Erratum in: Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose Cancer stem cells (CSCs) are known to contribute to tumor relapses by virtue of their chemoresistance. With the knowledge that nanoformulations can overcome drug resistance, we evaluated the efficacy and cytotoxicity of clinical-grade carbopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e1374064ee376f2002ac8f75e6ab17b
https://pubmed.ncbi.nlm.nih.gov/34784412

Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas

Autor: Steffen Heegaard, Mikkel Funding, Ingvild Ramberg, Christian von Buchwald, Filipe G. Vieira, Finn Cilius Nielsen, Peter B. Toft

Publikováno v: Investigative Ophthalmology & Visual Science
Ramberg, I, Vieira, F G, Toft, P B, Von Buchwald, C, Funding, M, Nielsen, F C & Heegaard, S 2021, ' Genomic alterations in human papillomavirus-positive and-negative conjunctival squamous cell carcinomas ', Investigative Ophthalmology and Visual Science, vol. 62, no. 14, 11 . https://doi.org/10.1167/iovs.62.14.11

PURPOSE. The genomic alterations contributing to the pathogenesis of conjunctival squamous cell carcinomas (SCCs) and their precursor lesions are poorly understood and hamper our ability to develop molecular therapies to reduce the recurrence rates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47778d7c3987dd8276471f273b11303
https://pubmed.ncbi.nlm.nih.gov/34779821

Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma

Autor: Katherine M. Curt, Joanna R. Thomas, Susan E. Bates, Christina M. Fitzsimmons, Michael M. Gottesman, Ruchi P. Patel, Robert W. Robey, Pedro J. Batista

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose Over 90% of uveal melanomas harbor pathogenic variants of the GNAQ or GNA11 genes that activate survival pathways. As previous studies found that Ras-mutated cell lines were vulnerable to a combination of survival pathway inhibitors and the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7996652ba158073425340ab8c926306d
http://europepmc.org/articles/PMC8458781

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

Autor: Mohamed H. Abdel-Rahman, Getachew Boru, Klarke M. Sample, Frederick H. Davidorf, James B. Massengill, Colleen M. Cebulla

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose The activation of the mitogen-activated protein kinase (MAPK) pathway has been suggested as the major downstream target when GNAQ and GNA11 (GNAQ/11) are mutated in uveal melanoma (UM). However, clinical trials with single agent MEK inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5d24c3abce6d25c308e847697ea932
http://europepmc.org/articles/PMC6557618

Aurora Kinase B Expression, Its Regulation and Therapeutic Targeting in Human Retinoblastoma

Autor: Swatishree Sradhanjali, Mamatha M. Reddy, Sunil K. Raghav, Swathi Kaliki, Devjyoti Tripathy, Manas Ranjan Barik, Ruchi Mittal, Atimukta Jha, Naheed Arfin Borah, Suryasnata Rath, Srinivas Patnaik

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose Aurora kinase B (AURKB) plays a pivotal role in the regulation of mitosis and is gaining prominence as a therapeutic target in cancers; however, the role of AURKB in retinoblastoma (RB) has not been studied. The purpose of this study was to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd36d34396100179e8864f077979a00
https://pubmed.ncbi.nlm.nih.gov/33704359