Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anastasia R. Kovrizhina"'
Autor:
Viacheslav V. Andrianov, Igor A. Schepetkin, Leah V. Bazan, Khalil L. Gainutdinov, Anastasia R. Kovrizhina, Dmitriy N. Atochin, Andrei I. Khlebnikov
Publikováno v:
Molecules, Vol 29, Iss 16, p 3820 (2024)
IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) is a specific c-Jun N-terminal kinase (JNK) inhibitor with anticancer and neuro- and cardioprotective properties. Because aryloxime derivatives undergo cytochrome P450-catalyzed oxidation to nitric oxid
Externí odkaz:
https://doaj.org/article/9c0065bbc8ac4449966bfa611087bc98
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1451 (2022)
Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new et
Externí odkaz:
https://doaj.org/article/5ed924f8c5da447b89d3440055a79d68
Autor:
Igor A. Schepetkin, Anastasia R. Kovrizhina, Ksenia S. Stankevich, Andrei I. Khlebnikov, Liliya N. Kirpotina, Mark T. Quinn, Matthew J. Cook
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell death. Therefore, JNK repre
Externí odkaz:
https://doaj.org/article/4dda9abd3b5a4a1480568deef666b6e7
Autor:
Mark B. Plotnikov, Galina A. Chernysheva, Vera I. Smol’yakova, Oleg I. Aliev, Anna M. Anishchenko, Olga A. Ulyakhina, Eugene S. Trofimova, Anastasia A. Ligacheva, Nina D. Anfinogenova, Anton N. Osipenko, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Igor A. Schepetkin, Anastasia G. Drozd, Evgenii V. Plotnikov, Dmitriy N. Atochin, Mark T. Quinn
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1057 (2023)
The activation of c-Jun N-terminal kinase (JNK) plays an important role in stroke outcomes. Tryptanthrin-6-oxime (TRYP-Ox) is reported to have high affinity for JNK and anti-inflammatory activity and may be of interest as a promising neuroprotective
Externí odkaz:
https://doaj.org/article/f8e06b8fec7049568f7fbab52351270e
Autor:
Vladislava V. Matveevskaya, Dmitry I. Pavlov, Anastasia R. Kovrizhina, Taisiya S. Sukhikh, Evgeniy H. Sadykov, Pavel V. Dorovatovskii, Vladimir A. Lazarenko, Andrei I. Khlebnikov, Andrei S. Potapov
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1802 (2023)
11H-Indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) and tryptanthrin-6-oxime are potent c-Jun N-terminal kinase 3 (JNK-3) inhibitors demonstrating neuroprotective, anti-inflammatory and anti-arthritic activity. However, the stereochemical configuration o
Externí odkaz:
https://doaj.org/article/784a6dccd29641498c2f0986e8156355
Autor:
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
Publikováno v:
Molecules, Vol 28, Iss 12, p 4806 (2023)
The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including cell proliferation and differentiation, cell survival, and inflammation. Because of emerging data suggesting that JNK3 may
Externí odkaz:
https://doaj.org/article/445a30aaa10b4b729290552c0e7addb1
Publikováno v:
Molbank, Vol 2021, Iss 4, p M1299 (2021)
11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxal
Externí odkaz:
https://doaj.org/article/ce46296ba4724a58a857fd121448294f
Autor:
Igor A. Schepetkin, Galina A. Chernysheva, Oleg I. Aliev, Liliya N. Kirpotina, Vera I. Smol’yakova, Anton N. Osipenko, Mark B. Plotnikov, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Evgenii V. Plotnikov, Mark T. Quinn
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2119 (2022)
The c-Jun N-terminal kinases (JNKs) regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell death. Therefore, JNKs represent attractive targets for therapeutic in
Externí odkaz:
https://doaj.org/article/954dadc088984656bafaaa8b1ac9138c
Autor:
Serhii A. Liakhov, Igor A. Schepetkin, Olexander S. Karpenko, Hanna I. Duma, Nadiia M. Haidarzhy, Liliya N. Kirpotina, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Irina Y. Bagryanskaya, Mark T. Quinn
Publikováno v:
Molecules, Vol 26, Iss 18, p 5688 (2021)
c-Jun N-terminal kinase (JNK) plays a central role in stress signaling pathways implicated in important pathological processes, including rheumatoid arthritis and ischemia-reperfusion injury. Therefore, inhibition of JNK is of interest for molecular
Externí odkaz:
https://doaj.org/article/1476c6744fc74009a7238aa4263c2755
Autor:
Alexander P Lakeev, Galina A Frelikh, Elena A Yanovskaya, Anastasia R Kovrizhina, Vladimir V Udut
Publikováno v:
Bioanalysis. 14:1423-1441
Background: IQ-1 is a promising c-Jun-N-terminal kinase inhibitor and nitrovasodilator. An LC–MS/MS method was validated to determine IQ-1 isomers and major metabolite IQ-18 in rat plasma. Materials & methods: The analytes were extracted using ethy