d7abc4b9986a9e38e75c9c4ae01
https://doi.org/10.1021/acs.jmedchem.0c00797
https://doi.org/10.1021/acs.jmedchem.0c00797
Autor:
Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen
Publikováno v:
Journal of medicinal chemistry. 63(23)
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91d778dd5cf2a7a2234d7f9358d53149
https://pubmed.ncbi.nlm.nih.gov/33054196
https://pubmed.ncbi.nlm.nih.gov/33054196