Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anastasia Noel"'
Ganglioside and related-sphingolipid profiles are altered in a cellular model of Alzheimer's disease
Publikováno v:
Biochimie. 137:158-164
Sphingolipid-related issues are increasingly discussed to contribute to the neuropathological process of Alzheimer's disease (AD). In this study, gangliosides and related-sphingolipids (ceramides, neutral glycosphingolipids and sphingomyelins) were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57de56a47dada1e7b50c8e425d4020bc
https://doi.org/10.1016/j.biochi.2017.03.019
https://doi.org/10.1016/j.biochi.2017.03.019
Publikováno v:
Molecular and Cellular Neuroscience. 75:63-70
Evidence has suggested that ganglioside abnormalities may be linked to the proteolytic processing of amyloid precursor protein (APP) in Alzheimer's disease (AD) and that pharmacological inhibition of ganglioside synthesis may reduce amyloid β-peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2eb92bf4e05e4c5720c46c4cfc18152
https://doi.org/10.1016/j.mcn.2016.06.009
https://doi.org/10.1016/j.mcn.2016.06.009
Publikováno v:
Life Sciences. 158:14-21
Aims GSK3β activation in Aβ conditions leading to tau phosphorylation at pathological sites is a well-known phenomenon. However, the serine/tyrosine phosphorylation processes implied in Aβ-induced GSK3β activation and responsible for tau phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d8e5937b461b4e59328bf2f75185d1
https://doi.org/10.1016/j.lfs.2016.06.020
https://doi.org/10.1016/j.lfs.2016.06.020
Publikováno v:
Experimental Neurology. 271:308-318
Accumulating evidence implicates ganglioside and/or related-sphingolipid disturbance in the pathogenesis of Alzheimer's disease (AD). However, it is not known whether these lipidic alterations are connected with other important features of AD, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e75da7badca2d78bfa0c4307360aa4
https://doi.org/10.1016/j.expneurol.2015.06.021
https://doi.org/10.1016/j.expneurol.2015.06.021
Publikováno v:
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease, Vol 2011 (2011)
International Journal of Alzheimer's Disease, Vol 2011 (2011)
There is evidence linking sphingolipid abnormalities, APP processing, and neuronal death in Alzheimer's disease (AD). We previously reported a strong elevation of ceramide levels in the brain of the APPSL/PS1Ki mouse model of AD, preceding the neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5f7737fbd0226d2b9f422263bc95fb
http://europepmc.org/articles/PMC3014734
http://europepmc.org/articles/PMC3014734
Autor:
Francois Rinaldi, Sabrina Ingrand, Bernard Fauconneau, Claire Hubert, Anastasia Noel, Laurence Barrier
Publikováno v:
Journal of neuroscience research. 89(5)
Glycogen synthase kinase 3β (GSK3β) activity is regulated by phosphorylation processes and regulates in turn through phosphorylation several proteins, including eukaryotic initiation factor 2B (eIF2B). Serine 9 phosphorylation of GSK3β (pGSK3βSer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678fde09fb89255fe4f724c6534f63e2
https://pubmed.ncbi.nlm.nih.gov/21360572
https://pubmed.ncbi.nlm.nih.gov/21360572
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-20 (2021)
Abstract Active Caspase-6 (Casp6) and Tau cleaved by Casp6 at amino acids 402 (Tau∆D402) and 421 (Tau∆D421) are present in early Alzheimer disease intraneuronal neurofibrillary tangles, which are made primarily of filamentous Tau aggregates. To a
Externí odkaz:
https://doaj.org/article/878d887ed0a84c58bcb339dd844db442
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of
Externí odkaz:
https://doaj.org/article/f9e708e8e4a94657bdc8e388bc81fd42
Autor:
Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P. Jesper Sjöström, Andrea C. LeBlanc
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Activated Caspase-6 (Casp6) is associated with age-dependent cognitive impairment and Alzheimer disease (AD). Mice expressing human Caspase-6 in hippocampal CA1 neurons develop age-dependent cognitive deficits, neurodegeneration and neuroinf
Externí odkaz:
https://doaj.org/article/485d6f972eff467a8be1a38aa3a0acaa
Publikováno v:
Toxicology Letters. 196:S223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eacc82775f06eb502493cb41d0e990b5
https://doi.org/10.1016/j.toxlet.2010.03.749
https://doi.org/10.1016/j.toxlet.2010.03.749