Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Anbarasu Lourdusamy"'
Autor:
Franziska Linke, James E. C. Johnson, Stefanie Kern, Christopher D. Bennett, Anbarasu Lourdusamy, Daniel Lea, Steven C. Clifford, Catherine L. R. Merry, Snow Stolnik, Morgan R. Alexander, Andrew C. Peet, David J. Scurr, Rian L. Griffiths, Anna M. Grabowska, Ian D. Kerr, Beth Coyle
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract The most common malignant brain tumour in children, medulloblastoma (MB), is subdivided into four clinically relevant molecular subgroups, although targeted therapy options informed by understanding of different cellular features are lacking
Externí odkaz:
https://doaj.org/article/8e0594bb9b0f4ee79da8bd0f140e5dd2
Autor:
Huda Alfardus, Maria de los Angeles Estevez-Cebrero, Jonathan Rowlinson, Amna Aboalmaaly, Anbarasu Lourdusamy, Salah Abdelrazig, Catherine Ortori, Richard Grundy, Dong-Hyun Kim, Alan McIntyre, Stuart Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract While specific microRNA (miRNA) signatures have been identified in glioblastoma (GBM), the intratumour heterogeneity in miRNA expression has not yet been characterised. In this study, we reveal significant alterations in miRNA expression acr
Externí odkaz:
https://doaj.org/article/70c79d13cb784e25885855238a077df2
Autor:
Alexandra D. Rusu, Zoe E. Cornhill, Brenda Canales Coutiño, Marcos Castellanos Uribe, Anbarasu Lourdusamy, Zsuzsa Markus, Sean T. May, Ruman Rahman, Marios Georgiou
Publikováno v:
Open Biology, Vol 11, Iss 9 (2021)
Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established role
Externí odkaz:
https://doaj.org/article/ac1db539b5b844c9955fe2fded805808
Autor:
Brenda Canales Coutiño, Zoe E. Cornhill, Africa Couto, Natalie A. Mack, Alexandra D. Rusu, Usha Nagarajan, Yuen Ngan Fan, Marina R. Hadjicharalambous, Marcos Castellanos Uribe, Amy Burrows, Anbarasu Lourdusamy, Ruman Rahman, Sean T. May, Marios Georgiou
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101237- (2020)
Summary: Metastasis is the leading cause of death for patients with cancer. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumor growth toward malignancy. Advances in genome ch
Externí odkaz:
https://doaj.org/article/63857e0e94984fed9ef235e03070465b
Autor:
Omar J. Mohammed, Maria Estevez Cebrero, Omar Ahmad, Andrew Peet, Richard G. Grundy, Anbarasu Lourdusamy
Publikováno v:
Cancers, Vol 14, Iss 1, p 251 (2022)
Medulloblastoma (MB) is a childhood malignant brain tumour but also occurs in teenagers and young adults (TYA). Considering that MB is heterogeneous, this study aimed to define the molecular landscape of MBs in TYAs. We collated more than 2000 MB sam
Externí odkaz:
https://doaj.org/article/4a8c6dfbe7864faa8afe6c97bf84acd9
Autor:
Agathe L. Chédeville, Anbarasu Lourdusamy, Ana Rita Monteiro, Richard Hill, Patricia A. Madureira
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 310 (2020)
Glioblastoma (GB) is the most common and deadly type of primary malignant brain tumor with an average patient survival of only 15–17 months. GBs typically have hypoxic regions associated with aggressiveness and chemoresistance. Using patient derive
Externí odkaz:
https://doaj.org/article/557a3485eaf04f93a8f40719c172c5d3
Autor:
Elin S. Blom, Yijing Wang, Lena Skoglund, Anita C. Hansson, Massimo Ubaldi, Anbarasu Lourdusamy, Wolfgang H. Sommer, Matthew Mielke, Bradley T. Hyman, Markus Heilig, Lars Lannfelt, Lars N. G. Nilsson, Martin Ingelsson
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microar
Externí odkaz:
https://doaj.org/article/d9bbda63616845afba269724ed317840
Autor:
Abdolrahman S. Nateri, Axel Behrens, Anbarasu Lourdusamy, Mohammad Ilyas, Bradley Spencer-Dene, Seyed Hossein Kashfi, Anas Saadeddin, Emenike K. Onyido, Roya Babaei-Jadidi, Sheema Almozyan, Belal A. Muhammad
S6. FLYWCH1 mutation in human cancers and analysis of cell cycle by flow cytometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3d07b8d9c77d298d70b0ca562bdbd3
https://doi.org/10.1158/1541-7786.22515355.v1
https://doi.org/10.1158/1541-7786.22515355.v1
Autor:
Abdolrahman S. Nateri, Axel Behrens, Anbarasu Lourdusamy, Mohammad Ilyas, Bradley Spencer-Dene, Seyed Hossein Kashfi, Anas Saadeddin, Emenike K. Onyido, Roya Babaei-Jadidi, Sheema Almozyan, Belal A. Muhammad
This file contains Supplementary Figures 1-9 legends, and Supplementary Tables 1 & 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001daa802bfac3be7cb3f9122b088045
https://doi.org/10.1158/1541-7786.22515343
https://doi.org/10.1158/1541-7786.22515343
Autor:
Abdolrahman S. Nateri, Axel Behrens, Anbarasu Lourdusamy, Mohammad Ilyas, Bradley Spencer-Dene, Seyed Hossein Kashfi, Anas Saadeddin, Emenike K. Onyido, Roya Babaei-Jadidi, Sheema Almozyan, Belal A. Muhammad
Wnt/β-catenin signaling plays a critical role during development of both normal and malignant colorectal cancer tissues. Phosphorylation of β-catenin protein alters its trafficking and function. Such conventional allosteric regulation usually invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c75e90b04da8215776b9e8f9c281735
https://doi.org/10.1158/1541-7786.c.6541051
https://doi.org/10.1158/1541-7786.c.6541051