Výsledky vyhledávání - "Anco C, Molijn"

Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women

Autor: Lisanne, Verhoef, Maaike C G, Bleeker, Nicole, Polman, Renske D M, Steenbergen, Chris J L M, Meijer, Willem J G, Melchers, Ruud L, Bekkers, Anco C, Molijn, Wim G, Quint, Folkert J, van Kemenade, Johannes, Berkhof, Daniëlle A M, Heideman

Publikováno v: International Journal of Cancer. 150(3):440-449

Methylation of host-cell deoxyribonucleic acid (DNA) has been proposed as a promising biomarker for triage of high-risk (hr) human papillomavirus (HPV) positive women at screening. Our study aims to validate recently identified host-cell DNA methylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7cb5fd2dff9c8e364010d6a3bdc7da7c
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85117139739&origin=inward

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Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening

Autor: Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Renée M. F. Ebisch, Willem J. G. Melchers, Ruud L. M. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert van Kemenade, Chris J. L. M. Meijer, Johannes Berkhof, Daniëlle A. M. Heideman

Publikováno v: British Journal of Cancer. Nature Publishing Group
British Journal of Cancer, 129, 1, pp. 104-111
Verhoef, L, Bleeker, M C G, Polman, N, Steenbergen, R D M, Ebisch, R M F, Melchers, W J G, Bekkers, R L M, Molijn, A C, Quint, W G, van Kemenade, F, Meijer, C J L M, Berkhof, J & Heideman, D A M 2023, ' Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening ', British Journal of Cancer, vol. 129, no. 1, pp. 104-111 . https://doi.org/10.1038/s41416-023-02277-z

Background Host-cell DNA methylation analysis can be used to triage women with high-risk human papillomavirus (HPV)-positive self-collected cervicovaginal samples, but current data are restricted to under-/never-screened women and referral population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddaf853b778f2adcf6bdb1a7bc6ec8b
http://www.scopus.com/inward/record.url?scp=85153614201&partnerID=8YFLogxK

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The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consesus sequence

Autor: Gerard Grosveld, Magda A. Meester-Smoor, Ellen C. Zwarthoff, Nicole A. Groen, Diny van Dalsum-Verbiest, Yixian Zhao, Cora A.H. Groffen, Anco C. Molijn, Merel W. Boogaard

Publikováno v: Journal of Molecular Endocrinology. 38(1-2):113-125

The IGF-binding protein (IGFBP) family consists of six proteins that are expressed and secreted in different tissues. The proteins are regulators of physiological processes throughout the body by modulating the activity of IGF-I and IGF-II. In this a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e10bd3d557c33ae992f2e1a006d6ac2
https://pure.eur.nl/en/publications/653e77e3-4249-454a-bd65-32ff22eda536

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The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription

Autor: Gerard Grosveld, Arjan Buijs, Karel H. M. van Wely, Magda A. Meester-Smoor, Albert Jan Aarnoudse, Anita Hellemons, Ellen C. Zwarthoff, Pim den Besten, Anco C. Molijn

Publikováno v: Oncogene. 22:699-709

The t(12;22) creates an MN1-TEL fusion gene leading to acute myeloid leukemia. The fusion partner TEL (ETV6) is a member of the ETS family of transcription factors. The nature of the other fusion partner, MN1, has not been investigated in detail unti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea79f068ee2a6f70b4c9e45982ab60e
https://doi.org/10.1038/sj.onc.1206124

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Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton

Autor: Ellen C. Zwarthoff, Magda A. Meester-Smoor, Karel H. M. van Wely, A. C. P. Hekman, Marcel Vermeij, Christl Vermey-Keers, Marjolein J. L. van Helmond, Anco C. Molijn, Peter Riegman

Publikováno v: Molecular and Cellular Biology, 25(10), 4229-4236. American Society for Microbiology

Fusion of the MN1 gene to TEL (ETV6) results in myeloid leukemia. The fusion protein combines the transcription activating domain of MN1 and the DNA binding domain of TEL and is thought to act as a deranged transcription factor. In addition, disrupti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c405dcc7a1c08a469b45a9aa70c9218e
https://pubmed.ncbi.nlm.nih.gov/15870292

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The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity

Autor: Martine F. Roussel, Mark D. Potter, Alfred C.O. Vertegaal, Gerard Grosveld, Anco C. Molijn, J. Nathan Davis, Sjozef van Baal, Constantin Adams, Luc Van Rompaey, Ellen C. Zwarthoff, Arjan Buijs

Publikováno v: Molecular and Cellular Biology, 20(24), 9281-9293. American Society for Microbiology

The Tel gene (or ETV6) is the target of the translocation (12;22)(p13;q11) in myeloid leukemia. TEL is a member of the ETS family of transcription factors and contains the pointed protein interaction (PNT) domain and an ETS DNA binding domain (DBD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d6ff4f760fc1a291c3925d795a78ac
https://pure.eur.nl/en/publications/19c6c18e-aaf8-408f-aeae-72514b971685

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ACTIVATION OF G-PROTEINS BY RECEPTOR-STIMULATED NUCLEOSIDE DIPHOSPHATE KINASE IN DICTYOSTELIUM

Autor: Anco C. Molijn, Anthony A. Bominaar, van Peter Haastert, Martine Pestel, Michel Veron

Publikováno v: EMBO Journal, 12(6), 2275-2279. Wiley

Recently, interest in the enzyme nucleoside diphosphate kinase (EC2.7.4.6) has increased as a result of its possible involvement in cell proliferation and development. Since NDP kinase is one of the major sources of GTP in cells, it has been suggeste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e8a032ef60972a80da6c2e02f49322
https://research.rug.nl/en/publications/9aebfb21-8775-4412-8821-ae7f518bd0a4

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