Placental genomics mediates genetic associations with complex health traits and disease

Autor: Arjun Bhattacharya, Anastasia N. Freedman, Vennela Avula, Rebeca Harris, Weifang Liu, Calvin Pan, Aldons J. Lusis, Robert M. Joseph, Lisa Smeester, Hadley J. Hartwell, Karl C. K. Kuban, Carmen J. Marsit, Yun Li, T. Michael O’Shea, Rebecca C. Fry, Hudson P. Santos

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The impact of placental transcriptomics on fetal traits throughout development is not well understood. Here, the authors apply distal-SNP-enriched transcriptome-wide association studies to detect genetic contributions, mediated through fetal placenta

Externí odkaz: https://doaj.org/article/f834790b97534f809de5e0b70af87c2e

The placenta epigenome–brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment

Autor: Anastasia N Freedman, Lauren A Eaves, Julia E Rager, Noemi Gavino-Lopez, Lisa Smeester, Jacqueline Bangma, Hudson P Santos, Robert M Joseph, Karl CK Kuban, Thomas Michael O'Shea, Rebecca C Fry

Publikováno v: Epigenomics. 14:897-911

Aim: The placenta–brain axis reflects a developmental linkage where disrupted placental function is associated with impaired neurodevelopment later in life. Placental gene expression and the expression of epigenetic modifiers such as miRNAs may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8fc9864e8fa206875a7436bf0518c3
https://doi.org/10.2217/epi-2022-0061

Placental genomics mediates genetic associations with complex health traits and disease

Autor: Arjun, Bhattacharya, Anastasia N, Freedman, Vennela, Avula, Rebeca, Harris, Weifang, Liu, Calvin, Pan, Aldons J, Lusis, Robert M, Joseph, Lisa, Smeester, Hadley J, Hartwell, Karl C K, Kuban, Carmen J, Marsit, Yun, Li, T Michael, O'Shea, Rebecca C, Fry, Hudson P, Santos

Publikováno v: Nature communications. 13(1)

As the master regulator in utero, the placenta is core to the Developmental Origins of Health and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene-trait associations (GTAs) across the life course, we perform dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::098ac2eef140367b2c5a9714f3636713
https://pubmed.ncbi.nlm.nih.gov/35121757

Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures in Houston, Texas

Autor: Cynthia Shope, Lisa Smeester, William Vizuete, Kjersti Aagaard, Julia E. Rager, Kenneth G. Sexton, Rebecca C. Fry, Barry Lefer, Anastasia N. Freedman, James Flynn, Lauren A. Eaves, Thomas Howard, Mathew H. Erickson, Hang Nguyen

Publikováno v: Environ Sci Technol

Atmospheric pollution represents a complex mixture of air chemicals that continually interact and transform, making it difficult to accurately evaluate associated toxicity responses representative of real-world exposure. This study leveraged data fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa59c8bbb6582e58eb3cdc9feb9408bb
https://pubmed.ncbi.nlm.nih.gov/33064461

New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing

Autor: Julia E. Rager, Anastasia N. Freedman, Mark Higuchi, Ilona Jaspers, John F. Wambaugh, John T Szilagyi, Jose Zavala

Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 6, p 2124 (2020)
International Journal of Environmental Research and Public Health

Air pollution consists of highly variable and complex mixtures recognized as major contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled with limitations surrounding epidemiological and animal studies, has necessita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbfac822ee26c98ed5538c72994d701
https://doi.org/10.3390/ijerph17062124