Výsledky vyhledávání - "Anastasia Mpakali"

Akademický článek

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

Autor: Galateia Georgaki, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displa

Externí odkaz: https://doaj.org/article/4249348d25da41e481a3ab41c6ab36f9

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Akademický článek

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Autor: George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response. Although ERAP1 can efficiently process long peptides

Externí odkaz: https://doaj.org/article/9bcf23927a2540dbb515f338c76f8451

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Akademický článek

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

Autor: Athanasios Papakyriakou, Anastasia Mpakali, Efstratios Stratikos

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses. Although th

Externí odkaz: https://doaj.org/article/7ea0205a0a92451ab34c0a6de1cb6427

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Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Publikováno v: Angewandte Chemie. 134

Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a key enzyme involved in the trimming of antigenic peptides presented by Major Histocompatibility Complex class I. It is a target of growing interest for the treatment of autoimmune diseases and in ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e811256da0e1a84c1cce3189a839b9
https://doi.org/10.1002/ange.202203560

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A Carbodiimide-Mediated P–C Bond-Forming Reaction: Mild Amidoalkylation of P-Nucleophiles by Boc-Aminals

Autor: Konstantinos D. Vogiatzis, Thayalan Rajeshkumar, Efstratios Stratikos, Dimitris Georgiadis, Paraskevi Kokkala, Anastasia Mpakali

Publikováno v: Organic Letters. 23:1726-1730

The first example of a carbodiimide-mediated P–C bond-forming reaction is described. The reaction involves activation of β-carboxyethylphosphinic acids and subsequent reaction with Boc-aminals usin...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff0497e4a662ea6b4104173e5b3c87c7
https://doi.org/10.1021/acs.orglett.1c00155

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Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Autor: Zachary Maben, Mats Larhed, Efstratios Stratikos, Lawrence J. Stern, Emmanuel N. Saridakis, Mathias Hallberg, Petros Giastas, Anastasia Mpakali

Publikováno v: ACS Med Chem Lett

[Image: see text] Insulin-regulated aminopeptidase (IRAP) is a transmembrane zinc metallopeptidase with many important biological functions and an emerging pharmacological target. Although previous structural studies have given insight on how IRAP re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33cd91382bbb6166397e900dce62c5c
https://doi.org/10.1021/acsmedchemlett.0c00172

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A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1

Autor: Richa Arya, Efstratios Stratikos, Angelos Lelis, Lawrence J. Stern, Robert Tampé, Anastasia Mpakali, Dimitris Georgiadis, George Mavridis, Antonia Vlahou, Jerome Zoidakis, Manousos Makridakis, Athanasios Papakyriakou, Alexander Domnick

Publikováno v: J Biol Chem

Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims antigenic peptide precursors to generate mature antigenic peptides for presentation by major histocompatibility complex class I (MHCI) molecules and regulates adaptive immune responses. ERAP1 has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4577250cc8d50d1d84d31c39695c0f69
https://doi.org/10.1074/jbc.ra120.012976

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Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin

Autor: Dionisios Vourloumis, Ioannis Mavridis, Alexandros Athanasoulis, Ioannis Temponeras, Despoina Koumantou, Petros Giastas, Anastasia Mpakali, Victoria Magrioti, Jacqueline Leib, Peter van Endert, Efstratios Stratikos, Athanasios Papakyriakou

Publikováno v: Journal of medicinal chemistry 65(14), 10098-10117 (2022). doi:10.1021/acs.jmedchem.2c00904

Journal of medicinal chemistry 65(14), 10098 - 10117 (2022). doi:10.1021/acs.jmedchem.2c00904
The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8943044d98ebc7f8b9add9dfb3a96c0b
https://bib-pubdb1.desy.de/record/481559

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Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

Autor: Paraskevi Kokkala, Aggelos Lelis, Athanasios Papakyriakou, John Liddle, Petros Giastas, Paul Rowland, Margarete Neu, Anastasia Mpakali, Dimitris Georgiadis, Efstratios Stratikos

Publikováno v: Proc Natl Acad Sci U S A

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that optimizes the peptide cargo of major histocompatibility class I (MHC-I) molecules and regulates adaptive immunity. It has unusual substrate selectivity for length and sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedf510ed32284780a48d69efa58d2ab
https://doi.org/10.1073/pnas.1912070116

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Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2

Autor: Anastasia Mpakali, Dimitris Georgiadis, Efstratios Stratikos, Petros Giastas

Publikováno v: ACS Med Chem Lett

[Image: see text] Endoplasmic reticulum aminopeptidase 2 (ERAP2) is an intracellular enzyme involved in the processing of antigenic peptides intended for presentation by major histocompatibility complex class I (MHCI) molecules. Because of its role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6899c770209b141c5cf911e4dc8ed3d
https://pubmed.ncbi.nlm.nih.gov/35178178

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