Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors.

Autor: Franck Talmont, Lionel Moulédous, Marion Baranger, Anne Gomez-Brouchet, Jean-Marie Zajac, Clarence Deffaud, Olivier Cuvillier, Anastassia Hatzoglou

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213203 (2019)

Although sphingosine-1-phosphate receptor 1 (S1P1) has been shown to trigger several S1P targeted functions such as immune cell trafficking, cell proliferation, migration, or angiogenesis, tools that allow the accurate detection of endogenous S1P1 lo

Externí odkaz: https://doaj.org/article/355e0b4b199342beabc3caffc370d43a

[Multiple sclerosis and immuno-modulators of sphingosine 1-phosphate receptors]

Autor: Franck, Talmont, Anastassia, Hatzoglou, Olivier, Cuvillier

Publikováno v: Medecine sciences : M/S. 36(3)

Multiple sclerosis (MS) is a disease of the central nervous system with a very debilitating inflammatory component that usually affects young people (years 20-40). This disease is characterized by the progressive destruction of the myelin sheath of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::607af79afdb312854bc1b4a7cb250618
https://pubmed.ncbi.nlm.nih.gov/32228843

p27Kip1 regulates the microtubule bundling activity of PRC1

Autor: Renaud T. Perchey, Murielle P. Serres, Ada Nowosad, Justine Creff, Caroline Callot, Alexandre Gay, Stéphane Manenti, Robert L. Margolis, Anastassia Hatzoglou, Arnaud Besson

Publikováno v: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2018, 1865 (11), pp.1630-1639. ⟨10.1016/j.bbamcr.2018.08.010⟩
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2018, 1865 (11), pp.1630-1639. ⟨10.1016/j.bbamcr.2018.08.010⟩

International audience; Cytokinesis begins in anaphase with the formation of the central spindle. PRC1 is a microtubule associated protein that plays an essential role in central spindle formation by crosslinking antiparallel microtubules. We have id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307cb1055912caf0bbedee5c37cab2ae
https://doi.org/10.1016/j.bbamcr.2018.08.010

Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors

Autor: Marion Baranger, Franck Talmont, Anne Gomez-Brouchet, Jean-Marie Zajac, Clarence Deffaud, Olivier Cuvillier, Lionel Moulédous, Anastassia Hatzoglou

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (3), pp.e0213203. ⟨10.1371/journal.pone.0213203⟩
PLoS ONE, Vol 14, Iss 3, p e0213203 (2019)

International audience; Although sphingosine-1-phosphate receptor 1 (S1P1) has been shown to trigger several S1P targeted functions such as immune cell trafficking, cell proliferation, migration, or angiogenesis, tools that allow the accurate detecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d8b36b8b32408c49f376c0317500a1
https://hal.archives-ouvertes.fr/hal-02351986

Sphingosine 1-phosphate signaling through its receptor S1P

Autor: Guillaume, Andrieu, Adeline, Ledoux, Sophie, Branka, Magalie, Bocquet, Julia, Gilhodes, Thierry, Walzer, Kousuke, Kasahara, Masaki, Inagaki, Roger A, Sabbadini, Olivier, Cuvillier, Anastassia, Hatzoglou

Publikováno v: Science signaling. 10(472)

Sphingosine kinase 1 (SphK1) promotes cell proliferation and survival, and its abundance is often increased in tumors. SphK1 produces the signaling lipid sphingosine 1-phosphate (S1P), which activates signaling cascades downstream five G protein-coup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9341c6fab6ac27952834ab3970e9eb0
https://pubmed.ncbi.nlm.nih.gov/28351953