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Akademický článek

Endogenous reactivation cases identified by whole genome sequencing of Mycobacterium tuberculosis: Exploration of possible causes in Latvian tuberculosis patients

Autor: Anda Viksna, Darja Sadovska, Vija Riekstina, Anda Nodieva, Ilva Pole, Renate Ranka, Iveta Ozere

Publikováno v: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 37, Iss , Pp 100493- (2024)

Background: The recurrence of tuberculosis (TB) continues to place a significant burden on patients and TB programs worldwide. Repeated TB episodes can develop either due to endogenous reactivation of previously treated TB or exogenous reinfection wi

Externí odkaz: https://doaj.org/article/25472fa876b646a382bb7341729b2eb3

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Akademický článek

Effect of NAT2, GSTM1 and CYP2E1 genetic polymorphisms on plasma concentration of isoniazid and its metabolites in patients with tuberculosis, and the assessment of exposure-response relationships

Autor: Viktorija Ulanova, Agnija Kivrane, Anda Viksna, Leonora Pahirko, Lauma Freimane, Darja Sadovska, Iveta Ozere, Andra Cirule, Eduards Sevostjanovs, Solveiga Grinberga, Dace Bandere, Renate Ranka

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Objectives: Isoniazid is a key drug in the chemotherapy of tuberculosis (TB), however, interindividual variability in pharmacokinetic parameters and drug plasma levels may affect drug responses including drug induced hepatotoxicity. The current study

Externí odkaz: https://doaj.org/article/c4c2861429c14d29a0cb8b08315e9f4c

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Akademický článek

Exploring Variability in Rifampicin Plasma Exposure and Development of Anti-Tuberculosis Drug-Induced Liver Injury among Patients with Pulmonary Tuberculosis from the Pharmacogenetic Perspective

Autor: Agnija Kivrane, Viktorija Ulanova, Solveiga Grinberga, Eduards Sevostjanovs, Anda Viksna, Iveta Ozere, Ineta Bogdanova, Maksims Zolovs, Renate Ranka

Publikováno v: Pharmaceutics, Vol 16, Iss 3, p 388 (2024)

Genetic polymorphisms can exert a considerable impact on drug pharmacokinetics (PK) and the development of adverse drug reactions (ADR). However, the effect of genetic polymorphisms on the anti-tuberculosis (anti-TB) drug, and particularly rifampicin

Externí odkaz: https://doaj.org/article/2e9f5fa4aeb749c399c85653c3f349ee

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Next-Generation Sequencing and Bioinformatics-Based Protocol for the Full-Length CYP2E1 Gene Polymorphism Analysis

Autor: Viktorija Igumnova, Agnija Kivrane, Anda Viksna, Inga Norvaisa, Renate Ranka

Publikováno v: Pharmacogenomics and Personalized Medicine. 15:959-965

Viktorija Igumnova,1,2 Agnija Kivrane,1,2 Anda Viksna,3,4 Inga Norvaisa,4 Renate Ranka1,2 1Molecular Microbiology Group, Latvian Biomedical Research and Study Centre, Riga, Latvia; 2Department of Pharmaceutical Chemistry, Riga Stradins University, Ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3010318340e1832bfaf014fdb360d1
https://doi.org/10.2147/pgpm.s371709

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Implementation of a next-generation sequencing-based targeted approach for full-length CYP3A4 gene sequencing

Autor: Ilva Pole, Anda Viksna, Viktorija Igumnova, Agnija Kivrane, Janis Kimsis, Lauma Freimane, Renate Ranka, Darja Sadovska

Publikováno v: Pharmacogenomics. 22:519-527

Aim: To evaluate the application of next-generation sequencing-based targeted protocol for full-length CYP3A4 gene sequencing analysis. Materials & methods: The developed sequencing protocol was applied to analyze human DNA samples (n = 7) obtained f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd661c8329c7869937cb8081650674fd
https://doi.org/10.2217/pgs-2020-0128

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