Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anastasiia, Sadybekov"'
Autor:
Sadhna Rao, Anastasiia Sadybekov, David C. DeWitt, Joanna Lipka, Vsevolod Katritch, Bruce E. Herring
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Glutamatergic synapse dysfunction is believed to underlie the development of Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) in many individuals. However, identification of genetic markers that contribute to synapt
Externí odkaz:
https://doaj.org/article/e04f25582550489b9b9369030d6873fe
Autor:
Yuni Kay, Linda Tsan, Elizabeth A. Davis, Chen Tian, Léa Décarie-Spain, Anastasiia Sadybekov, Anna N. Pushkin, Vsevolod Katritch, Scott E. Kanoski, Bruce E. Herring
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The effects of SAP97 mutations associated with schizophrenia on synaptic function are unclear. Here, the authors show that schizophrenia-related SAP97 mutations enhance glutamatergic synapse strength in the dentate gyrus, impairing contextual episodi
Externí odkaz:
https://doaj.org/article/34321e5d4b324a028991853b3ee86f90
Autor:
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A. Zamlynny, Xavier Fradera, Phieng Siliphaivanh, Jeremy Presland, Kerrie B. Spencer, Stephen M. Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective ant
Externí odkaz:
https://doaj.org/article/718b186632fa46f2ad43c9c7ad152fa9
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Trio is a RhoGEF protein that promotes actin polymerization and is implicated in the regulation of glutamatergic synapses in autism spectrum disorder (ASD). Here the authors identify a large cluster of de novo mutations in the GEF1 domain of Trio in
Externí odkaz:
https://doaj.org/article/702daf542acd4526850de52f756d5ee1
Autor:
Chongzhe Yang, Jie Li, Zhiyong Deng, Songyuan Luo, Jing Liu, Wenqian Fang, Feng Liu, Tianxiao Liu, Xian Zhang, Yuanyuan Zhang, Zhaojie Meng, Shuya Zhang, Jianfang Luo, Conglin Liu, Dafeng Yang, Lijun Liu, Galina K Sukhova, Anastasiia Sadybekov, Vsevolod Katritch, Peter Libby, Jing Wang, Junli Guo, Guo-Ping Shi
Publikováno v:
Cardiovascular Research. 119:195-212
Aims Blood eosinophil (EOS) counts and EOS cationic protein (ECP) levels associate positively with major cardiovascular disease (CVD) risk factors and prevalence. This study investigates the role of EOS in cardiac hypertrophy. Methods and results A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db6445ff90a01f0df72d8d09820a6b2
https://doi.org/10.1093/cvr/cvac060
https://doi.org/10.1093/cvr/cvac060
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The small GTPase Rac1 promotes actin polymerization and plays a critical and increasingly appreciated role in the development and plasticity of glutamatergic synapses. Growing evidence suggests that disruption of the Rac1 signaling pathway at glutama
Externí odkaz:
https://doaj.org/article/c9804fdaa16f4f1aac24d6ffc0def608
Autor:
Jordan Eboreime, Soo‐Kyung Choi, Song‐Ro Yoon, Anastasiia Sadybekov, Vsevolod Katritch, Peter Calabrese, Norman Arnheim
Publikováno v:
Human mutationREFERENCES. 43(12)
Some spontaneous germline gain-of-function mutations promote spermatogonial stem cell clonal expansion and disproportionate variant sperm production leading to unexpectedly high transmission rates for some human genetic conditions. To measure the fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f1e478ed65103a502267d86747eb65
https://pubmed.ncbi.nlm.nih.gov/36349709
https://pubmed.ncbi.nlm.nih.gov/36349709
Autor:
Patrick Pfaff, Anastasiia Sadybekov, James A. Frank, Erick M. Carreira, Roman C. Sarott, Gabriela Rajic, Alexander E. G. Viray, Vsevolod Katritch
Publikováno v:
Journal of the American Chemical Society. 143:736-743
Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation and other diseases. However, a lack of understanding of its complex signaling in cells and tissues complicates the therapeutic exploitation of CB2 as a drug tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8a05b7ad7e2f4608f36f1ce2375b07
https://doi.org/10.1021/jacs.0c08926
https://doi.org/10.1021/jacs.0c08926
Autor:
Vadim Cherezov, Gye Won Han, Anastasiia Sadybekov, Nairie Michaelian, Stephen M. Soisson, Jeremy Presland, Élie Besserer-Offroy, Xavier Fradera, Philippe Sarret, Vsevolod Katritch, Kerrie Spencer, Phieng Siliphaivanh, Beata Zamlynny, Petr Popov, Harini Krishnamurthy
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The leukotriene B4 receptor 1 (BLT1) regulates the recruitment and chemotaxis of different cell types and plays a role in the pathophysiology of infectious, allergic, metabolic, and tumorigenic human diseases. Here we present a crystal structure of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c080e39f8359786e4e005b21dc0196ba
http://europepmc.org/articles/PMC8137929
http://europepmc.org/articles/PMC8137929
Autor:
Roman C, Sarott, Alexander E G, Viray, Patrick, Pfaff, Anastasiia, Sadybekov, Gabriela, Rajic, Vsevolod, Katritch, Erick M, Carreira, James A, Frank
Publikováno v:
Journal of the American Chemical Society. 143(2)
Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation and other diseases. However, a lack of understanding of its complex signaling in cells and tissues complicates the therapeutic exploitation of CB2 as a drug tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9842c03ecc518a82b12639c2d3586914
https://pubmed.ncbi.nlm.nih.gov/33399457
https://pubmed.ncbi.nlm.nih.gov/33399457