Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anastasia Leshchyk"'
Autor:
Rui Hong, Yusuke Koga, Shruthi Bandyadka, Anastasia Leshchyk, Yichen Wang, Vidya Akavoor, Xinyun Cao, Irzam Sarfraz, Zhe Wang, Salam Alabdullatif, Frederick Jansen, Masanao Yajima, W. Evan Johnson, Joshua D. Campbell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Quality control (QC) is a crucial step in single-cell RNA-seq data analysis. Here, the authors present the SCTK-QC pipeline which generates and visualizes a comprehensive set of QC metrics to streamline the process of detecting and removing poor qual
Externí odkaz:
https://doaj.org/article/3b9c0a0a78f74f97957e4f3059d88d39
Autor:
Anastasia Gurinovich, Mengze Li, Anastasia Leshchyk, Harold Bae, Zeyuan Song, Konstantin G. Arbeev, Marianne Nygaard, Mary F Feitosa, Thomas T Perls, Paola Sebastiani
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Performing a genome-wide association study (GWAS) with a binary phenotype using family data is a challenging task. Using linear mixed effects models is typically unsuitable for binary traits, and numerical approximations of the likelihood function ma
Externí odkaz:
https://doaj.org/article/96cf8acaa04848d8b4ecf9dc4146bb49
Autor:
Harold Bae, Anastasia Gurinovich, Tanya T. Karagiannis, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Stacy L. Andersen, Konstantin Arbeev, Anatoliy Yashin, Joseph Zmuda, Ping An, Mary Feitosa, Cristina Giuliani, Claudio Franceschi, Paolo Garagnani, Jonas Mengel-From, Gil Atzmon, Nir Barzilai, Annibale Puca, Nicholas J. Schork, Thomas T. Perls, Paola Sebastiani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 116 (2022)
We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls
Externí odkaz:
https://doaj.org/article/c86a1dc252e44e8eb7d4ed06ccb20279
Autor:
Anastasia Leshchyk, Qingyan Xiang, Stacy L Andersen, Anastasia Gurinovich, Zeyuan Song, Joseph H Lee, Kaare Christensen, Anatoliy Yashin, Mary Wojczynski, Karen Schwander, Thomas T Perls, Stefano Monti, Paola Sebastiani
Publikováno v:
The Journals of Gerontology: Series A.
Mosaic chromosomal alterations (mCAs) are structural alterations associated with aging, cancer, cardiovascular disease, infectious diseases, and mortality. The distribution of mCAs in centenarians and individuals with familial longevity is poorly und
Autor:
Paola Sebastiani, Zeyuan Song, Dylan Ellis, Qu Tian, Michaela Schwaiger-Haber, Ethan Stancliffe, Michael S. Lustgarten, Cory C. Funk, Priyanka Baloni, Cong-Hui Yao, Shakchhi Joshi, Megan M. Marron, Anastasia Gurinovich, Mengze Li, Anastasia Leshchyk, Qingyan Xiang, Stacy L. Andersen, Mary F. Feitosa, Svetlana Ukraintseva, Mette Soerensen, Oliver Fiehn, Jose M. Ordovas, Marcia Haigis, Stefano Monti, Nir Barzilai, Sofiya Milman, Luigi Ferrucci, Noa Rappaport, Gary J. Patti, Thomas T. Perls
Publikováno v:
GeroScience
GeroScience, vol 45, iss 1
GeroScience, vol 45, iss 1
With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein E (APOE) gene, we established a consortium of five studies of healthy aging and extreme human longevity with 3545 participants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca413fec14b98b890fabcfd22970cf7
https://europepmc.org/articles/PMC9886693/
https://europepmc.org/articles/PMC9886693/
Autor:
Harold Bae, Anastasia Gurinovich, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Nir Barzilai, Thomas Perls, Paola Sebastiani
Publikováno v:
Innovation in Aging. 6:445-446
The meta-analysis of extreme longevity (EL) conducted in 2017 using a consortium of four longevity studies—the New England Centenarian Study (NECS), the Long Life Family Study (LLFS), the Southern Italian Centenarian Study (SICS), and the Longevity
Autor:
Anastasia Gurinovich, Harold Bae, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Stacy Andersen, Thomas Perls, Paola Sebastiani
Publikováno v:
Innovation in Aging. 6:395-395
Extreme longevity (EL) runs in families which supports the hypothesis that this is a genetically regulated trait. However, with the exception of APOE, genome-wide association studies (GWAS) of EL have not identified many genetic variants that replica
Autor:
Anastasia Leshchyk, Qingyan Xiang, Stefano Monti, Thomas Perls, Stacy Andersen, Anastasia Gurinovich, Zeyuan Song, Paola Sebastiani
Publikováno v:
Innovation in Aging. 6:131-131
Mosaic chromosomal alterations (mCAs) are structural alterations that are associated with mortality, age, cancer, cardiovascular disease, and diverse infections. The distribution of mCAs in long-lived subjects and individuals with familial longevity
Autor:
W. Evan Johnson, Irzam Sarfraz, Frederick Jansen, Shruthi Bandyadka, Yichen Wang, Salam Alabdullatif, Xinyun Cao, Zhe Wang, Yusuke Koga, Vidya Akavoor, Masanao Yajima, Joshua D. Campbell, Rui Hong, Anastasia Leshchyk
Single-cell RNA sequencing (scRNA-seq) can be used to gain insights into cellular heterogeneity within complex tissues. However, a variety of technical artifacts can be present in scRNA-seq data and need to be assessed before downstream analyses can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4c2a4d9bb379007156937035424cb0
https://doi.org/10.1101/2020.11.16.385328
https://doi.org/10.1101/2020.11.16.385328
Publikováno v:
RNA
Single-cell RNA sequencing (scRNA-seq) is a recent technology that enables fine-grained discovery of cellular subtypes and specific cell states. Analysis of scRNA-seq data routinely involves machine learning methods, such as feature learning, cluster