Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens

Autor: Valentin Quiniou, Pierre Barennes, Vanessa Mhanna, Paul Stys, Helene Vantomme, Zhicheng Zhou, Federica Martina, Nicolas Coatnoan, Michele Barbie, Hang-Phuong Pham, Béatrice Clémenceau, Henri Vie, Mikhail Shugay, Adrien Six, Barbara Brandao, Roberto Mallone, Encarnita Mariotti-Ferrandiz, David Klatzmann

Publikováno v: eLife, Vol 12 (2023)

T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >1019 sequences. They are selected during thymopoiesis, which releases a repertoire of about 108 unique TCRs per individual. How evolution shaped a process

Externí odkaz: https://doaj.org/article/c330db7a9f61475c8f6b69524299a6bc

GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

Autor: Trudy Straetemans, Guido J. J. Kierkels, Ruud Doorn, Koen Jansen, Sabine Heijhuurs, Joao M. dos Santos, Anna D. D. van Muyden, Henri Vie, Béatrice Clemenceau, Reinier Raymakers, Moniek de Witte, Zsolt Sebestyén, Jürgen Kuball

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-recep

Externí odkaz: https://doaj.org/article/93a04137f7c647068f287b3c812a65cb

Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells

Autor: Florence, Deauvieau, Vincent, Ollion, Anne-Claire, Doffin, Carole, Achard, Jean-François, Fonteneau, Estelle, Verronese, Isabelle, Durand, Raffaella, Ghittoni, Jacqueline, Marvel, Colette, Dezutter-Dambuyant, Thierry, Walzer, Henri, Vie, Ivan, Perrot, Nadège, Goutagny, Christophe, Caux, Jenny, Valladeau-Guilemond

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2015, 136 (5), pp.1085-1094. ⟨10.1002/ijc.29087⟩
International Journal of Cancer, 2015, 136 (5), pp.1085-1094. ⟨10.1002/ijc.29087⟩

International audience; Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce4acf10972f3fc1afaa7001e4c6fc25
https://www.hal.inserm.fr/inserm-02913986/file/ijc.29087.pdf

Decline, with age, in the proportion of mouse T cells that express IL-2 receptors after mitogen stimulation

Autor: Henri Vie, Richard A. Miller

Publikováno v: Mechanisms of ageing and development. 33(3)

Receptors for IL-2 can be demonstrated on the majority of mouse splenic T cells within 48 h after stimulation with Concanavalin A. We show here that aging leads to a decline in the frequency of cells able to generate detectable levels of IL-2 recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ecb2dc3c9c53717330e3fd09ee8d2f
https://pubmed.ncbi.nlm.nih.gov/3086636