Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ancy D. Nalli"'
Autor:
Sunila Mahavadi, Ancy D Nalli, Hongxia Wang, Derek M Kendig, Molly S Crowe, Vijay Lyall, John R Grider, Karnam S Murthy
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209359 (2018)
In gastrointestinal smooth muscle, acetylcholine induced muscle contraction is biphasic, initial peak followed by sustained contraction. Contraction is regulated by phosphorylation of 20 kDa myosin light chain (MLC) at Ser19, interaction of actin and
Externí odkaz:
https://doaj.org/article/a065e35dc5334bd181409ec4303e296e
Autor:
Vanitha eBala, Senthilkumar eRajagopal, Divya P Kumar, Ancy D Nalli, Sunila eMahavadi, Arun J Sanyal, John R Grider, Karnam eMurthy
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Activation of plasma membrane TGR5 receptors in enteroendocrine cells by bile acids is known to regulate gastrointestinal secretion and motility and glucose homeostasis. The endocrine functions of the gut are modulated by microenvironment of the dist
Externí odkaz:
https://doaj.org/article/d95f3450b0bf48589cfca7e457e5a6a7
Publikováno v:
Cancer Research. 80:2401-2401
Ras oncogenes, including H-Ras, K-Ras and N-Ras, are widely implicated in tumorigenesis. Oncogenic K-Ras mutations are found in about 30% of human tumors rendering constitutive activation of Ras-dependent pathways to promote cell proliferation, survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4834fda822b8ffd3b061b55ee848099e
https://doi.org/10.1158/1538-7445.am2020-2401
https://doi.org/10.1158/1538-7445.am2020-2401
Autor:
John R. Grider, Hongxia Wang, Sunila Mahavadi, Molly S. Crowe, Derek M. Kendig, Ancy D. Nalli, Karnam S. Murthy, Vijay Lyall
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0209359 (2018)
PLoS ONE, Vol 13, Iss 12, p e0209359 (2018)
In gastrointestinal smooth muscle, acetylcholine induced muscle contraction is biphasic, initial peak followed by sustained contraction. Contraction is regulated by phosphorylation of 20 kDa myosin light chain (MLC) at Ser19, interaction of actin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089a1cd50a155f64c44ba0834bbb4af0
https://pubmed.ncbi.nlm.nih.gov/31697794
https://pubmed.ncbi.nlm.nih.gov/31697794
Autor:
Ancy D. Nalli, Curtis J. Henrich, Lauren E. Brown, John A. Porco, Thomas J. Sayers, Cheryl L. Thomas
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs. However, these have not been extensively analyzed as TRAI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db110d8d5350c2ab8796cf35de017afa
https://pubmed.ncbi.nlm.nih.gov/30504817
https://pubmed.ncbi.nlm.nih.gov/30504817
Autor:
Karnam S. Murthy, Derek M. Kendig, Hongxia Wang, John R. Grider, Sayak Bhattacharya, Ancy D. Nalli
Hydrogen sulfide (H2S), like nitric oxide (NO), causes smooth muscle relaxation, but unlike NO, does not stimulate soluble guanylyl cyclase (sGC) activity and generate cyclic guanosine 5′-monophosphate (cGMP). The aim of this study was to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f901c60c75a8a41e316447d931c21de6
https://europepmc.org/articles/PMC5668569/
https://europepmc.org/articles/PMC5668569/
Autor:
Karnam S. Murthy, Senthilkumar Rajagopal, Sunila Mahavadi, Wenhui Hu, Divya P. Kumar, Ancy D. Nalli, John R. Grider, Sayak Bhattacharya
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 352:509-518
The effect of proinflammatory cytokines on the expression and activity of soluble guanylyl cyclase (sGC) and cGMP-phosphodiesterases (PDEs) was determined in intestinal longitudinal smooth muscle. In control muscle cells, cGMP levels are regulated vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e03cf12b259cd5c360dff5de108c9e
https://doi.org/10.1124/jpet.114.221929
https://doi.org/10.1124/jpet.114.221929
Autor:
John F. Kuemmerle, Karnam S. Murthy, Othman Al-Shboul, Ancy D. Nalli, Divya P. Kumar, Sunila Mahavadi, John R. Grider, Reem Alkahtani
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:89-98
Recent studies have identified AMP-activated kinase (AMPK) as a target of Ca(2+)/calmodulin-dependent kinase kinase (CaMKKβ) and a negative regulator of myosin light-chain (MLC) kinase (MLCK). The present study examined whether a change in expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc2d0fce8ce0dfab4dc39dc3bccd308
https://doi.org/10.1124/jpet.113.212522
https://doi.org/10.1124/jpet.113.212522
Autor:
John A. Porco, Lauren E. Brown, Thomas J. Sayers, Ancy D. Nalli, Curtis J. Henrich, Cheryl L. Thomas
Publikováno v:
Cancer Research. 78:3903-3903
Induction of cancer cell-specific apoptosis via activation of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) signaling has been an attractive goal for cancer therapeutics. However, many tumor cells develop resistance to TRAIL. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bcc0471a39e630291f8271e65f16dbd
https://doi.org/10.1158/1538-7445.am2018-3903
https://doi.org/10.1158/1538-7445.am2018-3903
Publikováno v:
American journal of physiology. Cell physiology. 308(6)
Inhibitory neurotransmitters, chiefly nitric oxide and vasoactive intestinal peptide, increase cyclic nucleotide levels and inhibit muscle contraction via inhibition of myosin light chain (MLC) kinase and activation of MLC phosphatase (MLCP). H2S pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05574692f5a04a6e6b15b780232f4718
https://pubmed.ncbi.nlm.nih.gov/25567809
https://pubmed.ncbi.nlm.nih.gov/25567809