Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anastasiya, Börsch"'
Autor:
Alfred Zippelius, Mélanie Buchi, Petra Herzig, Heinz Läubli, Kirsten D Mertz, Viola Heinzelmann-Schwarz, Didier Lardinois, Marina Natoli, Clara Serger, Alberto Toso, Nicole Brodmann, Sofia Tundo, Marcel Trefny, Andrijana Rodić, Olivia Grueninger, Anastasiya Börsch, Jonas Fürst, Katarzyna Buczak, Alex T Müller, Lisa Sach-Peltason, Leyla Don, Aljaž Hojski, Karin Schaeuble, Thuy T Luu, Andrea Romagnani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background T cell-based immunotherapies including immune checkpoint blockade and chimeric antigen receptor T cells can induce durable responses in patients with cancer. However, clinical efficacy is limited due to the ability of cancer cells to evade
Externí odkaz:
https://doaj.org/article/0bded18942fa48e2a0fc5413e4d9249a
Autor:
Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114807- (2024)
Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,
Externí odkaz:
https://doaj.org/article/3f4435c1df914aa5bdc0b2931130faf7
Autor:
Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heteroge
Externí odkaz:
https://doaj.org/article/58106d4dcccf4fdebf3a90d5d836fcdb
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtman, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. Here the authors show that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.
Externí odkaz:
https://doaj.org/article/444da6d136f045099a95445e8d650a04
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background The behavior of cells in vivo is complex and highly dynamic, as it results from an interplay between intercellular matrix proteins with surface receptors and other microenvironmental cues. Although the effects of the cellular nich
Externí odkaz:
https://doaj.org/article/20f3b66fa17442bd9980e2641c23695b
Autor:
Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent mode
Externí odkaz:
https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a
Autor:
Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition pres
Externí odkaz:
https://doaj.org/article/05a591c692df4b149c92e816d5905072
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtmann, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c879cf0cbe364394806d8ecf246c6dbb
Autor:
Souvik, Ghosh, Meric, Ataman, Maciej, Bak, Anastasiya, Börsch, Alexander, Schmidt, Katarzyna, Buczak, Georges, Martin, Beatrice, Dimitriades, Christina J, Herrmann, Alexander, Kanitz, Mihaela, Zavolan
Publikováno v:
Nucleic acids research. 50(6)
The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation (APA) in a broad range of contexts, from cancers to learning deficits and parasite infections. To determine how the CFIm expression levels are translated into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa2791b36dde27711572358e33afb612
https://pubmed.ncbi.nlm.nih.gov/35234914
https://pubmed.ncbi.nlm.nih.gov/35234914
Autor:
Ronja Wieboldt, Andreas Zingg, Emanuele Carlini, Anastasiya Börsch, Heinz Läubli, Natalia Rodrigues Manutano
Publikováno v:
Cancer Research. 83:1259-1259
Background: Overexpression of sialic acids on glycans, called hypersialylation is a common alteration in cancer that drives immune evasion via interaction with Sialic acid-binding immunoglobulin-like lectin (Siglec) immunoregulatory receptors on tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f57c16fc1cf16ef9d51a0e5f68883c9e
https://doi.org/10.1158/1538-7445.am2023-1259
https://doi.org/10.1158/1538-7445.am2023-1259