Výsledky vyhledávání - "Anatomy::Cells::Stem Cells::Neoplastic Stem Cells [Medical Subject Headings]"

Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells

Autor: Daniel Otero-Albiol, Sandra Muñoz-Galván, Eva M. Verdugo-Sivianes, Amancio Carnero, Ana M. Rojas

Publikováno v: Theranostics
Digital.CSIC. Repositorio Institucional del CSIC
instname

[Rationale] SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression and malignancy of different tumors depending on its association with protein phosphatase 1 (PP1) and the ability of the PP1-SPN holoenzyme to dephosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc94057a330544993a83e9fc556b68b2
http://europepmc.org/articles/PMC7847670

Zobrazit plný text záznamu

ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

Autor: Silvia Redondo-García, Juan Carlos Rodríguez-Manzaneque, Orlando Serrano-Garrido, Helena G Asenjo, Carlos Peris-Torres, Jose L. Fernandez-Luna, María del Carmen Plaza-Calonge

Publikováno v: Biomolecules, Vol 11, Iss 44, p 44 (2021)
Biomolecules
Volume 11
Issue 1

Gliomas in general and the more advanced glioblastomas (GBM) in particular are the most usual tumors of the central nervous system with poor prognosis. GBM patients develop resistance to distinct therapies, in part due to the existence of tumor cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347ef396f4c3245e71d11f693f0eb16b
https://www.mdpi.com/2218-273X/11/1/44

Zobrazit plný text záznamu

Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis

Autor: Daniel Otero-Albiol, Antonio Lucena-Cacace, Manuel P. Jiménez-García, Amancio Carnero

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)

[Background] Sarcomas are a very heterogeneous group of tumors with intrinsic developmental programs derived from the cell of origin. This implies a functional hierarchy inside tumors governed by sarcoma stem cells. Therefore, genetic and/or epigenet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c259fa769ae7a79e1f5a9062bf99665
http://europepmc.org/articles/PMC8348834

Zobrazit plný text záznamu

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

© The Author(s) 2021.
[Background]: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3595702adbd34870bba805930ff53097
https://doi.org/10.21203/rs.3.rs-527836/v1

Zobrazit plný text záznamu

Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle

Autor: Verdugo-Sivianes, Eva M., Carnero, Amancio

Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance in the action of kinases, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::7f9b5c4613a8db5734855489c460d58f
https://hdl.handle.net/10668/4331

Zobrazit plný text záznamu

Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress

Autor: Ortíz, Raúl, Quiñonero, Francisco, García-Pinel, Beatriz, Fuel, Marco, Mesas, Cristina, Cabeza, Laura, Melguizo, Consolación, Prados, Jose

The development of drug resistance is one of the main causes of cancer treatment failure. This phenomenon occurs very frequently in different types of cancer, including colon and pancreatic cancers. However, the underlying molecular mechanisms are no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::cac7d34aee09b938c622e3718316264b
https://hdl.handle.net/10668/4177

Zobrazit plný text záznamu

Targeting Protein Kinase C in Glioblastoma Treatment

Autor: Geribaldi-Doldán, Noelia, Hervás-Corpión, Irati, Gómez-Oliva, Ricardo, Domínguez-García, Samuel, Ruiz, Félix A., Iglesias-Lozano, Irene, Carrascal, Livia, Pardillo-Díaz, Ricardo, Gil-Salú, José L., Nunez-Abades, Pedro, Valor, Luis M., Castro, Carmen

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::bc54ec66843bcafa09f7a3278d535ee8
https://hdl.handle.net/10668/4420

Zobrazit plný text záznamu

Evolution of Experimental Models in the Study of Glioblastoma: Toward Finding Efficient Treatments

Autor: Gómez-Oliva, Ricardo, Domínguez-García, Samuel, Carrascal, Livia, Abalos-Martínez, Jessica, Pardillo-Díaz, Ricardo, Verástegui, Cristina, Castro, Carmen, Nunez-Abades, Pedro, Geribaldi-Doldán, Noelia

Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to conventional therapies, including temozolomide, the most widely used chemotherapeutic agent in the treatment of GBM. Within the tumor, the presence of glioma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::48986bfe3d8c73524bce89359af43178
https://hdl.handle.net/10668/4110

Zobrazit plný text záznamu

Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2

Autor: Antonio Lucena-Cacace, Amancio Carnero, Manuel P. Jiménez-García, Daniel Otero-Albiol

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)

The EMX (Empty Spiracles Homeobox) genes EMX1 and EMX2 are two homeodomain gene members of the EMX family of transcription factors involved in the regulation of various biological processes, such as cell proliferation, migration, and differentiation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86d8e75b38b9a76d96fafa738c3d341
http://hdl.handle.net/10261/265103

Zobrazit plný text záznamu

The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study

Autor: Laura Cabeza, Raúl Ortiz, Gloria Perazzoli, Jose Prados, Kevin Doello, Consolación Melguizo, Francisco Quiñonero, Cristina Mesas

Publikováno v: Cancers
Volume 13
Issue 13
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cancers, Vol 13, Iss 3169, p 3169 (2021)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

Sodium selenite acts by depleting enzymes that protect against cellular oxidative stress. To determine its effect alone or in combination with gemcitabine (GMZ) in pancreatic cancer, we used PANC-1 and Pan02 cell lines and C57BL mice bearing a Pan02-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f2843853b048b6507ff3a25ea78f3c
http://hdl.handle.net/10481/69466

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání