Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Anastasiia Gusach"'
Autor:
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J. Koers, Qingchao Chen, Patricia C. Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B. Veprintsev, Nagarajan Vaidehi, Simone N. Weyand, Christopher G. Tate
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar
Externí odkaz:
https://doaj.org/article/652fff5f256d4ddc952071804619e0c2
Autor:
Ivan Maslov, Oleksandr Volkov, Polina Khorn, Philipp Orekhov, Anastasiia Gusach, Pavel Kuzmichev, Andrey Gerasimov, Aleksandra Luginina, Quinten Coucke, Andrey Bogorodskiy, Valentin Gordeliy, Simon Wanninger, Anders Barth, Alexey Mishin, Johan Hofkens, Vadim Cherezov, Thomas Gensch, Jelle Hendrix, Valentin Borshchevskiy
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Single-molecule FRET experiments with human A2A adenosine receptor in its apo and agonist-bound states in lipid nanodiscs provide insights into its conformational dynamics and activation.
Externí odkaz:
https://doaj.org/article/c12033b931e0417fb3fa4f01210d924a
Autor:
Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and sh
Externí odkaz:
https://doaj.org/article/36cf9a61df10484aabf068185a39d283
Autor:
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonis
Externí odkaz:
https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c7
Autor:
Egor Marin, Daniil Vakhrameev, Anastasiia Gusach, Aleksandra Luginina, Kirill Kovalev, Wei Liu, Uwe Weierstall, Jaehun Park, Ki Hyun Nam, Cho Yunje, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 12-12 (2021)
Background: Membrane receptors play an important role in signal transduction across the cell membrane in all living organisms. Their structural studies have been enabled by multiple technological breakthroughs in their heterologous expression, stabil
Externí odkaz:
https://doaj.org/article/841a90d82024427a84f205a4f2d94f81
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S18-S18 (2019)
Background: Seven helical transmembrane G-protein coupled receptors (GPCRs) involved in various extracellular ligand recognition and signal transduction processes are prominent targets of about a third of existing drugs (Sriram and Insel, 2018). The
Externí odkaz:
https://doaj.org/article/78fd1da6339c4d16939e68fa7f93d11d
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S19-S19 (2019)
Background: G-protein coupled receptors (GPCR) are drug targets of great current interest, being meanwhile a challenging object for structural research. Methods and Results: The protein of interest needs to be expressed in necessary amounts. To obta
Externí odkaz:
https://doaj.org/article/35fa9fb2895047108d4e9b6885ea55ea
Autor:
Arman A. Sadybekov, Rebecca L. Brouillette, Egor Marin, Anastasiia V. Sadybekov, Aleksandra Luginina, Anastasiia Gusach, Alexey Mishin, Élie Besserer-Offroy, Jean-Michel Longpré, Valentin Borshchevskiy, Vadim Cherezov, Philippe Sarret, Vsevolod Katritch
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1634 (2020)
Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely use
Externí odkaz:
https://doaj.org/article/f10a2b76089f4d51a6bf3e664058debc
Autor:
Egor Marin, Aleksandra Luginina, Anastasiia Gusach, Kirill Kovalev, Sergey Bukhdruker, Polina Khorn, Vitaly Polovinkin, Elizaveta Lyapina, Andrey Rogachev, Valentin Gordeliy, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy
Publikováno v:
Scientific Data, Vol 7, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759-w
Externí odkaz:
https://doaj.org/article/2cc6e5f2b9104fa693fb6ef368ca0642
Autor:
Sergey Bukhdruker, Tatsiana Varaksa, Irina Grabovec, Egor Marin, Polina Shabunya, Maria Kadukova, Sergei Grudinin, Anton Kavaleuski, Anastasiia Gusach, Andrei Gilep, Valentin Borshchevskiy, Natallia Strushkevich
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7683 (2020)
Spreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III c
Externí odkaz:
https://doaj.org/article/9fced5ea79184d17bb63e5ddd4b8d716