Zobrazeno 1 - 10
of 247
pro vyhledávání: '"And Artur, Schmidtchen"'
Autor:
Erik Hartman, Fredrik Forsberg, Sven Kjellström, Jitka Petrlova, Congyu Luo, Aaron Scott, Manoj Puthia, Johan Malmström, Artur Schmidtchen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Recent advances in mass spectrometry-based peptidomics have catalyzed the identification and quantification of thousands of endogenous peptides across diverse biological systems. However, the vast peptidomic landscape generated by proteolyti
Externí odkaz:
https://doaj.org/article/c9ec928157a341f9943323c6e2aafbe4
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35703- (2024)
Glycosaminoglycans (GAGs) such as heparin and heparan sulfate (HS) play crucial roles in inflammation and wound healing, serving as regulators of growth factors and pro-inflammatory mediators. In this study, we investigated the influence of heparin/H
Externí odkaz:
https://doaj.org/article/7918c8e23f214f4385e0043494db0a02
Autor:
Ganna Petruk, Manoj Puthia, Firdaus Samsudin, Jitka Petrlova, Franziska Olm, Margareta Mittendorfer, Snejana Hyllén, Dag Edström, Ann-Charlotte Strömdahl, Carl Diehl, Simon Ekström, Björn Walse, Sven Kjellström, Peter J. Bond, Sandra Lindstedt, Artur Schmidtchen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection. Thrombin-derived C-terminal peptides (TCPs) are endogenous anti-infective immunomodulators inte
Externí odkaz:
https://doaj.org/article/48831e2d95ee464f9b8c6ceb3f301034
Autor:
Jitka Petrlova, Erik Hartman, Ganna Petruk, Jeremy Chun Hwee Lim, Sunil Shankar Adav, Sven Kjellström, Manoj Puthia, Artur Schmidtchen
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107951- (2023)
Summary: Bacterial lipopolysaccharide (LPS) induces rapid protein aggregation in human wound fluid. We aimed to characterize these LPS-induced aggregates and their functional implications using a combination of mass spectrometry analyses, biochemical
Externí odkaz:
https://doaj.org/article/02dcad32e1ee44f1bdf6cafc2d37d0a9
Autor:
Emma Belfrage, Camilla L. Jinnestål, Andreas Jönsen, Anders Bengtsson, Anna Åkesson, Artur Schmidtchen, Andreas Sonesson
Publikováno v:
Acta Dermato-Venereologica, Vol 103 (2023)
Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lect
Externí odkaz:
https://doaj.org/article/ace2d8a318394c64aec583360a855e68
Autor:
Ganna Petruk, Manoj Puthia, Firdaus Samsudin, Jitka Petrlova, Franziska Olm, Margareta Mittendorfer, Snejana Hyllén, Dag Edström, Ann-Charlotte Strömdahl, Carl Diehl, Simon Ekström, Björn Walse, Sven Kjellström, Peter J. Bond, Sandra Lindstedt, Artur Schmidtchen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/8177fdbc95cf40fb942a53dbd4a15e59
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Introduction TCP-25 gel is intended for use in treatment of wound infection and inflammation. Current local therapies for wounds have limited efficacy to prevent infections and there are no wound treatments available today that target the excessive i
Externí odkaz:
https://doaj.org/article/02c452ce4bdb407cbbf0fda4c6badc19
Autor:
Finja C. Hansen, Aftab Nadeem, Kathryn L. Browning, Mario Campana, Artur Schmidtchen, Mariena J.A. van der Plas
Publikováno v:
Journal of Innate Immunity, Pp 1-15 (2021)
Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli. Previously, we reported that thrombin-derived C-terminal peptides (TCPs) are internalized in mono
Externí odkaz:
https://doaj.org/article/92a1ffab6c0b4c2ca802173005e967bf
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b43ad5314c584473881e6df630addd7e
Autor:
Artur Schmidtchen, Manoj Puthia
Publikováno v:
Bio-Protocol, Vol 12, Iss 2 (2022)
Basic and translational research needs rapid methods to test antimicrobial formulations. Bioluminescent bacteria and advanced imaging systems capable of acquiring bioluminescence enable us to quickly and longitudinally evaluate the efficacy of antimi
Externí odkaz:
https://doaj.org/article/e35ecba0d4a943caa81504998ea5f58c