Fowlpoxvirus recombinants coding for the CIITA gene increase the expression of endogenous MHC-II and Fowlpox Gag/Pro and Env SIV transgenes.

Autor: Massimiliano Bissa, Greta Forlani, Carlo Zanotto, Giovanna Tosi, Carlo De Giuli Morghen, Roberto S Accolla, Antonia Radaelli

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190869 (2018)

A complete eradication of an HIV infection has never been achieved by vaccination and the search for new immunogens that can induce long-lasting protective responses is ongoing. Avipoxvirus recombinants are host-restricted for replication to avian sp

Externí odkaz: https://doaj.org/article/8fa60407d0ac4c91b2bda95cded0347b

Tripartite Motif-Containing Protein 22 Interacts with Class II Transactivator and Orchestrates Its Recruitment in Nuclear Bodies Containing TRIM19/PML and Cyclin T1

Autor: Greta Forlani, Giovanna Tosi, Filippo Turrini, Guido Poli, Elisa Vicenzi, Roberto S. Accolla

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Among interferon (IFN) inducible antiviral factors both tripartite motif-containing protein 22 (TRIM22) and class II transactivator (CIITA) share the capacity of repressing human immunodeficiency virus type 1 (HIV-1) proviral transcription. TRIM22 is

Externí odkaz: https://doaj.org/article/6da3e3c25ea04d8f9c10bb5d5597f75f

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells

Autor: Giovanna Tosi, Greta Forlani, Tiziana Alberio, Roberto S. Accolla, Marta Lualdi, Mauro Fasano

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)

Background Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and degranulation) in neutrophil ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc35b4a848a563763b095c5b353e43f
https://doi.org/10.1186/s12967-018-1446-2

Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

Autor: Olivier Gout, Roberto S. Accolla, Marco Baratella, Giovanna Tosi, Greta Forlani, Alessandra Tedeschi, Antoine Gessain, Goutham U. Raval

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (1), pp.e0005285. ⟨10.1371/journal.pntd.0005285⟩
PLoS Neglected Tropical Diseases, 2017, 11 (1), pp.e0005285. ⟨10.1371/journal.pntd.0005285⟩
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005285 (2017)

HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Two important HTLV-1-encoded proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d99f32ff8cc16b77f2f412d143a10d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01570215

CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4

Autor: Farah, Bou Nasser Eddine, Greta, Forlani, Letizia, Lombardo, Alessandra, Tedeschi, Giovanna, Tosi, Roberto S, Accolla

Publikováno v: Oncoimmunology. 6(1)

Our previous studies showed that non-immunogenic H-2d tumor cells of distinct epithelial histotypes can become highly immunogenic, induce a protective CD4+ T cell response and vaccinate the animals against parental MHC-II-negative cells if they are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd997a723073d4c4bdef9530a3d709d2
https://pubmed.ncbi.nlm.nih.gov/28197387