Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anca Mihalas"'
Publikováno v:
Neuro Oncol
Single cell RNA-seq (scRNA-seq) studies for glioma have yielded critical insight into intratumoral heterogeneity and developmental gene expression patterns for primary gliomas. One key conclusion from these studies is that each tumor represents a com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf42308964053a5e33a960444a9e8b2
https://europepmc.org/articles/PMC8598814/
https://europepmc.org/articles/PMC8598814/
Autor:
Anca Mihalas, Sonali Arora, Samantha O'Connor, Heather Feldman, Anoop Patel, Patrick Paddison
Publikováno v:
Neuro-Oncology. 24:vii37-vii37
Glioblastoma, the most aggressive type of primary brain cancer, benefits little from standard of care therapy. Over the past few decades not much advancement has been made in improving the recurrence-free survival after treatment, with a median survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5cbb1dbe2eb9ab5d17754444d3a5544
https://doi.org/10.1093/neuonc/noac209.146
https://doi.org/10.1093/neuonc/noac209.146
Autor:
Kavya Kannan, Anoop P. Patel, Anca Mihalas, Adrián López García de Lomana, Wei-Ju Wu, James H. Park, Abdullah H. Feroze, Dirk C. Keene, Samuel Emerson, Serdar Turkarslan, Nitin S. Baliga, Patrick J. Cimino
Publikováno v:
Neuro-Oncology. 23:vi6-vi7
Glioblastoma is a heterogeneous tumor made up of cell states that evolve over time. We modeled tumor evolutionary trajectories during standard-of-care treatment using multimodal single-cell analysis of a primary tumor sample, corresponding mouse xeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6192be1f37900c9454e3821aa3401b0c
https://doi.org/10.1093/neuonc/noab196.022
https://doi.org/10.1093/neuonc/noab196.022
Autor:
Nitin S. Baliga, Wei-Ju Wu, Patrick J. Cimino, James H. Park, A. Lopez Garcia de Lomana, Serdar Turkarslan, Christopher Dirk Keene, K. Kannan, Anca Mihalas, Samuel Emerson, Abdullah H. Feroze, Anoop P. Patel
Glioblastoma (GBM) is a heterogeneous tumor made up of cell states that evolve over time. Here, we modeled tumor evolutionary trajectories during standard-of-care treatment using multimodal single-cell analysis of a primary tumor sample, correspondin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86e477fd3e23b8c174f930b7042d2d41
https://doi.org/10.1101/2021.01.13.426485
https://doi.org/10.1101/2021.01.13.426485
Autor:
Anoop P. Patel, Ye Zheng, Raphael Gottardo, Abdullah H. Feroze, Samuel Emerson, Scott N. Furlan, Jay F. Sarthy, Kalee Carson, Steven J. Wu, Hatice S. Kaya-Okur, Patrick J. Cimino, C. Dirk Keene, Kami Ahmad, Anca Mihalas, Steven Henikoff
Publikováno v:
Nat Biotechnol
Methods for quantifying gene expression1 and chromatin accessibility2 in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been technically challenging. In this study, we adapted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea404f725ed9806b003544bef682c7d
https://pubmed.ncbi.nlm.nih.gov/33846646
https://pubmed.ncbi.nlm.nih.gov/33846646
Autor:
Anca Mihalas, Anoop P. Patel, John Bassett, Heather Feldman, Sonali Arora, Patrick J. Paddison
Publikováno v:
Neuro Oncol
Current standard of care therapy for glioblastoma (GB) includes cytoreduction followed by ablative therapies that target rapidly dividing cell types. However, non-cycling, quiescent-like states (G0 phase cells) are present in both normal tissue and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1879c679831e4d44ff403243edcce3
https://doi.org/10.1093/neuonc/noab196.112
https://doi.org/10.1093/neuonc/noab196.112
Publikováno v:
Neuro Oncol
Current standard of care therapy for glioblastoma (GBM) includes cytoreduction followed by ablative therapies that target rapidly dividing cell types. However, the presence of quiescent-like/G0 states, therefore, represents a natural reservoir of tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed4b41b00bccd0da8d345d5fdeaf2a3
https://doi.org/10.1093/neuonc/noaa215.079
https://doi.org/10.1093/neuonc/noaa215.079
CBMT-42. A GENOME-WIDE CRISPR-Cas9 SCREEN FOR GENES REGULATING QUIESCENT-LIKE STATES IN GLIOBLASTOMA
Publikováno v:
Neuro Oncol
Current standard of care therapy for glioblastoma (GBM) includes cytoreduction followed by ablative therapies that target rapidly dividing cell types. However, non-cycling, quiescent-like states (G0 phase cells) are present in both normal tissue and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506f8afaf87adac9b93d7bc25db38598
https://doi.org/10.1093/neuonc/noz175.164
https://doi.org/10.1093/neuonc/noz175.164