Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Anatoly Pinchuk"'
Autor:
Joseph J. Grudzinski, Lance T. Hall, Steve Cho, Glenn Liu, Anne Traynor, Matthew H. Lee, Marc Longino, Anatoly Pinchuk, Christine Jaskowiak, Bryan Bednarz, Jamey Weichert, John S. Kuo
Publikováno v:
Radiation, Vol 2, Iss 2, Pp 215-227 (2022)
The purpose of this study was to assess organ dosimetry and clinical use of [124I]I-NM404, a radiotheranostic alkylphosphocholine (APC) analog, for accurate detection and characterization of a wide variety of solid primary and metastatic malignancies
Externí odkaz:
https://doaj.org/article/e3f05a37417341fb9f65fc1724e8f472
Autor:
Carolina A. Ferreira, Hemanth K. Potluri, Christopher Massey, Joseph J. Grudzinski, Amanda Carston, Nathan Clemons, Anna Thickens, Zachary Rosenkrans, Cynthia Choi, Anatoly Pinchuk, Ohyun Kwon, Justin J. Jeffery, Bryan Bednarz, Zachary Morris, Jamey Weichert, Douglas G. McNeel, Reinier Hernandez
An immunosuppressive tumor microenvironment has hampered the efficacy of immunotherapy in prostate cancer. However, radiation-induced immunological effects can partly mediate anti-tumor effects by promoting a pro-inflammatory environment potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae9c037930f54dd826bb23bedc42cf0b
https://doi.org/10.1101/2022.09.26.509374
https://doi.org/10.1101/2022.09.26.509374
Autor:
Tetyana Sergeyeva, Daria Yarynka, Vitaly Lytvyn, Petro Demydov, Andriy Lopatynskyi, Yevgeny Stepanenko, Oleksandr Brovko, Anatoly Pinchuk, Volodymyr Chegel
Publikováno v:
The Analyst. 147(6)
We demonstrate a novel sensor platform with enhanced sensitivity and selectivity for detecting aflatoxin B1 - a common food toxin in cereals. The approach is based on a molecularly imprinted polymer film that provides selective binding of the aflatox
Autor:
Gopal Iyer, Reinier Hernandez, Jonathan W. Engle, Ariana N. Bitton, Jamey P. Weichert, Eduardo Aluicio-Sarduy, Ravi Patel, Anatoly Pinchuk, Joseph Grudzinski, Christopher Massey, Ray R. Zhang, Aakarsha V. Rao
Publikováno v:
Journal of Nuclear Medicine
There is a clinically unmet need for effective treatments for triple-negative breast cancer (TNBC), as it remains the most aggressive subtype of breast cancer. Herein, we demonstrate a promising strategy using a tumor-targeting alkylphosphocholine (N
Autor:
Joseph J. Grudzinksi, Ronald R. Burnette, Reinier Hernandez, John S. Kuo, Anatoly Pinchuk, Ray R. Zhang, Tej I Mehta, Paul A. Clark, Justin Jeffrey, Marc Longino, Jonathan A. Lubin, Jamey P. Weichert
Publikováno v:
Molecular Pharmaceutics. 16:3350-3360
Alkylphosphocholine (APC) analogs are a novel class of broad-spectrum tumor-targeting agents that can be used for both diagnosis and treatment of cancer. The potential for clinical translation for APC analogs will strongly depend on their pharmacokin
Autor:
Jamey P. Weichert, John S. Kuo, Alexandra B. Schroeder, Kevin W. Eliceiri, Eben L. Rosenthal, Jason M. Warram, Anatoly Pinchuk, Joseph Grudzinski, Ray R. Zhang
Publikováno v:
Nature Reviews Clinical Oncology. 14:347-364
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging. Specifically, advances in fluorophore chemistry and imagi
Autor:
Zachary S. Morris, Jamey P. Weichert, Christian M. Capitini, Anatoly Pinchuk, Joseph Grudzinski, Reinier Hernandez, Eduardo Aluicio-Sarduy, Jonathan W. Engle, Christopher D. Zahm, Paul M. Sondel, Kirsti L. Walker, Ryan J. Brown, Christopher Massey, Ravi Patel, Ariana N. Bitton
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Communications Biology
Communications Biology
Finding improved therapeutic strategies against T-cell Non-Hodgkin’s Lymphoma (NHL) remains an unmet clinical need. We implemented a theranostic approach employing a tumor-targeting alkylphosphocholine (NM600) radiolabeled with 86Y for positron emi
Publikováno v:
Molecular Cancer Therapeutics. 18:C070-C070
Lipid rafts (LR) are specialized regions or microdomains within the cell membrane that are highly enriched with cholesterol and sphingolipids. The presence of LR in tumor cell membranes is as much as 10 fold higher than in normal tissue. Our phosphol
Autor:
Jamey P. Weichert, Maria Banach, Richard Tollefson, Qin C. Ji, Giangthy N. Ton, Michelle J. Cannon, Christie Scheuerell, Xiangyu Jiang, William R. Clarke, Hongliang Jiang, Anatoly Pinchuk, Marc A. Longino
Publikováno v:
Journal of Chromatography B. 878:1513-1518
A rapid and specific LC-MS/MS based bioanalytical method was developed and validated for the determination of 18-(p-iodophenyl)octadecyl phosphocholine (CLR1401), a novel phosphocholine drug candidate, in rat plasma. The optimal chromatographic behav
Autor:
Jamey P. Weichert, Milton D. Gross, Rayrnond E. Counsell, Mark A. Rampy, Marc Longino, R. W. Scott Skinner, Anatoly Pinchuk
Publikováno v:
Journal of Medicinal Chemistry. 49:2155-2165
Radioiodinated phospholipid ether analogues have shown a remarkable ability to selectively accumulate in a variety of human and animal tumors in xenograft and spontaneous tumor rodent models. It is believed that this tumor avidity arises as a consequ