Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Andelko Hrzenjak"'
Autor:
Theresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak, Thomas Eichmann, Harald C. Köfeler, Katharina Leithner
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Serine and glycine give rise to important building blocks in proliferating cells. Both amino acids are either synthesized de novo or taken up from the extracellular space. In lung cancer, serine synthesis gene expression is variable, yet, ex
Externí odkaz:
https://doaj.org/article/cf80bd30f2314fe2ad36b8e36054d520
Autor:
Christine Rossmann, Cornelia Ranz, Gerd Kager, Gerhard Ledinski, Martin Koestenberger, Willibald Wonisch, Thomas Wagner, Sebastian P. Schwaminger, Bruno Di Geronimo, Andelko Hrzenjak, Seth Hallstöm, Gilbert Reibnegger, Gerhard Cvirn, Margret Paar
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2111 (2023)
Metformin is the most commonly prescribed glucose-lowering drug for the treatment of type 2 diabetes. The aim of this study was to investigate whether metformin is capable of impeding the oxidation of LDL, a crucial step in the development of endothe
Externí odkaz:
https://doaj.org/article/9bbf4f263d38442cb03d53efcf102673
Autor:
Elisabeth Smolle, Petra Leko, Elvira Stacher‐Priehse, Luka Brcic, Amin El‐Heliebi, Lilli Hofmann, Franz Quehenberger, Andelko Hrzenjak, Helmut H. Popper, Horst Olschewski, Katharina Leithner
Publikováno v:
Molecular Oncology, Vol 14, Iss 11, Pp 2853-2867 (2020)
Inhibition of glycolysis has been considered as a therapeutic approach in aggressive cancers including lung cancer. Abbreviated gluconeogenesis, mediated by phosphoenolpyruvate carboxykinase (PEPCK), was recently discovered to partially circumvent th
Externí odkaz:
https://doaj.org/article/a2f2a16a21f04888bfde536c4d65ec87
Autor:
Margret Paar, Faisal Aziz, Caren Sourij, Norbert J. Tripolt, Harald Kojzar, Alexander Müller, Peter Pferschy, Anna Obermayer, Tamara Banfic, Bruno Di Geronimo Quintero, Nandu Goswami, Axel Schlagenhauf, Martin Köstenberger, Thomas Bärnthaler, Thomas Wagner, Andelko Hrzenjak, Willibald Wonisch, Gilbert Reibnegger, Reinhard B. Raggam, Harald Sourij, Gerhard Cvirn
Publikováno v:
Viruses, Vol 15, Iss 1, p 10 (2022)
People with diabetes have an increased risk of experiencing adverse COVID-19 outcomes. COVID-19 vaccination is, therefore, highly recommended. However, people with diabetes have an inherently elevated risk of thrombotic events and the impact of the v
Externí odkaz:
https://doaj.org/article/9dd2b37abd8847b7860bf746042f915f
Autor:
Mateja Mikulčić, Nassim Ghaffari Tabrizi-Wizsy, Eva M. Bernhart, Martin Asslaber, Christopher Trummer, Werner Windischhofer, Wolfgang Sattler, Ernst Malle, Andelko Hrzenjak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11760 (2021)
Osteosarcoma (OS) is the most common type of bone tumor, and has limited therapy options. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has striking anti-tumor effects in various tumors. Here, we investigated molecular mechanisms that mediate anti-tum
Externí odkaz:
https://doaj.org/article/60d805b815b9430988f1f91da671a2fa
Autor:
Irene Schilcher, Julia T. Stadler, Margarete Lechleitner, Andelko Hrzenjak, Andrea Berghold, Gudrun Pregartner, Marie Lhomme, Michael Holzer, Melanie Korbelius, Florian Reichmann, Anna Springer, Christian Wadsack, Tobias Madl, Dagmar Kratky, Anatol Kontush, Gunther Marsche, Saša Frank
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 719 (2021)
Endothelial lipase (EL) is a strong modulator of the high-density lipoprotein (HDL) structure, composition, and function. Here, we examined the impact of EL on HDL paraoxonase 1 (PON1) content and arylesterase (AE) activity in vitro and in vivo. The
Externí odkaz:
https://doaj.org/article/0722a904bd9046ae952c230986b4fed5
Autor:
Katharina Leithner, Birgit Hirschmugl, Yingji Li, Bi Tang, Rita Papp, Chandran Nagaraj, Elvira Stacher, Philipp Stiegler, Jörg Lindenmann, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157453 (2016)
Lung cancer is the leading cause of cancer deaths worldwide; survival times are poor despite therapy. The role of the two-pore domain K+ (K2P) channel TASK-1 (KCNK3) in lung cancer is at present unknown. We found that TASK-1 is expressed in non-small
Externí odkaz:
https://doaj.org/article/f29e5ea005f748e4b4e24e4b9bbafaa7
Autor:
Monika Riederer, Pauli J. Ojala, Andelko Hrzenjak, Wolfgang F. Graier, Roland Malli, Michaela Tritscher, Martin Hermansson, Bernhard Watzer, Horst Schweer, Gernot Desoye, Akos Heinemann, Sasa Frank
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 10, Pp 2957-2966 (2010)
Previously we identified palmitoyl-lysophosphatidylcholine (16:0 LPC), linoleoyl-LPC (18:2 LPC), arachidonoyl-LPC (20:4 LPC), and oleoyl-LPC (18:1 LPC) as the most prominent LPC species generated by the action of endothelial lipase (EL) on high-densi
Externí odkaz:
https://doaj.org/article/11ca0906b9e5414eac90a5203a0313e9
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 5, Pp 977-987 (2005)
Mature endothelial lipase (EL) is a 68 kDa glycoprotein. In HepG2 cells infected with adenovirus encoding human EL, the mature EL was detectable in the cell lysates and heparin-releasable fractions. In contrast, cell media of these cells contained tw
Externí odkaz:
https://doaj.org/article/06300846031948dd8437a842b9051006
Autor:
Elke M. Wagner, Dagmar Kratky, Guenter Haemmerle, Andelko Hrzenjak, Gert M. Kostner, Ernst Steyrer, Rudolf Zechner
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 2, Pp 356-365 (2004)
Lipoprotein lipase (LPL) is the only known enzyme in the capillary endothelium of peripheral tissues that hydrolizes plasma triglycerides and provides fatty acids (FAs) for their subsequent tissue uptake. Previously, we demonstrated that mice that ex
Externí odkaz:
https://doaj.org/article/a54297c35c8c42339798866c061998c8