Zobrazeno 1 - 10 of 697 pro vyhledávání: '"Anders, Björklund"'
1
Akademický článek
Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective
Autor: Anders Björklund, Malin Parmar
Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)
The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-establish afferent and efferent connections with the host. In this review article, we give an overview of past and current efforts to restore damaged conn
Externí odkaz: https://doaj.org/article/b700fb73b9364c9284cefcfede0266b8
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2
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System
Autor: Anders Björklund, Fredrik Nilsson, Bengt Mattsson, Deirdre B. Hoban, Malin Parmar
Publikováno v: Journal of Parkinson's Disease. 12:2307-2320
Injections of pre-formed α-synuclein fibrils (PFFs) or overexpression of α-synuclein using AAV vectors are commonly used as models of Parkinson-like synucleinopathy in rats and mice. In the modified method reviewed here, the “SynFib” model, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82102a97c02fb2ea66dd33df6379cb9a
https://doi.org/10.3233/jpd-223452
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3
Akademický článek
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease
Autor: Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B. Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parmar
Publikováno v: Cell Reports, Vol 28, Iss 13, Pp 3462-3473.e5 (2019)
Summary: Cell replacement is currently being explored as a therapeutic approach for neurodegenerative disease. Using stem cells as a source, transplantable progenitors can now be generated under conditions compliant with clinical application in patie
Externí odkaz: https://doaj.org/article/241972c2dfa7453fb809ca4e9f8a415f
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9
In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?
Autor: Anders Björklund, Malin Parmar, Tomas Björklund
Publikováno v: Current Opinion in Genetics & Development
Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or lineage reprogramming. A series of studies have shown that it is possible to reprogram resident
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee731825a0dc04547e283ba06f90433
https://doi.org/10.1016/j.gde.2021.06.002
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10
Akademický článek
Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells
Autor: Lachlan H. Thompson, Anders Björklund
Publikováno v: Neurobiology of Disease, Vol 79, Iss , Pp 28-40 (2015)
Pluripotent stem cells (embryonic stem cells, ESCs, and induced pluripotent stem cells, iPSCs) have the capacity to generate neural progenitors that are intrinsically patterned to undergo differentiation into specific neuronal subtypes and express in
Externí odkaz: https://doaj.org/article/fefdd2c1b93d4e40817264f216033e6b
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