Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anasua Bose"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101884 (2014)
Drosophila Enhancer of split M8, an effector of Notch signaling, is regulated by protein kinase CK2. The phosphatase PP2A is thought to play an opposing (inhibitory) role, but the identity of the regulatory subunit was unknown. The studies described
Externí odkaz:
https://doaj.org/article/62e1dfe44f504bc4b14087407bbf4ed7
Publikováno v:
genesis. 47:647-658
Repression by E(spl)M8 during inhibitory Notch (N) signaling (lateral inhibition) is regulated, in part, by protein kinase CK2, but the involvement of a phosphatase has been unclear. The studies we report here employ Tik, a unique dominant-negative (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cfba6c5bb80d8db7191716bc234f03
https://doi.org/10.1002/dvg.20543
https://doi.org/10.1002/dvg.20543
Autor:
Sophia Zhang, Bhaskar Kahali, Jui Ming Lin, Umesh C. Karandikar, Anasua Bose, Ashok P. Bidwai, Ravi Allada
Publikováno v:
Mechanisms of Development. 123:649-664
Lateral inhibition is critical for cell fate determination and involves the functions of Notch (N) and its effectors, the Enhancer of Split Complex, E(spl)C repressors. Although E(spl) proteins mediate the repressive effects of N in diverse contexts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8e7eaae24685d5e9fe8d2bdaf9cb74
https://doi.org/10.1016/j.mod.2006.07.003
https://doi.org/10.1016/j.mod.2006.07.003
On the mechanism underlying the divergent retinal and bristle defects of M8* (E(spl)D) in Drosophila
Our results, using endogenous mutants and Gal4-UAS driven transgenes, implicate multisite phosphorylation in repression by E(spl)M8. We propose that these phosphorylations occur in the morphogenetic furrow (MF) to reverse an auto-inhibited state of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71f60826abf0a0aac4e4e334c6e4e4d
https://europepmc.org/articles/PMC2777619/
https://europepmc.org/articles/PMC2777619/
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e101884 (2014)
PLoS ONE, Vol 9, Iss 7, p e101884 (2014)
Drosophila Enhancer of split M8, an effector of Notch signaling, is regulated by protein kinase CK2. The phosphatase PP2A is thought to play an opposing (inhibitory) role, but the identity of the regulatory subunit was unknown. The studies described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c807fd4498d0277b1ce5785c9ee3c2b0
https://doi.org/10.1371/journal.pone.0101884
https://doi.org/10.1371/journal.pone.0101884