Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anat Iosub-Amir"'
Autor:
Fang Bai, Ola Karmi, Guy Mayer, Yang Sung Sohn, Henri-Baptiste Marjault, José N. Onuchic, Sagi Tamir, Patricia A. Jennings, Assaf Friedler, Rachel Nechushtai, Ron Mittler, Luhua Song, Anat Iosub-Amir
Publikováno v:
Chemical Science
We reveal a novel interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells, and propose that this interaction is required for apoptosis activation in cancer cells. A peptide derived fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4f2c30cfe32cd751417d2a412dae6d
http://europepmc.org/articles/PMC6349067
http://europepmc.org/articles/PMC6349067
Publikováno v:
Encyclopedia of Biophysics ISBN: 9783642359439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295475df32a114772e03898613ed3a04
https://doi.org/10.1007/978-3-642-35943-9_189-1
https://doi.org/10.1007/978-3-642-35943-9_189-1
Autor:
Assaf Friedler, Anat Iosub-Amir
Publikováno v:
Med. Chem. Commun.. 5:1435-1443
The pro-apoptotic ASPP2 protein plays a central role in regulating apoptosis in both p53-dependent and p53-independent pathways. It has become clear in recent years that ASPP2 plays also a role in other important cellular processes like senescence an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::629fafe0e6d921cd78cae94653d99643
https://doi.org/10.1039/c4md00147h
https://doi.org/10.1039/c4md00147h
Autor:
Assaf Friedler, Norman Metanis, Priyadip Das, Anat Iosub-Amir, Samarasimhareddy Mamidi, Koushik Chandra, Mattan Hurevich, Meital Reches
Publikováno v:
ChemMedChem. 11(18)
We present a new approach for the covalent inhibition of HIV-1 integrase (IN) by an LEDGF/p75-derived peptide modified with an N-terminal succinimide group. The covalent inhibition is mediated by direct binding of the succinimide to the amine group o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f50df7a7b690b48bcfe388fba45bdc
https://pubmed.ncbi.nlm.nih.gov/27331774
https://pubmed.ncbi.nlm.nih.gov/27331774
Autor:
Mario Lebendiker, Assaf Friedler, Martijn van Rosmalen, Tsafi Danieli, Guy Mayer, Anat Iosub Amir
Publikováno v:
Scientific Reports
We present a possible molecular basis for the opposite activity of two homologues proteins that bind similar ligands and show that this is achieved by fine-tuning of the interaction interface. The highly homologous ASPP proteins have opposite roles i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3792dc0ba34ec86a30ac13f80b779f72
https://doi.org/10.1038/srep11629
https://doi.org/10.1038/srep11629
Autor:
Anat Iosub-Amir, Assaf Friedler, Daniel A. Bonsor, Hadar Amartely, Eric J. Sundberg, Tali H. Reingewertz, Guy Mayer
Publikováno v:
Biochemistry. 54(21)
The leading risk factor for gastric cancer in humans is infection by Helicobacter pylori strains that express and translocate the oncoprotein CagA into host epithelial cells. Once inside host cells, CagA interacts with ASPP2, which specifically stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb7e8e1e09c9eebf2d0e86f9d99a921
https://pubmed.ncbi.nlm.nih.gov/25963096
https://pubmed.ncbi.nlm.nih.gov/25963096
Publikováno v:
Journal of visualized experiments : JoVE. (93)
Protein-protein interactions mediate most of the processes in the living cell and control homeostasis of the organism. Impaired protein interactions may result in disease, making protein interactions important drug targets. It is thus highly importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021d14dcc79c580a560039ea77ad4be2
https://pubmed.ncbi.nlm.nih.gov/25490271
https://pubmed.ncbi.nlm.nih.gov/25490271
Autor:
Daniel A. Bonsor, Tiffany W. Chen, Tali H. Reingewertz, Eric J. Sundberg, Evelyn Weiss, Anat Iosub-Amir, Assaf Friedler, Rainer Haas, Wolfgang Fischer
CagA is a virulence factor that Helicobacter pylori inject into gastric epithelial cells through a type IV secretion system where it can cause gastric adenocarcinoma. Translocation is dependent on the presence of secretion signals found in both the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b90000496abe3810f0e9055e42f56d2
https://europepmc.org/articles/PMC3829141/
https://europepmc.org/articles/PMC3829141/
Autor:
Meital Reches, Priyadip Das, Samarasimhareddy Mamidi, Mattan Hurevich, Assaf Friedler, Koushik Chandra, Anat Iosub-Amir, Norman Metanis
Publikováno v:
ChemMedChem. 11:1969-1969
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5723388e67936a5ff6d118feefdd726a
https://doi.org/10.1002/cmdc.201600435
https://doi.org/10.1002/cmdc.201600435