Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anastasia M. Kochurova"'
Autor:
Galina V. Kopylova, Anastasia M. Kochurova, Daria S. Yampolskaya, Victoria V. Nefedova, Andrey K. Tsaturyan, Natalia A. Koubassova, Sergey Y. Kleymenov, Dmitrii I. Levitsky, Sergey Y. Bershitsky, Alexander M. Matyushenko, Daniil V. Shchepkin
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8340
In the myocardium, the TPM1 gene expresses two isoforms of tropomyosin (Tpm), alpha (αTpm; Tpm 1.1) and kappa (κTpm; Tpm 1.2). κTpm is the result of alternative splicing of the TPM1 gene. We studied the structural features of κTpm and its regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a73973d1e9b4c11f7068478c0bbfce5
Autor:
Andrey K. Tsaturyan, Elena V. Zaklyazminskaya, Margarita E. Polyak, Galina V. Kopylova, Daniil V. Shchepkin, Anastasia M. Kochurova, Anastasiia D. Gonchar, Sergey Y. Kleymenov, Natalia A. Koubasova, Sergey Y. Bershitsky, Alexander M. Matyushenko, Dmitrii I. Levitsky
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 18
Hypertrophic cardiomyopathy (HCM), caused by mutations in thin filament proteins, manifests as moderate cardiac hypertrophy and is associated with sudden cardiac death (SCD). We identified a new de novo variant, c.656A>T (p.D219V), in the TPM1 gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe4d2e3cb8bb53b1fdeba5b061fffac
Autor:
Valentina Y. Berg, Alexander M. Matyushenko, Anastasia M. Kochurova, Dmitrii I. Levitsky, Sergey Yu. Kleymenov, Anastasiia D. Gonchar, Andrey K. Tsaturyan, Galina V. Kopylova, Natalia A. Koubasova, D. V. Shchepkin
Publikováno v:
Biochemical and Biophysical Research Communications. 534:8-13
Tropomyosin (Tpm) is an actin-binding protein that plays a crucial role in the regulation of muscle contraction. Numerous point mutations in the TPM3 gene encoding Tpm of slow skeletal muscles (Tpm 3.12 or γ-Tpm) are associated with the genesis of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced1bfa5211e9ae93beedcc3aee2d966
https://doi.org/10.1016/j.bbrc.2020.11.103
https://doi.org/10.1016/j.bbrc.2020.11.103
Autor:
Victoria V. Nefedova, Galina V. Kopylova, Daniil V. Shchepkin, Anastasia M. Kochurova, Olga I. Kechko, Vera A. Borzova, Natalia S. Ryabkova, Ivan A. Katrukha, Vladimir A. Mitkevich, Sergey Y. Bershitsky, Dmitrii I. Levitsky, Alexander M. Matyushenko
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15723
Tropomyosin (Tpm) mutations cause inherited cardiac diseases such as hypertrophic and dilated cardiomyopathies. We applied various approaches to investigate the role of cardiac troponin (Tn) and especially the troponin T (TnT) in the pathogenic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b365e0addc1992fad217ed2a945193
https://doi.org/10.3390/ijms232415723
https://doi.org/10.3390/ijms232415723
Autor:
Galina V. Kopylova, Valentina Y. Berg, Anastasia M. Kochurova, Alexander M. Matyushenko, Sergey Y. Bershitsky, Daniil V. Shchepkin
Publikováno v:
Biochemical and biophysical research communications. 588
The molecular mechanisms of pathogenesis of atrial myopathy associated with hypertrophic (HCM) and dilated (DCM) mutations of sarcomeric proteins are still poorly understood. For this, one needs to investigate the effects of the mutations on actin-my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa555ee4db74dd709a50b8b08583e267
https://pubmed.ncbi.nlm.nih.gov/34942531
https://pubmed.ncbi.nlm.nih.gov/34942531
Autor:
Xenia Butova, D. A. Kuznetsov, Anastasia M. Kochurova, Valentina Y. Berg, Anastasia Khokhlova, Galina V. Kopylova, E. A. Mukhlynina, Denis Volzhaninov, D. V. Shchepkin, Tatiana Myachina
Publikováno v:
Biochemical and biophysical research communications. 541
Estrogen deficiency has a significant influence on the excitation-contraction coupling in the ventricular myocardium but its impact on the atrial contractile function has not been studied. We have compared the effects of estrogen deficiency on the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615e03ef5f5fa66a96d8e85c15d8a696
https://pubmed.ncbi.nlm.nih.gov/33461065
https://pubmed.ncbi.nlm.nih.gov/33461065
Autor:
Valentina Y. Berg, L.V. Nikitina, Sergey Y. Bershitsky, Anastasia M. Kochurova, Galina V. Kopylova, D. V. Shchepkin, S. R. Nabiev
Publikováno v:
Biochemical and biophysical research communications. 528(4)
Omecamtiv mecarbil (OM), an activator of cardiac myosin, strongly affects contractile characteristics of the ventricles and, to a much lesser extent, the characteristics of atrial contraction. We compared the molecular mechanism of action of OM on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e35a0203bd55e1317b6fd54817f6dc5
https://pubmed.ncbi.nlm.nih.gov/32513536
https://pubmed.ncbi.nlm.nih.gov/32513536