Analysis of extracellular matrix network dynamics in cancer using the MatriNet database

Autor: Juho Kontio, Valeria Rolle Soñora, Vilma Pesola, Rijuta Lamba, Annalena Dittmann, Ander Diaz Navarro, Jarkko Koivunen, Taina Pihlajaniemi, Valerio Izzi

Publikováno v: Scopus

The extracellular matrix (ECM) is a three-dimensional network of proteins of diverse nature, whose interactions are essential to provide tissues with the correct mechanical and biochemical cues they need for proper development and homeostasis. Change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a686b769d5dd7a4ae8cba8eaec004
https://doi.org/10.1016/j.matbio.2022.05.006

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

Autor: Xose S. Puente, Ana Muntañola, Ander Diaz-Navarro, José I. Martín-Subero, Blanca Espinet, Roser Vilarrasa-Blasi, Guillem Clot, Cristina López, Marta Kulis, Ferran Nadeu, Rafael Valdés-Mas, Vicente Chapaprieta, Marta Aymerich, Dolors Costa, Elias Campo, David Torrents, Sílvia Beà, Jesús Gutiérrez-Abril, Armando López-Guillermo, David Martín-García, Pedro Jares, Ralf Küppers, Eva Giné, Inmaculada Ribera-Cortada, Montserrat Puiggròs, Giancarlo Castellano, Dolors Colomer, Romina Royo, Martí Duran-Ferrer, Alba Navarro, Reiner Siebert

Publikováno v: Blood. 136:1419-1432

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non-nodal MCL (nnMCL), that differ in their clinicobiological behavior. To identify the gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc500617eb285de60b0c605c689d1b3
https://doi.org/10.1182/blood.2020005289

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

Autor: Anna Petit, Eva González-Suárez, Gerburg M. Wulf, Bing Zhang, Carlos Caldas, Michael T. Lewis, Joaquín Arribas, Xose S. Puente, Eva M. Trinidad, Luis Palomero, Judith Balmaña, María Teresa Soler-Monso, Marta Palafox, Lacey E. Dobrolecki, Alejandra Bruna, Suhas Vasaikar, Aleix Prat, Violeta Serra, Ander Diaz-Navarro, Jorge Gomez-Miragaya, Laia Paré, Sergi Beltran, Alejandro Collado-Sole, Purificación Muñoz, Raul Tonda, Miguel Angel Pujana, Chen Huang, Cristina Cruz

Publikováno v: Cancer Research. 79:4258-4270

Taxanes are the mainstay of treatment in triple-negative breast cancer (TNBC), with de novo and acquired resistance limiting patient's survival. To investigate the genetic basis of docetaxel resistance in TNBC, exome sequencing was performed on match

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cd2d6c782830ed18ab9d3643cc14fde
https://doi.org/10.1158/0008-5472.can-18-3835

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma

Autor: Anne Jouvet, Ana Gutiérrez-Fernández, Namal Abeysundara, Olivier Ayrault, Vijay Ramaswamy, Charles G. Eberhart, Jennifer A. Chan, Johan M. Kros, Xiaochong Wu, Sachin Kumar, Seung-Ki Kim, Maria C. Vladoiu, Noriyuki Kijima, Xose S. Puente, Ian F. Pollack, Robert J. Wechsler-Reya, Boleslaw Lach, Almos Klekner, Ander Diaz-Navarro, Claudia C. Faria, Lincoln Stein, Nicole Gauer, Enrique López-Aguilar, Nada Jabado, Amulya A. Nageswara Rao, Livia Garzia, David Malkin, Stefan M. Pfister, Jiannis Ragoussis, Maura Massimino, James M. Olson, Caterina Giannini, Hamza Farooq, Pim J. French, Florence M.G. Cavalli, Anna Goldenberg, John A. Calarco, Joshua B. Rubin, Maria Luisa Garrè, Betty Luu, László Bognár, Weifan Dong, Shimin Shuai, Antoine Forget, Jun Wang, Ichiyo Shibahara, Pasqualino De Antonellis, William A. Weiss, Marco A. Marra, Lola B. Chambless, Patryk Skowron, Wiesława Grajkowska, Jiao Zhang, Ali Momin, Erwin G. Van Meir, Michelle Fèvre-Montange, Rajeev Vibhakar, Ho Keung Ng, David Przelicki, Hiromichi Suzuki, Kyle Juraschka, Craig Daniels, A. Sorana Morrissy, Toshihiro Kumabe, Xi Huang, Wai Sang Poon, Swneke D. Bailey, Michael D. Taylor

Publikováno v: Nature, 574(7780), 707-+. Nature Publishing Group
Nature
Nature, Nature Publishing Group, 2019
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© The Author(s), under exclusive licence to Springer Nature Limited 2019
In cancer, recurrent somatic single-nucleotide variants-which are rare in most paediatric cancers-are confined largely to protein-coding genes1-3. Here we report highly re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf69b6fedf20eee2d65c01dc77b0345b
https://pure.eur.nl/en/publications/87b8ce9e-154a-4fc3-baab-ad9bad99de72

Tumor xenograft modeling identifies TCF4/ITF2 loss associated with breast cancer chemoresistance

Autor: Alberto Villanueva, Miguel Angel Pujana, Conxi Lázaro, María Martínez-Iniesta, August Vidal, Gardenia Vargas-Parra, Idoia Morilla, Luis Palomero, Agostina Stradella, Anna Petit, Jordi Serra-Musach, Diana A. Puente, Eva Tornero, Teresa Soler, Gorka Ruiz de Garibay, Carmen Herranz, Francesca Mateo, Xose S. Puente, Lourdes Farre, Rafael Valdés-Mas, Ander Diaz-Navarro, Emmet McCormack

Publikováno v: Disease Models & Mechanisms.

Understanding the mechanisms of cancer therapeutic resistance is fundamental to improving cancer care. There is clear benefit from chemotherapy in different breast cancer settings; however, knowledge of the mutations and genes that mediate resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0fe24b9395d86b85c0ea5b88e5df5e9
https://doi.org/10.1242/dmm.032292