Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Anat Bashan"'
Autor:
K. Shanmugha Rajan, Saurav Aryal, Disha-Gajanan Hiregange, Anat Bashan, Hava Madmoni, Mika Olami, Tirza Doniger, Smadar Cohen-Chalamish, Pascal Pescher, Masato Taoka, Yuko Nobe, Aliza Fedorenko, Tanaya Bose, Ella Zimermann, Eric Prina, Noa Aharon-Hefetz, Yitzhak Pilpel, Toshiaki Isobe, Ron Unger, Gerald F. Späth, Ada Yonath, Shulamit Michaeli
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114203- (2024)
Summary: Leishmania is the causative agent of cutaneous and visceral diseases affecting millions of individuals worldwide. Pseudouridine (Ψ), the most abundant modification on rRNA, changes during the parasite life cycle. Alterations in the level of
Externí odkaz:
https://doaj.org/article/1af39d1e364149228194dd16b1cc4963
Autor:
K. Shanmugha Rajan, Hava Madmoni, Anat Bashan, Masato Taoka, Saurav Aryal, Yuko Nobe, Tirza Doniger, Beathrice Galili Kostin, Amit Blumberg, Smadar Cohen-Chalamish, Schraga Schwartz, Andre Rivalta, Ella Zimmerman, Ron Unger, Toshiaki Isobe, Ada Yonath, Shulamit Michaeli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Trypanosomes are protozoan parasites that cycle between insect and mammalian hosts and are the causative agent of sleeping sickness. Here, we describe the changes of pseudouridine (Ψ) modification on rRNA in the two life stages of the paras
Externí odkaz:
https://doaj.org/article/13fe9a6c17164bf5b6d6496ccbcea44a
Autor:
Disha‐Gajanan Hiregange, Andre Rivalta, Ada Yonath, Ella Zimmerman, Anat Bashan, Hagith Yonath
Publikováno v:
FEBS Open Bio, Vol 12, Iss 7, Pp 1419-1434 (2022)
Ribosomes, the cellular organelles translating the genetic code to proteins, are assemblies of RNA chains and many proteins (RPs) arranged in precise fine‐tuned interwoven structures. Mutated ribosomal genes cause ribosomopathies, including Diamond
Externí odkaz:
https://doaj.org/article/0ce63b00562444fdb43438c0573327c8
Autor:
Anh Minh Thao Nguyen, Moran Shalev-Benami, Chloé Rosa-Teijeiro, Ana Victoria Ibarra-Meneses, Ada Yonath, Anat Bashan, Charles L. Jaffe, Martin Olivier, Christopher Fernandez-Prada, William D. Lubell
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2541 (2023)
Assessment of structure–activity relationships for anti-protozoan activity revealed a strategy for preparing potent anisomycin derivatives with reduced host toxicity. Thirteen anisomycin analogs were synthesized by modifying the alcohol, amine, and
Externí odkaz:
https://doaj.org/article/321140252ace494dbd001f5473b641f1
Autor:
Giuseppe Cimicata, Gil Fridkin, Tanaya Bose, Zohar Eyal, Yehuda Halfon, Elinor Breiner-Goldstein, Tara Fox, Ella Zimmerman, Anat Bashan, Natalia de Val, Alexander Wlodawer, Ada Yonath
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The ribosome, a multicomponent assembly consisting of RNA and proteins, is a pivotal macromolecular machine that translates the genetic code into proteins. The large ribosomal subunit rRNA helix 68 (H68) is a key element in the protein synth
Externí odkaz:
https://doaj.org/article/d0fed25417f0439887632ec8537d4997
Autor:
Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highligh
Externí odkaz:
https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d88
Autor:
Donna Matzov, Shintaro Aibara, Arnab Basu, Ella Zimmerman, Anat Bashan, Mee-Ngan F. Yap, Alexey Amunts, Ada E. Yonath
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Under conditions of nutrient limitation, bacterial ribosomes undergo dimerization, forming a 100S complex that is translationally inactive. Here the authors present the structural basis for formation of the 100S complexes in Gram-positive bacteria, s
Externí odkaz:
https://doaj.org/article/5462b5389ea14028988762da9a1a55f4
Autor:
Moran Shalev-Benami, Yan Zhang, Donna Matzov, Yehuda Halfon, Arie Zackay, Haim Rozenberg, Ella Zimmerman, Anat Bashan, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 288-294 (2016)
Leishmania is a single-cell eukaryotic parasite of the Trypanosomatidae family, whose members cause an array of tropical diseases. The often fatal outcome of infections, lack of effective vaccines, limited selection of therapeutic drugs, and emerging
Externí odkaz:
https://doaj.org/article/6b7985b7448545f39a7420e4af650987
Autor:
Matthew J. Belousoff, Zohar Eyal, Mazdak Radjainia, Tofayel Ahmed, Rebecca S. Bamert, Donna Matzov, Anat Bashan, Ella Zimmerman, Satabdi Mishra, David Cameron, Hans Elmlund, Anton Y. Peleg, Shashi Bhushan, Trevor Lithgow, Ada Yonath
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural informati
Externí odkaz:
https://doaj.org/article/1ec9f31a43344b03be4992f9b65c601b
Autor:
Tamar Auerbach-Nevo, David Baram, Anat Bashan, Matthew Belousoff, Elinor Breiner, Chen Davidovich, Giuseppe Cimicata, Zohar Eyal, Yehuda Halfon, Miri Krupkin, Donna Matzov, Markus Metz, Mruwat Rufayda, Moshe Peretz, Ophir Pick, Erez Pyetan, Haim Rozenberg, Moran Shalev-Benami, Itai Wekselman, Raz Zarivach, Ella Zimmerman, Nofar Assis, Joel Bloch, Hadar Israeli, Rinat Kalaora, Lisha Lim, Ofir Sade-Falk, Tal Shapira, Leena Taha-Salaime, Hua Tang, Ada Yonath
Publikováno v:
Antibiotics, Vol 5, Iss 3, p 24 (2016)
Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation. Owing to the global rapid increase in the appearance
Externí odkaz:
https://doaj.org/article/38f282b678d544b195b47abf37f54af3