Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anatoliy S. Bushnev"'
Autor:
Anatoliy S. Bushnev, Mark T. Baillie, Jason J. Holt, David S Menaldino, Alfred H. Merrill Jr., Dennis C. Liotta
Publikováno v:
ARKIVOC, Vol 2010, Iss 8, Pp 263-277 (2010)
Externí odkaz:
https://doaj.org/article/9e02da575f2e494a9beae5915b1c7b19
Autor:
Anatoliy S. Bushnev, Perry W. Bartsch, Savita Sharma, Kyle E. Giesler, Dennis C. Liotta, Eric J. Miller, Madhuri Dasari, D'erasmo Michael, Adriaan E. Basson, Soyon S. Hwang, Akshay Raghuram, Nicole Pribut, Iskandar Sabrina, Samantha L. Burton, Cynthia A. Derdeyn
Publikováno v:
Journal of Medicinal Chemistry. 64:12917-12937
Tenofovir (TFV) is the cornerstone nucleotide reverse transcriptase inhibitor (NtRTI) in many combination antiretroviral therapies prescribed to patients living with HIV/AIDS. Due to poor cell permeability and oral bioavailability, TFV is administere
Autor:
Jason J. Holt, John A. Petros, Anatoliy S. Bushnev, David S. Menaldino, Richard F. Arrendale, Lanny S. Liebeskind, Taylor J. Evers, Deborah G. Culver, G. Prabhakar Reddy, Suzanne G. Mays, Dennis C. Liotta, Mark T. Baillie, Randy B. Howard, Michael G. Natchus, Harsha Ramaraju, Ethel C. Garnier-Amblard
Publikováno v:
ACS Medicinal Chemistry Letters. 2:438-443
Enigmol is a synthetic, orally active 1-deoxysphingoid base analogue that has demonstrated promising activity against prostate cancer. In these studies, the pharmacologic roles of stereochemistry and N-methylation in the structure of enigmols were ex
Autor:
Dennis C. Liotta, Christopher A. Haynes, Anatoliy S. Bushnev, Alfred H. Merrill, Madhura Adiga, Kerri Hagedorn, M. Cameron Sullards, Sarah T. Pruett
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 8, Pp 1621-1639 (2008)
“Sphingosin” was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of “lipides derived from sphingosine as sphingolip
Autor:
Hong Yi, Suzanne G. Mays, Dennis C. Liotta, Mark T. Baillie, John A. Petros, Anatoliy S. Bushnev
Publikováno v:
The FASEB Journal. 29
Autor:
Alfred H. Merrill, David S. Menaldino, Dirck L. Dillehay, M. Cameron Sullards, Qiong Peng, Aiming Sun, Dennis C. Liotta, Anatoliy S. Bushnev, Jeremy C. Allegood, Elaine Wang, Sarah Trotman-Pruett, Holly Symolon, Kena Desai
Publikováno v:
Pharmacological Research. 47:373-381
The sphingoid base backbones of sphingolipids (sphingosines, sphinganines, 4-hydroxysphinganines and others) are highly bioactive species directly and-in most cases-as their metabolites, the N-acyl-sphingoid bases (ceramides) and sphingoid base 1-pho
Autor:
John A. Petros, Mark Baillie, Jingjing Gao, Taylor J. Evers, Michael G. Natchus, Eric J. Miller, Deborah G. Culver, Richard F. Arrendale, Suzanne G. Mays, G. Prakabahr Reddy, Randy B. Howard, Sarah T. Pruett, Anatoliy S. Bushnev, Dennis C. Liotta
Publikováno v:
Journal of Urology. 189
INTRODUCTION AND OBJECTIVES: Retroviral replicating vectors (RRVs) represent a novel gene delivery platform that can achieve efficient transduction of solid tumors through virus propagation within actively dividing cancer cells. FDA has already appro
Publikováno v:
Chemistry and Physics of Lipids. 82:85-88
The synthesis of racemic 1-deoxy-1-thio-dihydroceramide-1-phosphate 6 from rac -3-benzoyl-dihydroceramide 1 as a substrate analogue for ceramide 1-phosphate phosphatase, was developed using an Arbuzov-type reaction to form the S-P bond.
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:147-151
The synthesis of optically-active hexadecyl thiophosphoryl-1- d -myo-inositol 11 was accomplished from 2,3-O-( d -1′,7′,7′-trimethyl[2.2.1]bicyclohept-2′-ylidene)-4,5,6-O-tris(methoxymethyl)- d -myo-inositol 6 or 2,3,4,5,6-O-pentakis(methoxym
Autor:
Jason J. Holt, Esmeralda V. S. Meyer, Deborah G. Culver, Mark T. Ballie, G. Prabhakar Reddy, Dennis C. Liotta, Kathryn R. Girard, David S. Menaldino, Randy B. Howard, Anatoliy S. Bushnev, Taylor J. Evers, Stacey A. Lapp, Mary R. Galinski, Richard F. Arrendale, Michael G. Natchus
Publikováno v:
ACS medicinal chemistry letters. 3(1)
Plasmodium-infected erythrocytes have been shown to employ sphingolipids from both endogenous metabolism as well as existing host pools. Therapeutic agents that limit these supplies have thus emerged as intriguing, mechanistically distinct putative t