Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andela Saric"'
Autor:
Paolo Arosio, Sara Linse, Gabriella T. Heller, Andela Saric, Michele Vendruscolo, Christopher M. Dobson, Tuomas P. J. Knowles, Thomas C. T. Michaels, Samo Curk, Georg Meisl
Publikováno v:
Proc Natl Acad Sci U S A
Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possi
Autor:
Thomas C. T. Michaels, Georg Meisl, Andela Saric, Michele Vendruscolo, Katja Bernfur, Samuel I. A. Cohen, Tuomas P. J. Knowles, Christopher M. Dobson, Sara Linse, Samo Curk, Paolo Arosio, Alexander J. Dear
Publikováno v:
Nature Chemistry. 12:445-451
Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By develop
SummaryThe T cell receptor (TCR) pathway receives, processes, and amplifies the signal from pathogenic antigens to the activation of T cells. Although major components in this pathway have been identified, the knowledge on how individual components c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160efddfa8537eb073e60af10ae1cc40
https://doi.org/10.1101/2020.06.30.179630
https://doi.org/10.1101/2020.06.30.179630
One of the most robust examples of self-assembly in living organisms is the formation of collagen architectures. Collagen type I molecules are a crucial component of the extracellular-matrix where they self-assemble into fibrils of well defined strip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d5f558dfa6c144410e60fc4ecc3a30
https://doi.org/10.1101/2020.06.08.140061
https://doi.org/10.1101/2020.06.08.140061
Autor:
Christopher M. Dobson, Paolo Arosio, Sara Linse, Georg Meisl, Michele Vendruscolo, Katja Bernfur, Andela Saric, Thomas C. T. Michaels, Samo Curk, Alexander J. Dear, Samuel I. A. Cohen, Tuomas P. J. Knowles
Oligomeric aggregates populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1737f7f9eceed0d3b7502ccebe355762
ESCRT-III is an evolutionarily conserved membrane remodeling machinery that, with the Vps4 ATPase, forms filaments able to cut biological membranes from the cytosolic side. This activity of ESCRT-III is essential for the final stage of cell division
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5b665402987835d39ef6b4707cb18e
https://doi.org/10.1101/559898
https://doi.org/10.1101/559898
Autor:
Xiuyun Jiang, Lena Harker-Kirschneck, Christian Vanhille-Campos, Anna-Katharina Pfitzner, Elene Lominadze, Aurélien Roux, Buzz Baum, Anđela Šarić
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010586 (2022)
ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III filaments undergo a series of dramatic composition and geometry changes in the presence o
Externí odkaz:
https://doaj.org/article/922a294992104e3dae30951e44653f6d
Autor:
Tanja Weiffert, Georg Meisl, Samo Curk, Risto Cukalevski, Anđela Šarić, Tuomas P. J. Knowles, Sara Linse
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Amyloid formation is linked to devastating neurodegenerative diseases, motivating detailed studies of the mechanisms of amyloid formation. For Aβ, the peptide associated with Alzheimer’s disease, the mechanism and rate of aggregation have been est
Externí odkaz:
https://doaj.org/article/d37c9ffbb60b4063b3536fe69e8183fc
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-8 (2019)
Abstract Background ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, a
Externí odkaz:
https://doaj.org/article/822386bd573a4b178f0bb97273b13047
Publikováno v:
ACS Central Science, Vol 3, Iss 12, Pp 1246-1253 (2017)
Externí odkaz:
https://doaj.org/article/13eb23962c6043b1b48b043b97e9c234