Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anastasia G. Henry"'
Autor:
Xiang Wang, Elvira Negrou, Michael T. Maloney, Vitaliy V. Bondar, Shan V. Andrews, Manuel Montalban, Ceyda Llapashtica, Romeo Maciuca, Hoang Nguyen, Hilda Solanoy, Annie Arguello, Laralynne Przybyla, Nathan J. Moerke, Sarah Huntwork-Rodriguez, Anastasia G. Henry
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 k
Externí odkaz:
https://doaj.org/article/1aca3cf646994a96a51018658104a0b3
Autor:
Annie Arguello, René Meisner, Elliot R. Thomsen, Hoang N. Nguyen, Ritesh Ravi, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Thomas M. Gill, Darren Chan, Yuhsiang Cheng, Chi-Lu Chiu, Jason C. Dugas, Meng Fang, Isabel A. Lopez, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, Kirk R. Henne, Anastasia G. Henry, Anthony Delucchi, Simona Costanzo, Jeffrey M. Harris, Dolores Diaz, Kimberly Scearce-Levie, Pascal E. Sanchez
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in cellular accumulation of glycosaminoglycans (GAGs) throughout the body. Treatment of MPS II remains a
Externí odkaz:
https://doaj.org/article/7257efca6a4647a28c441e395328432c
Autor:
Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Marcus Y Chin, Audrey Cheuk-Nga Ho, Rajarshi Ghosh, Dara E Leto, David Joy, Meredith EK Calvert, Joseph W Lewcock, Gilbert Di Paolo, Robert G Thorne, Zachary K Sweeney, Anastasia G Henry
Publikováno v:
eLife, Vol 12 (2023)
Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis includ
Externí odkaz:
https://doaj.org/article/1459c4b9a28a4c35be189566695ad7a3
Autor:
Danna Jennings, Sarah Huntwork‐Rodriguez, Maurits F.J.M. Vissers, Vinay M. Daryani, Dolores Diaz, Marisa S. Goo, John J. Chen, Romeo Maciuca, Kyle Fraser, Omar S. Mabrouk, Jeroen van de Wetering de Rooij, Jules A.A.C. Heuberger, Geert Jan Groeneveld, Marie T. Borin, Andrés Cruz‐Herranz, Danielle Graham, Kimberly Scearce‐Levie, Javier De Vicente, Anastasia G. Henry, Peter Chin, Carole Ho, Matthew D. Troyer
Publikováno v:
Movement Disorders. 38:386-398
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d841a1a342eb88953aff7521961de4ba
https://doi.org/10.1002/mds.29297
https://doi.org/10.1002/mds.29297
Autor:
Vitaliy V. Bondar, Xiang Wang, Oliver B. Davis, Michael T. Maloney, Maayan Agam, Marcus Y. Chin, Audrey Cheuk-Nga Ho, David Joy, Joseph W. Lewcock, Gilbert Di Paolo, Robert G. Thorne, Zachary K. Sweeney, Anastasia G. Henry
Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e3b9441d471cebda4108d94643d132
https://doi.org/10.1101/2023.02.21.529466
https://doi.org/10.1101/2023.02.21.529466
Autor:
Michael T. Maloney, Xiang Wang, Rajarshi Ghosh, Shan V. Andrews, Romeo Maciuca, Shababa T. Masoud, Richard M. Caprioli, John Chen, Chi-Lu Chiu, Sonnet S. Davis, Audrey Cheuk-Nga Ho, Hoang N. Nguyen, Nicholas E. Propson, Michelle L. Reyzer, Oliver B. Davis, Matthew C. Deen, Sha Zhu, Gilbert Di Paolo, David J. Vocadlo, Anthony A. Estrada, Javier de Vicente, Joseph W. Lewcock, Annie Arguello, Jung H. Suh, Sarah Huntwork-Rodriguez, Anastasia G. Henry
Lysosomal dysfunction is a hallmark of Parkinson’s disease (PD), and variants in several PD-associated genes, includingLRRK2, perturb lysosomal homeostasis. Based on this, LRRK2 kinase inhibition is being explored as a therapeutic approach for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc13473cd36348881c86cb13ff023e4d
https://doi.org/10.1101/2022.12.19.521070
https://doi.org/10.1101/2022.12.19.521070
Autor:
Danna Jennings, Sarah Huntwork-Rodriguez, Anastasia G. Henry, Jennifer C. Sasaki, René Meisner, Dolores Diaz, Hilda Solanoy, Xiang Wang, Elvira Negrou, Vitaliy V. Bondar, Rajarshi Ghosh, Michael T. Maloney, Nicholas E. Propson, Yuda Zhu, Romeo D. Maciuca, Laura Harris, Angela Kay, Peter LeWitt, T. Alex King, Drew Kern, Aaron Ellenbogen, Ira Goodman, Andrew Siderowf, Jason Aldred, Omid Omidvar, Shababa T. Masoud, Sonnet S. Davis, Annie Arguello, Anthony A. Estrada, Javier de Vicente, Zachary K. Sweeney, Giuseppe Astarita, Marie T. Borin, Bradley K. Wong, Harvey Wong, Hoang Nguyen, Kimberly Scearce-Levie, Carole Ho, Matthew D. Troyer
Publikováno v:
Science Translational Medicine. 14
Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common genetic risk factors for Parkinson’s disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal function and may contribute to the pathogenesis of PD. Thus, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d447b718b56152fa35afc4ad299bcf
https://doi.org/10.1126/scitranslmed.abj2658
https://doi.org/10.1126/scitranslmed.abj2658
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme
Autor:
Annie Arguello, Cathal S. Mahon, Meredith E.K. Calvert, Darren Chan, Jason C. Dugas, Michelle E. Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A. Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N. Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C. Ullman, Junhua Wang, Mark S. Dennis, Dolores Diaz, Kannan Gunasekaran, Kirk R. Henne, Joseph W. Lewcock, Pascal E. Sanchez, Matthew D. Troyer, Jeffrey M. Harris, Kimberly Scearce-Levie, Lu Shan, Ryan J. Watts, Robert G. Thorne, Anastasia G. Henry, Mihalis S. Kariolis
Publikováno v:
Journal of Experimental Medicine. 219
Delivery of biotherapeutics across the blood–brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f8502d8d835baeb28ac3730bfbbf0e
https://doi.org/10.1084/jem.20211057
https://doi.org/10.1084/jem.20211057
Autor:
Ryan J. Watts, Kathryn M. Monroe, Junhua Wang, Melina Lenser, Jennifer Hsiao-Nakamoto, Hoang Nguyen, Todd P. Logan, Do Jin Kim, Fen Huang, Ritesh Ravi, Gilbert Di Paolo, Anil Rana, Kannan Gunasekaran, Yaneth Robles-Colmenares, Gerald M. Cherf, Buyankhishig Tsogtbaatar, Ceyda Llapashtica, Kirk R. Henne, Hilda Solanoy, Pascal E. Sanchez, Yashas Rajendra, Mihalis Kariolis, Ray Lieh Yoon Low, Roni Chau, Laralynne Przybyla, Michelle E. Pizzo, Chi-Lu Chiu, Meng Fang, Anastasia G. Henry, Giuseppe Astarita, Mark S. Dennis, Adam L. Boxer, Sarah L. DeVos, Sonnet S. Davis, Hilary W. Heuer, René Meisner, Joseph W. Lewcock, Devendra B. Srivastava, Bradley F. Boeve, Meredith E. K. Calvert, Katrina W. Lexa, Rachel Prorok, Lukas L. Skuja, Dolores Diaz, Akhil Bhalla, Matthew Simon, Jung H. Suh, Ankita Srivastava, Timothy K. Earr, Howard J. Rosen, Joseph Duque, Bettina Van Lengerich, Elizabeth W. Sun
Publikováno v:
Cell
Cell, vol 184, iss 18
Cell, vol 184, iss 18
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn(−/−) mice exhibit a global deficiency in bis(monoacylglycero)phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e8760616b55660b5a69ea73b7ad6da
https://europepmc.org/articles/PMC8489356/
https://europepmc.org/articles/PMC8489356/
Molecular architecture determines brain delivery of a transferrin-receptor targeted lysosomal enzyme
Autor:
Kirk R. Henne, Kimberly Scearce-Levie, Annie Arguello, Ullman Julie, Mihalis Kariolis, Tina Giese, Jeffrey M. Harris, Matthew D. Troyer, Kannan Gunasekaran, Meredith E. K. Calvert, Dolores Diaz, Anastasia G. Henry, Elliot R. Thomsen, Buyankhishig Tsogtbaatar, Roni Chau, Isabel Lopez, Joseph W. Lewcock, Cathal Mahon, Michelle E. Pizzo, Lu Shan, Darren Chan, Meng Fang, Pascal E. Sanchez, Robert G. Thorne, Timothy K. Earr, Ryan J. Watts, Joseph Duque, Lorna A. Damo, Mark S. Dennis, Hoang N. Nguyen, Do Jin Kim, Junhua Wang, Nicholas Liang, Hilda Solanoy, Jason C. Dugas
Delivery of biotherapeutics across the blood-brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ae90ba1655eaabdb89b5f77c6a55a6f
https://doi.org/10.1101/2021.05.21.445035
https://doi.org/10.1101/2021.05.21.445035