Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Anastasiya Hladik"'
Autor:
Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier
Publikováno v:
eLife, Vol 13 (2024)
FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in T cells, effector Treg cell frequencies were elev
Externí odkaz:
https://doaj.org/article/99b838b47ea54f90b5aa68be8607b3a8
Autor:
Riem Gawish, Barbara Maier, Georg Obermayer, Martin L Watzenboeck, Anna-Dorothea Gorki, Federica Quattrone, Asma Farhat, Karin Lakovits, Anastasiya Hladik, Ana Korosec, Arman Alimohammadi, Ildiko Mesteri, Felicitas Oberndorfer, Fiona Oakley, John Brain, Louis Boon, Irene Lang, Christoph J Binder, Sylvia Knapp
Publikováno v:
eLife, Vol 11 (2022)
Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options to prevent sepsis-associated immunopathology remain scarce. Here, we established a mouse mo
Externí odkaz:
https://doaj.org/article/488b92e3c6ae4a14a465997f8ae7c7c0
Autor:
Robert H Shoemaker, Reynold A Panettieri, Steven K Libutti, Howard S Hochster, Norman R Watts, Paul T Wingfield, Philipp Starkl, Lisabeth Pimenov, Riem Gawish, Anastasiya Hladik, Sylvia Knapp, Daniel Boring, Jonathan M White, Quentin Lawrence, Jeremy Boone, Jason D Marshall, Rebecca L Matthews, Brian D Cholewa, Jeffrey W Richig, Ben T Chen, David L McCormick, Romana Gugensberger, Sonja Höller, Josef M Penninger, Gerald Wirnsberger
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271066 (2022)
As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung dama
Externí odkaz:
https://doaj.org/article/de12786ecde24914a9f12e92f2296a6a
Autor:
Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik, Karin Lakovits, Felicitas Oberndorfer, Shane JF Cronin, Anna Ohradanova-Repic, Gerald Wirnsberger, Benedikt Agerer, Lukas Endler, Tümay Capraz, Jan W Perthold, Domagoj Cikes, Rubina Koglgruber, Astrid Hagelkruys, Nuria Montserrat, Ali Mirazimi, Louis Boon, Hannes Stockinger, Andreas Bergthaler, Chris Oostenbrink, Josef M Penninger, Sylvia Knapp
Publikováno v:
eLife, Vol 11 (2022)
Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modelin
Externí odkaz:
https://doaj.org/article/c49137ed8a364fa0b46437d84e5c0342
Autor:
Lisa Sandner, Marlis Alteneder, Ci Zhu, Anastasiya Hladik, Sandra Högler, Ramona Rica, Lars W. Van Greuningen, Omar Sharif, Shinya Sakaguchi, Sylvia Knapp, Lukas Kenner, Michael Trauner, Wilfried Ellmeier, Nicole Boucheron
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T helper (Th) 17 cells are not only key in controlling infections mediated by extracellular bacteria and fungi but are also triggering autoimmune responses. Th17 cells comprise heterogeneous subsets, some with pathogenic functions. They can cease to
Externí odkaz:
https://doaj.org/article/1b5beb14571242fe9834605e9ba8f982
Autor:
Martin L Watzenboeck, Barbara Drobits, Sophie Zahalka, Anna-Dorothea Gorki, Asma Farhat, Federica Quattrone, Anastasiya Hladik, Karin Lakovits, Gabriel M Richard, Therese Lederer, Birgit Strobl, Gijs A Versteeg, Louis Boon, Philipp Starkl, Sylvia Knapp
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009487 (2021)
Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron uptake and exerts immunomodulatory functions in various diseases. Here, we aimed to characte
Externí odkaz:
https://doaj.org/article/350841de659e460bb7aad2175ab5017b
Autor:
Daniela Hainberger, Valentina Stolz, Ci Zhu, Michael Schuster, Lena Müller, Patricia Hamminger, Ramona Rica, Darina Waltenberger, Marlis Alteneder, Thomas Krausgruber, Anastasiya Hladik, Sylvia Knapp, Christoph Bock, Michael Trauner, Michael A. Farrar, Wilfried Ellmeier
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific
Externí odkaz:
https://doaj.org/article/86713e0c5dfb4380b6c7acd6ce06b46a
Autor:
Liisa Andersen, Alexandra Franziska Gülich, Marlis Alteneder, Teresa Preglej, Maria Jonah Orola, Narendra Dhele, Valentina Stolz, Alexandra Schebesta, Patricia Hamminger, Anastasiya Hladik, Stefan Floess, Thomas Krausgruber, Thomas Faux, Syed Bilal Ahmad Andrabi, Jochen Huehn, Sylvia Knapp, Tim Sparwasser, Christoph Bock, Asta Laiho, Laura L. Elo, Omid Rasool, Riitta Lahesmaa, Shinya Sakaguchi, Wilfried Ellmeier
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4447-4459.e6 (2019)
Summary: Forkhead box protein P3+ (FOXP3+) regulatory T cells (Treg cells) play a key role in maintaining tolerance and immune homeostasis. Here, we report that a T cell-specific deletion of the transcription factor MAZR (also known as PATZ1) leads t
Externí odkaz:
https://doaj.org/article/974129bdad3742e980b60d2cd2ed4c8c
Autor:
Simona Saluzzo, Anna-Dorothea Gorki, Batika M.J. Rana, Rui Martins, Seth Scanlon, Philipp Starkl, Karin Lakovits, Anastasiya Hladik, Ana Korosec, Omar Sharif, Joanna M. Warszawska, Helen Jolin, Ildiko Mesteri, Andrew N.J. McKenzie, Sylvia Knapp
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1893-1905 (2017)
From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and infection. We investigated the homeostatic role of the epithelium-derived alarmin interleuk
Externí odkaz:
https://doaj.org/article/76d80441ccf44df28f1875171ed486cd
Autor:
Jana Prochazkova, Shinya Sakaguchi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Georgia Velimezi, Martin Moder, Gleb Turchinovich, Anastasiya Hladik, Elisabeth Gurnhofer, Adrian Hayday, Axel Behrens, Sylvia Knapp, Lukas Kenner, Wilfried Ellmeier, Joanna I Loizou
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005645 (2015)
Proper development of the immune system is an intricate process dependent on many factors, including an intact DNA damage response. The DNA double-strand break signaling kinase ATM and its cofactor NBS1 are required during T cell development and for
Externí odkaz:
https://doaj.org/article/4c7d8a5dd938454eb59061facd4d75d6