Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anastasia S. Singatulina"'
Autor:
Emilie Bertrand, Clément Demongin, Ioana Dobra, Juan Carlos Rengifo-Gonzalez, Anastasia S. Singatulina, Maria V. Sukhanova, Olga I. Lavrik, David Pastré, Loic Hamon
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract FUS is an RNA-binding protein involved in familiar forms of ALS and FTLD that also assembles into fibrillar cytoplasmic aggregates in some neurodegenerative diseases without genetic causes. The self-adhesive prion-like domain in FUS generate
Externí odkaz:
https://doaj.org/article/9379e4e83d2b416ebc9af2f57a01912f
Autor:
Anastasia S. Singatulina, Maria V. Sukhanova, Bénédicte Desforges, Vandana Joshi, David Pastré, Olga I. Lavrik
Publikováno v:
Cells, Vol 11, Iss 23, p 3932 (2022)
DNA damage causes PARP1 activation in the nucleus to set up the machinery responsible for the DNA damage response. Here, we report that, in contrast to cytoplasmic PARPs, the synthesis of poly(ADP-ribose) by PARP1 opposes the formation of cytoplasmic
Externí odkaz:
https://doaj.org/article/bd06beb7732d4dc2bed476bae8da8f5d
Autor:
Anastasia S. Singatulina, Loic Hamon, Maria V. Sukhanova, Bénédicte Desforges, Vandana Joshi, Ahmed Bouhss, Olga I. Lavrik, David Pastré
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1809-1821.e5 (2019)
Summary: PARP-1 synthesizes long poly(ADP-ribose) chains (PAR) at DNA damage sites to recruit DNA repair factors. Among proteins relocated on damaged DNA, the RNA-binding protein FUS is one of the most abundant, raising the issue about its involvemen
Externí odkaz:
https://doaj.org/article/3bbc96ff185d4201bd1f307312bfe809
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7020 (2020)
The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport and translation. I
Externí odkaz:
https://doaj.org/article/b943c8fa56a945d7b2f8e3563ca77751
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩
International Journal of Molecular Sciences, Vol 21, Iss 7020, p 7020 (2020)
International Journal of Molecular Sciences, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩
International Journal of Molecular Sciences, Vol 21, Iss 7020, p 7020 (2020)
International Journal of Molecular Sciences, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩
International audience; The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA tran