Výsledky vyhledávání - "Anatoly Severin"

High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4)

Autor: Marilyn Chung, Som S. Chatterjee, Eun Ju Choo, Li Basuino, Anatoly Severin, Natalie C. J. Strynadka, J. Andrew N. Alexander, Thaina Miranda da Costa, Stephanie M. Hamilton, Henry F. Chambers, Alexander Tomasz, Sandra Aedo

Publikováno v: Antimicrobial Agents and Chemotherapy. 61

Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus , has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f114cc632243a91dab56631429917d3f
https://doi.org/10.1128/aac.02727-16

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Pyrazolidine-3,5-diones and 5-Hydroxy-1H-pyrazol-3(2H)-ones, Inhibitors of UDP-N-acetylenolpyruvyl Glucosamine Reductase

Autor: David Keeney, Alan H. Katz, Guy Singh, Jay Scott Shumsky, Anatoly Severin, Youjun Yang, Adam M. Gilbert, William Hu, Amedeo Arturo Failli, Peter Petersen

Publikováno v: Journal of Medicinal Chemistry. 49:6027-6036

A series of pyrazolidine-3,5-dione and 5-hydroxy-1H-pyrazol-3(2H)-one inhibitors of Escherichia coli UDP-N-acetylenolpyruvyl glucosamine reductase (MurB) has been prepared. The 5-hydroxy-1H-pyrazol-3(2H)-ones show low micromolar IC(50) values versus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b0badc848f5bbaa02003af14e5b1a6
https://doi.org/10.1021/jm060499t

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High-Level β-Lactam Resistance and Cell Wall Synthesis Catalyzed by the mecA Homologue of Staphylococcus sciuri Introduced into Staphylococcus aureus

Autor: Alexander Tomasz, Shang Wei Wu, Keiko Tabei, Anatoly Severin

Publikováno v: Journal of Bacteriology. 187:6651-6658

A close homologue of mecA , the determinant of broad-spectrum β-lactam resistance in Staphylococcus aureus was recently identified as a native gene in the animal commensal species Staphylococcus sciuri . Introduction of the mecA homologue from a met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88b8760275d1828ec0515793d61db0e
https://doi.org/10.1128/jb.187.19.6651-6658.2005

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4-Alkyl and 4,4′-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis

Autor: Guy Singh, Girija Krishnamurthy, Jamie M. Davis, Kristina M.K. Kutterer, William Hu, Youjun Yang, Alan H. Katz, Anatoly Severin, Beth A. Rasmussen, Amedeo Arturo Failli

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:2527-2531

Over 195 4-alkyl and 4,4-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives were synthesized, utilizing microwave accelerated synthesis, for evaluation as new inhibitors of bacterial cell wall biosynthesis. Many of them demonstrated go

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5256af400e9995e16ee48145b274f
https://doi.org/10.1016/j.bmcl.2005.03.058

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Identification of Factor XIIIa-Reactive Glutamine Acceptor and Lysine Donor Sites within Fibronectin-Binding Protein (FnbA) from Staphylococcus aureus

Autor: Ellen Murphy, Leah D. Fletcher, Yury V. Matsuka, Anatoly Severin, Elizabeth T. Anderson, Steven Morris Baker

Publikováno v: Biochemistry. 43:11842-11852

Staphylococcal fibronectin-binding protein (FnbA) is a surface-associated receptor responsible for the reversible binding of bacteria to human fibronectin and fibrin(ogen). Recently we have shown that FnbA serves as a substrate for coagulation factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453583dc72b7479b6ad5ec9ad69103b0
https://doi.org/10.1021/bi049278k

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2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis

Autor: Pornpen Labthavikul, Peter Petersen, Tarek S. Mansour, Guy Singh, Beth A. Rasmussen, Jerauld S. Skotnicki, Gerardo D. Francisco, William Hu, Youjun Yang, Yang-I Lin, Zhong Li, Anatoly Severin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:2591-2594

Twenty-five 2-phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives were synthesized for evaluation as new inhibitors of bacterial cell wall biosynthesis. Many of them demonstrated good inhibitory activity against Staphylococcus aureus MurB, Mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ed4dae9e41d284502531533dc4ccff
https://doi.org/10.1016/s0960-894x(03)00471-2

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Synthesis of the l-Alanyl-l-alanine Cross-bridge of Enterococcus faecalis Peptidoglycan

Autor: Dominique Mengin-Lecreulx, Anatoly Severin, Nathalie Josseaume, David M. Shlaes, Ahmed Bouhss, Keiko Tabei, Jean van Heijenoort, Michel Arthur, Jean-Emmanuel Hugonnet

Publikováno v: Journal of Biological Chemistry. 277:45935-45941

The enzymatic synthesis of the complete l-alanyl(1)-l-alanine(2) side chain of the peptidoglycan precursors of Enterococcus faecalis was obtained in vitro using purified enzymes. The pathway involved alanyl-tRNA synthetase and two ligases, BppA1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469cc58d2f2ae79600f8530063251d8a
https://doi.org/10.1074/jbc.m207449200

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Further Evidence that a Cell Wall Precursor [C 55 -MurNAc-(Peptide)-GlcNAc] Serves as an Acceptor in a Sorting Reaction

Autor: Marshall M. Siegel, Guy Singh, Steven J. Projan, Alexey Ruzin, Keiko Tabei, Patricia A. Bradford, David M. Shlaes, Frank Ritacco, Anatoly Severin

Publikováno v: Journal of Bacteriology. 184:2141-2147

Previous studies suggested that a Gly-containing branch of cell wall precursor [C 55 -MurNAc-(peptide)-GlcNAc], which is often referred to as lipid II, might serve as a nucleophilic acceptor in sortase-catalyzed anchoring of surface proteins in Staph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ae24ffea517eaf0049ac253cd3af68
https://doi.org/10.1128/jb.184.8.2141-2147.2002

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Antibacterial efficacy of nisin against multidrug-resistant Gram- positive pathogens

Autor: Anatoly Severin, Elena Severina, Alexander Tomasz

Publikováno v: Journal of Antimicrobial Chemotherapy. 41:341-347

The rapid spread of multidrug-resistant bacterial pathogens necessitates the search for alternative antibacterial agents. We examined the efficacy of the antibiotic nisin against 56 multidrug-resistant isolates of Streptococcus pneumoniae, 33 Staphyl

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https://doi.org/10.1093/jac/41.3.341

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Abnormal physiological properties and altered cell wall composition in Streptococcus pneumoniae grown in the presence of clavulanic acid

Autor: Elena Severina, Anatoly Severin, A Tomasz

Publikováno v: Scopus-Elsevier

Subinhibitory concentrations of clavulanate caused premature induction of stationary-phase autolysis, sensitization to lysozyme, and reductions in the MICs of deoxycholate and penicillin for Streptococcus pneumoniae. In the range of clavulanate conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3c8696f2e353a4fdd112ad1d6d5c24
https://doi.org/10.1128/aac.41.3.504

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