Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anastasia Strizhakova"'
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Retinal pigment epithelium (RPE) plays an important role in diabetic retinopathy (DR) progression. Here, the authors show AKT1 and AKT2 are reciprocally regulated in the RPE of DR donor tissue and diabetic mice, reducing Akt2 in RPE causing a compens
Externí odkaz:
https://doaj.org/article/b6a04d515080449b8de555a71e4835ba
Autor:
Haitao Liu, Sayan Ghosh, Tanuja Vaidya, Sridhar Bammidi, Chao Huang, Peng Shang, Archana Padmanabhan Nair, Olivia Chowdhury, Nadezda A. Stepicheva, Anastasia Strizhakova, Stacey Hose, Nikolaos Mitrousis, Santosh Gopikrishna Gadde, Thirumalesh MB, Pamela Strassburger, Gabriella Widmer, Eleonora M. Lad, Patrice E. Fort, José-Alain Sahel, J. Samuel Zigler Jr., Swaminathan Sethu, Peter D. Westenskow, Alan D. Proia, Akrit Sodhi, Arkasubhra Ghosh, Derrick Feenstra, Debasish Sinha
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR
Externí odkaz:
https://doaj.org/article/b18fbfa1ae7541e5a0a6f27bd00d5aed
Autor:
Peng Shang, Nadezda Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting, Stacey Hose, Rhonda Grebe, Meysam Yazdankhah, Sayan Ghosh, Haitao Liu, Anastasia Strizhakova, Joseph Weiss, Imran A. Bhutto, Gerard A. Lutty, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, J. Samuel Zigler, James T. Handa, Yuri Sergeev, Raju V. S. Rajala, Simon Watkins, Debasish Sinha
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin netwo
Externí odkaz:
https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f
Autor:
Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J. Samuel Zigler, Matthew Campbell, Debasish Sinha, James T. Handa, Kai Kaarniranta, Jiang Qian, Sayan Ghosh
Publikováno v:
Cells, Vol 11, Iss 22, p 3535 (2022)
In dry age-related macular degeneration (AMD), inflammation plays a key role in disease pathogenesis. Innate immune cells such as microglia and neutrophils infiltrate the sub-retinal space (SRS) to induce chronic inflammation and AMD progression. But
Externí odkaz:
https://doaj.org/article/e935b45e0c5b43df9923f2f30627a86b
Autor:
Peng Shang, Nadezda A. Stepicheva, Haitao Liu, Olivia Chowdhury, Jonathan Franks, Ming Sun, Stacey Hose, Sayan Ghosh, Meysam Yazdankhah, Anastasia Strizhakova, Donna Beer Stolz, J. Samuel Zigler, Debasish Sinha
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11979 (2021)
Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties ar
Externí odkaz:
https://doaj.org/article/fdcc07a5c43e4d50967ebb8968f7dac1
Autor:
Urvi Gupta, Sayan Ghosh, Callen T. Wallace, Peng Shang, Ying Xin, Archana Padmanabhan Nair, Meysam Yazdankhah, Anastasia Strizhakova, Mark A. Ross, Haitao Liu, Stacey Hose, Nadezda A. Stepicheva, Olivia Chowdhury, Mihir Nemani, Vishnu Maddipatla, Rhonda Grebe, Manjula Das, Kira L. Lathrop, José-Alain Sahel, J. Samuel Zigler, Jiang Qian, Arkasubhra Ghosh, Yuri Sergeev, James T. Handa, Claudette M. St. Croix, Debasish Sinha
Publikováno v:
Autophagy
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 regulates ma
Autor:
Stacey Hose, Haitao Liu, Debasish Sinha, Donna B. Stolz, Ming Sun, Peng Shang, Nadezda A. Stepicheva, Olivia Chowdhury, Meysam Yazdankhah, Anastasia Strizhakova, Sayan Ghosh, Jonathan Franks, J. Samuel Zigler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11979, p 11979 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties ar
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature communications. 13(1)
The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role of Akt2 signaling—integral to both RPE homeostasis and glucose