Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Anastasia Gurinovich"'
Autor:
Mengze Li, Zeyuan Song, Anastasia Gurinovich, Nicholas Schork, Paola Sebastiani, Stefano Monti
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0298501 (2024)
Quantitative trait loci (QTL) denote regions of DNA whose variation is associated with variations in quantitative traits. QTL discovery is a powerful approach to understand how changes in molecular and clinical phenotypes may be related to DNA sequen
Externí odkaz:
https://doaj.org/article/2b080d36b75b4fe687b355284cd1a286
Autor:
Anastasia Gurinovich, Mengze Li, Anastasia Leshchyk, Harold Bae, Zeyuan Song, Konstantin G. Arbeev, Marianne Nygaard, Mary F Feitosa, Thomas T Perls, Paola Sebastiani
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Performing a genome-wide association study (GWAS) with a binary phenotype using family data is a challenging task. Using linear mixed effects models is typically unsuitable for binary traits, and numerical approximations of the likelihood function ma
Externí odkaz:
https://doaj.org/article/96cf8acaa04848d8b4ecf9dc4146bb49
Autor:
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010093 (2022)
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous stu
Externí odkaz:
https://doaj.org/article/9c0268137d414840bbba8d1073dcccdf
Autor:
Harold Bae, Anastasia Gurinovich, Tanya T. Karagiannis, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Stacy L. Andersen, Konstantin Arbeev, Anatoliy Yashin, Joseph Zmuda, Ping An, Mary Feitosa, Cristina Giuliani, Claudio Franceschi, Paolo Garagnani, Jonas Mengel-From, Gil Atzmon, Nir Barzilai, Annibale Puca, Nicholas J. Schork, Thomas T. Perls, Paola Sebastiani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 116 (2022)
We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls
Externí odkaz:
https://doaj.org/article/c86a1dc252e44e8eb7d4ed06ccb20279
Autor:
Zeyuan Song, Anastasia Gurinovich, Marianne Nygaard, Jonas Mengel-From, Stacy Andersen, Stephanie Cosentino, Nicole Schupf, Joseph Lee, Joseph Zmuda, Svetlana Ukraintseva, Konstantin Arbeev, Kaare Christensen, Thomas Perls, Paola Sebastiani
Publikováno v:
Neurobiology of Aging. 125:115-122
We conducted a genome-wide association study (GWAS) of Digit Symbol Substitution Test (DSST) scores administered in 4207 family members of the Long Life Family Study (LLFS). Genotype data were imputed to the HRC panel of 64,940 haplotypes resulting i
Autor:
Anastasia Leshchyk, Qingyan Xiang, Stacy L Andersen, Anastasia Gurinovich, Zeyuan Song, Joseph H Lee, Kaare Christensen, Anatoliy Yashin, Mary Wojczynski, Karen Schwander, Thomas T Perls, Stefano Monti, Paola Sebastiani
Publikováno v:
The Journals of Gerontology: Series A.
Mosaic chromosomal alterations (mCAs) are structural alterations associated with aging, cancer, cardiovascular disease, infectious diseases, and mortality. The distribution of mCAs in centenarians and individuals with familial longevity is poorly und
Autor:
Timothy Estabrooks, Anastasia Gurinovich, Jodie Pietruska, Benjamin Lewis, Garrett Harvey, Gerald Post, Lindsay Lambert, Lucas Rodrigues, Michelle E. White, Christina Lopes, Cheryl A. London, Kate Megquier
BackgroundCanine hemangiosarcoma (HSA) is an aggressive cancer of endothelial cells associated with short survival times. Understanding the genomic landscape of HSA is critical to developing more effective therapeutic strategies.ObjectivesTo determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f96009aded31948f9bd6dc93541ec9
https://doi.org/10.1101/2022.11.17.516327
https://doi.org/10.1101/2022.11.17.516327
Autor:
Paola Sebastiani, Zeyuan Song, Dylan Ellis, Qu Tian, Michaela Schwaiger-Haber, Ethan Stancliffe, Michael S. Lustgarten, Cory C. Funk, Priyanka Baloni, Cong-Hui Yao, Shakchhi Joshi, Megan M. Marron, Anastasia Gurinovich, Mengze Li, Anastasia Leshchyk, Qingyan Xiang, Stacy L. Andersen, Mary F. Feitosa, Svetlana Ukraintseva, Mette Soerensen, Oliver Fiehn, Jose M. Ordovas, Marcia Haigis, Stefano Monti, Nir Barzilai, Sofiya Milman, Luigi Ferrucci, Noa Rappaport, Gary J. Patti, Thomas T. Perls
Publikováno v:
GeroScience
GeroScience, vol 45, iss 1
GeroScience, vol 45, iss 1
With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein E (APOE) gene, we established a consortium of five studies of healthy aging and extreme human longevity with 3545 participants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca413fec14b98b890fabcfd22970cf7
https://europepmc.org/articles/PMC9886693/
https://europepmc.org/articles/PMC9886693/
Publikováno v:
Journal of open source software. 6(59)
A tool for conducting Genome-Wide Association Study (GWAS) in a systematic, automated and reproducible manner is overdue. We developed an automated GWAS pipeline by combining multiple analysis tools - including bcftools, vcftools, the R packages SNPR
Autor:
Harold Bae, Anastasia Gurinovich, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Nir Barzilai, Thomas Perls, Paola Sebastiani
Publikováno v:
Innovation in Aging. 6:445-446
The meta-analysis of extreme longevity (EL) conducted in 2017 using a consortium of four longevity studies—the New England Centenarian Study (NECS), the Long Life Family Study (LLFS), the Southern Italian Centenarian Study (SICS), and the Longevity