TSG‐6 Is Weakly Chondroprotective in Murine OA but Does not Account for FGF2‐Mediated Joint Protection

Autor: Linyi Zhu, Shannah Donhou, Annika Burleigh, Jadwiga Miotla Zarebska, Marcia Curtinha, Ida Parisi, Sumayya Nafisa Khan, Francesco Dell’Accio, Anastasios Chanalaris, Tonia L. Vincent

Publikováno v: ACR Open Rheumatology, Vol 2, Iss 10, Pp 605-615 (2020)

Objective Tumor necrosis factor α–stimulated gene 6 (TSG‐6) is an anti‐inflammatory protein highly expressed in osteoarthritis (OA), but its influence on the course of OA is unknown. Methods Cartilage injury was assessed by murine hip avulsion

Externí odkaz: https://doaj.org/article/e77822038b8847f581cb6871c9779453

Variants in

Autor: Linyi, Zhu, Pragash, Kamalathevan, Lada A, Koneva, Jadwiga Miotla, Zarebska, Anastasios, Chanalaris, Heba, Ismail, Akira, Wiberg, Michael, Ng, Hayat, Muhammad, John, Walsby-Tickle, James S O, McCullagh, Fiona E, Watt, Stephen N, Sansom, Dominic, Furniss, Matthew D, Gardiner, Tonia L, Vincent, Nick, Riley, Michelle, Spiteri, Ian, McNab, Christopher, Little, Lucy, Cogswell, Paul, Critchley, Henk, Giele, Rebecca, Shirley

Publikováno v: Science translational medicine. 14(676)

More than 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease-modifying treatments for this disabling condition. Common polymorphic variants in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff4aa8edfb7848f53f8df8ff6d29435d
https://pubmed.ncbi.nlm.nih.gov/36542696

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage

Autor: C.Y. Yang, O. McClurg, Hideaki Nagase, Linda Troeberg, Mark L. Day, Angelica L. Cates, Anastasios Chanalaris, Stephan A. Müller, Tonia L. Vincent, Simone D. Scilabra, Simone Bonelli, J. Miotla Zarebska, G. Lorenzatti Hiles, Stefan F. Lichtenthaler

Publikováno v: Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100128-(2020)
Osteoarthritis and Cartilage Open
Osteoarthritis and cartilage 2(4), 100128 (2020). doi:10.1016/j.ocarto.2020.100128

Objective The adamalysin metalloproteinase 15 (ADAM15) has been shown to protect against development of osteoarthritis in mice. Here, we have investigated factors that control ADAM15 levels in cartilage. Design Secretomes from wild-type and Adam15−

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d631b78e466060f993c6b59d8211cb75
http://www.sciencedirect.com/science/article/pii/S266591312030128X

Heparan sulfate proteoglycan synthesis is dysregulated in human osteoarthritic cartilage

Autor: Hannah Clarke, Anastasios Chanalaris, Linda Troeberg, Scott E. Guimond, Jeremy E. Turnbull, Tonia L. Vincent

Publikováno v: The American journal of pathology

Osteoarthritis (OA) is a common degenerative joint disease, characterized by cartilage loss and subchondral bone remodeling in response to abnormal mechanical load. Heparan sulfate (HS) proteoglycans bind to many proteins that regulate cartilage home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd6e430cf34739672e00cd1cd28fb3d
http://ora.ox.ac.uk/objects/uuid:

OP0261 Retinoic acid is regulated by cartilage injury and is anti-inflammatory in hand osteoarthritis

Autor: Linyi Zhu, Matthew D Gardiner, H M Ismail, Tonia L. Vincent, Anastasios Chanalaris

Publikováno v: FRIDAY, 15 JUNE 2018.

Background A Genome-Wide Association Study (GWAS) in hand OA has identified the association of hypomorphic variants within ALDH1A2 and severe hand OA (Styrkarsdottir U, et al. 2014). This gene encodes the enzyme catalysing the production of all-trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51d79089719740d09e01d2815fda7446
https://doi.org/10.1136/annrheumdis-2018-eular.3647