Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Ander Francisco Pereira"'
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Akademický článek
Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study
Autor: Jorge Alberto Valle da Silva, Ander Francisco Pereira, Steven R. LaPlante, Kamil Kuca, Teodorico Castro Ramalho, Tanos Celmar Costa França
Publikováno v: Biomolecules, Vol 10, Iss 2, p 192 (2020)
In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) inhibited by the nerve ag
Externí odkaz: https://doaj.org/article/b75a208e14a8474dbfa684f70c30c5a0
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2
Non-conventional compounds with potential therapeutic effects against Alzheimer’s disease
Autor: Teodorico C. Ramalho, Kamil Kuca, Daniel A. Polisel, Daniel H. S. Leal, Elaine F. F. da Cunha, Ander Francisco Pereira, Alexandre A. de Castro, Eugenie Nepovimova, Melissa S. Caetano, Flávia V. Soares
Publikováno v: Expert Review of Neurotherapeutics. 19:375-395
Alzheimer's disease (AD) is the most common cause of dementia. Clinical progress in this pathogenesis field has drawn the attention of researchers, stimulating the investigation of novel treatment methods. Current therapies that deal with cholinester
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7002d20c72603bfabf3fc5a9778020ea
https://doi.org/10.1080/14737175.2019.1608823
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3
Asymmetric biodegradation of the nerve agents Sarin and VX by human dUTPase: chemometrics, molecular docking and hybrid QM/MM calculations
Autor: Elaine F. F. da Cunha, Daiana T. Mancini, Teodorico C. Ramalho, Alexandre A. de Castro, Melissa S. Caetano, Flávia V. Soares, Daniela Rodrigues Silva, Ander Francisco Pereira, Telles Cardoso Silva
Publikováno v: Journal of Biomolecular Structure and Dynamics. 37:2154-2164
Organophosphorus compounds (OP) nerve agents are among the most toxic chemical substances known. Their toxicity is due to their ability to bind to acetylcholinesterase. Currently, some enzymes, such as phosphotriesterase, human serum paraoxonase 1 an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169faf8010fbd07bf534ebce3343357f
https://doi.org/10.1080/07391102.2018.1478751
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5
Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study
Autor: Kamil Kuca, Teodorico C. Ramalho, Steven R. LaPlante, Tanos C. C. França, Ander Francisco Pereira, Jorge Alberto Valle da Silva
Publikováno v: Biomolecules, Vol 10, Iss 2, p 192 (2020)
Biomolecules
Volume 10
Issue 2
In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) inhibited by the nerve ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a6f243b600b7c1dba17a8973544ae
https://www.mdpi.com/2218-273X/10/2/192
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6
Insights into the Drug Repositioning Applied to the Alzheimer's Disease Treatment and Future Perspectives
Autor: Daniel H. S. Leal, Flávia V. Soares, Elaine F. F. da Cunha, Teodorico C. Ramalho, Kamil Kuca, Ander Francisco Pereira, Alexandre A. de Castro
Publikováno v: Current Alzheimer Research. 15:1161-1178
Introduction: Alzheimer's disease is known to be a chronic disease, with an estimated prevalence of about 10-30%, considering the population over 60 years of age. Most patients with this disorder (> 95%) present the sporadic form, being characterized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e4254277d2474fe0002bde4dabdfe3
https://doi.org/10.2174/1567205015666180813150703
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7
Development of technologies applied to the biodegradation of warfare nerve agents: Theoretical evidence for asymmetric homogeneous catalysis
Autor: Flávia V. Soares, Ander Francisco Pereira, Elaine F. F. da Cunha, Daniel H. S. Leal, Daiana T. Mancini, Alexandre A. de Castro, Teodorico C. Ramalho
Publikováno v: Chemico-biological interactions. 308
Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides, resulting in a huge number of people intoxicated annually, being a serious problem of public health. Efforts worldwide have been done in o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7bf2f843ee47ff25a13046fea67880
https://pubmed.ncbi.nlm.nih.gov/31173750
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8
Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication
Autor: Flávia V. Soares, Daniel H. S. Leal, Teodorico C. Ramalho, Daiana T. Mancini, Elaine F. F. da Cunha, Alexandre A. de Castro, Kamil Kuca, Ander Francisco Pereira, Ondrej Krejcar
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1257
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1257 (2018)
Organophosphorus compounds (OP) are part of a group of compounds that may be hazardous to health. They are called neurotoxic agents because of their action on the nervous system, inhibiting the acetylcholinesterase (AChE) enzyme and resulting in a ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d62e7f47d8136c66df85939a75820b7
https://doi.org/10.3390/ijms19041257
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