Zobrazeno 1 - 10
of 57
pro vyhledávání: '"And Abdelaziz Amrani"'
Autor:
Cassidy Tomlinson, Ashwini Rajasekaran, Karine Brochu-Gaudreau, Claire Dubois, A James Farmilo, Pavel Gris, Ariane Khatiz, Amanda Matthews, Marjo Piltonen, Abdelaziz Amrani, Denis Gris
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0308297 (2024)
In recent years, due to the COVID-19 pandemic, there was a surge of research on mRNA therapeutics. The applications are broad and include vaccination, cancer therapy, protein replacement, and immune modulation. mRNA therapeutics have advantages over
Externí odkaz:
https://doaj.org/article/a31b06062fe24c3497f86fcfdb3bb7e8
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Mouse behavior is a primary outcome in evaluations of therapeutic efficacy. Exhaustive, continuous, multiparametric behavioral phenotyping is a valuable tool for understanding the pathophysiological status of mouse brain diseases. Automated home cage
Externí odkaz:
https://doaj.org/article/e608316189d840fb982b044e8331f4a1
Autor:
Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis Gendron, Carles Vilariño-Güell, A Dessa Sadovnick, Jenny P Ting, Peter A Calabresi, Abdelaziz Amrani, Denis Gris
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000451 (2019)
Nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) is a mitochondria-located innate immune sensor that inhibits major pro-inflammatory pathways such as type I interferon and nuclear factor-κB signaling. We generated a novel, spontaneous,
Externí odkaz:
https://doaj.org/article/58ac34a8bf8e4f90ae99175810c13f3c
Autor:
Marjan Gharagozloo, Katsiaryna V. Gris, Tara Mahvelati, Abdelaziz Amrani, John R. Lukens, Denis Gris
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) associated with inappropriate activation of lymphocytes, hyperinflammatory responses, demyelination, and neuronal damage. In the past decade, a number of biological
Externí odkaz:
https://doaj.org/article/853f23d3f69d46bb842b5fe5c82504dd
Publikováno v:
Cells, Vol 8, Iss 5, p 400 (2019)
Uptake of glutamate from the extracellular space and glutamate release to neurons are two major processes conducted by astrocytes in the central nervous system (CNS) that protect against glutamate excitotoxicity and strengthen neuronal firing, respec
Externí odkaz:
https://doaj.org/article/5e71562c83bb4d299676ed1c8b0a518e
Autor:
Chantal Guindi, Farhan Ullah Khan, Alexandre Cloutier, Puregmaa Khongorzul, Ahmed Aziz Raki, Simon Gaudreau, Patrick P. McDonald, Denis Gris, Abdelaziz Amrani
Publikováno v:
Translational research : the journal of laboratory and clinical medicine.
Dendritic cells (DCs) are key regulators of the adaptive immune response. Tolerogenic dendritic cells play a crucial role in inducing and maintaining immune tolerance in autoimmune diseases such as type 1 diabetes in humans as well as in the NOD mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a80c693740f0df7edf80500bd5c930a
https://pubmed.ncbi.nlm.nih.gov/36400308
https://pubmed.ncbi.nlm.nih.gov/36400308
Autor:
Chantal Guindi, Alexandre Cloutier, Simon Gaudreau, Echarki Zerif, Patrick P. McDonald, Olga Tatsiy, Claude Asselin, Gilles Dupuis, Denis Gris, Abdelaziz Amrani
Publikováno v:
Cells, Vol 7, Iss 12, p 256 (2018)
Dendritic cells (DCs) play a major role in innate and adaptive immunity and self-immune tolerance. Immunogenic versus tolerogenic DC functions are dictated by their levels of costimulatory molecules and their cytokine expression profile. The transcri
Externí odkaz:
https://doaj.org/article/046d6f29846543559102859decdbd8b1
Autor:
Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Tara M. Mahvelati, Abdelaziz Amrani, Denis Gris
Publikováno v:
Cells, Vol 7, Iss 9, p 119 (2018)
Although the etiology of multiple sclerosis (MS) remains enigmatic, the role of T cells is unquestionably central in this pathology. Immune cells respond to pathogens and danger signals via pattern-recognition receptors (PRR). Several reports implica
Externí odkaz:
https://doaj.org/article/3cc8d125fb2042aca49897e5cea8ef3c
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience
Mouse behavior is a primary outcome in evaluations of therapeutic efficacy. Exhaustive, continuous, multiparametric behavioral phenotyping is a valuable tool for understanding the pathophysiological status of mouse brain diseases. Automated home cage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847d9e1cac8f34bb5a53a8878be7a874
https://www.frontiersin.org/articles/10.3389/fnins.2021.700253/full
https://www.frontiersin.org/articles/10.3389/fnins.2021.700253/full