Synergistic Effect of Serotonin 1A and Serotonin 1B/D Receptor Agonists in the Treatment of L-DOPA-Induced Dyskinesia in 6-Hydroxydopamine-Lesioned Rats

Autor: Anca Stoica, Hansen John Bondo, Jens D. Mikkelsen, Kenneth Vielsted Christensen, Mikael S. Thomsen

BackgroundThe gold standard for symptomatic relief of Parkinson’s disease is L-DOPA. However, long-term treatment often leads to motor complications such as L-DOPA-induced dyskinesia (LID). While amantadine (Gocovri™) is the only approved therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71331a9965e8348a3046a60e058fc977
https://doi.org/10.1101/2021.08.31.458314

Cotransporter-mediated water transport underlying cerebrospinal fluid formation

Autor: Niklas J. Gerkau, Katerina Tritsaris, Nanna MacAulay, Eva Kjer Oernbo, Anca Stoica, Christine R. Rose, Dagne Barbuskaite, Annette Buur Steffensen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Steffensen, A B, Oernbo, E K, Stoica, A, Gerkau, N J, Barbuskaite, D, Tritsaris, K, Rose, C R & MacAulay, N 2018, ' Cotransporter-mediated water transport underlying cerebrospinal fluid formation ', Nature Communications, vol. 9, no. 1, 2167 . https://doi.org/10.1038/s41467-018-04677-9
Nature Communications

Cerebrospinal fluid (CSF) production occurs at a rate of 500 ml per day in the adult human. Conventional osmotic forces do not suffice to support such production rate and the molecular mechanisms underlying this fluid production remain elusive. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c2ef40837deacbe218e2f37c32de8d
https://doaj.org/article/543501b1f622450685d52b070f2b2f83

The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

Autor: Brian Roland Larsen, Michelle L. Olsen, Rikke Holm, Nanna MacAulay, Leanne M. Holt, Karin Lykke-Hartmann, Anca Stoica, Mette Assentoft, Bente Vilsen, Frederik Vilhardt

Publikováno v: Stoica, A, Larsen, B, Assentoft, M, Jensen, R H, Holt, L, Vilhardt, F, Vilsen, B, Lykke-Hartmann, K & MacAulay, N 2017, ' The α2β2 isoform combination dominates the astrocytic Na+ /K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. ', Glia, vol. 65, no. 11, pp. 1777-1793 . https://doi.org/10.1002/glia.23194

Synaptic activity results in transient elevations in extracellular K+ , clearance of which is critical for sustained function of the nervous system. The K+ clearance is, in part, accomplished by the neighboring astrocytes by mechanisms involving the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43528804b25db705b2078a10ffcb480
https://doi.org/10.1002/glia.23194

Astrocytic Na,K-ATPase a2b1 and a2b2 manages [K+]o differently during synaptic activity. Poster at the 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan, 2017

Autor: Brian Roland Larsen, Anca Stoica, Mette Assentoft, Rikke Holm Jensen, Holt, Leanne M., Karin Lykke-Hartmann, Olsen, Michelle L., Bente Vilsen, Nanna MacAulay

Publikováno v: Larsen, B R, Stoica, A, Assentoft, M, Jensen, R H, Holt, L M, Lykke-Hartmann, K, Olsen, M L, Vilsen, B & MacAulay, N 2017, ' Astrocytic Na,K-ATPase a2b1 and a2b2 manages [K+]o differently during synaptic activity. Poster at the 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan, 2017 ' .
Aarhus University

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6dc0cf865474523ecc1705c995ab591c
https://pure.au.dk/portal/da/publications/astrocytic-nakatpase-a2b1-and-a2b2-manages-ko-differently-during-synaptic-activity-poster-at-the-15th-international-conference-on-nakatpase-and-related-transport-atpases-otsu-japan-2017(29dd31f1-0c06-431f-81a7-869204a3d123).html

Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+/K+-ATPase Subunit Isoforms

Autor: Brian Roland Larsen, Anca Stoica, Nanna MacAulay

Publikováno v: Larsen, B R, Stoica, A & MacAulay, N 2016, ' Managing Brain Extracellular K(+) during Neuronal Activity : The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms ', Frontiers in Physiology, vol. 7, 141 . https://doi.org/10.3389/fphys.2016.00141
Frontiers in Physiology, Vol 7 (2016)
Frontiers in Physiology

During neuronal activity in the brain, extracellular K(+) rises and is subsequently removed to prevent a widespread depolarization. One of the key players in regulating extracellular K(+) is the Na(+)/K(+)-ATPase, although the relative involvement an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3568ac6fde3fb00182a1e01e6d88c7d0
https://doi.org/10.3389/fphys.2016.00141