Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Autor: Jelena Konstantinović, Andreas M. Kany, Alaa Alhayek, Ahmed S. Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schönauer, Robert Bals, Hans Brandstetter, Rolf W. Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Müller, Katharina Rox, Jörg Haupenthal, Anna K.H. Hirsch

Publikováno v: ACS Central Science, Vol 9, Iss 12, Pp 2205-2215 (2023)

Externí odkaz: https://doaj.org/article/ea30f522c5d744fdb5b1cfb4ff499d72

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Autor: Cansu Kaya, Isabell Walter, Alaa Alhayek, Roya Shafiei, Gwenaëlle Jézéquel, Anastasia Andreas, Jelena Konstantinović, Esther Schönauer, Asfandyar Sikandar, Jörg Haupenthal, Rolf Müller, Hans Brandstetter, Rolf W. Hartmann, Anna K.H. Hirsch

Publikováno v: ACS Infectious Diseases. 8:1010-1021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e0cc9f4ee20ede994b9052aeda07de0
https://doi.org/10.1021/acsinfecdis.1c00628

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Autor: Di Zhu, Sandra Johannsen, Tiziana Masini, Céline Simonin, Jörg Haupenthal, Boris Illarionov, Anastasia Andreas, Mahendra Awale, Robin M. Gierse, Tridia van der Laan, Ramon van der Vlag, Rita Nasti, Mael Poizat, Eric Buhler, Norbert Reiling, Rolf Müller, Markus Fischer, Jean-Louis Reymond, Anna K. H. Hirsch

Publikováno v: Chemical Science, 13(36), 10686-10698. ROYAL SOC CHEMISTRY
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g

In the present manuscript, we describe how we successfully used ligand-based virtual screening (LBVS) to identify two small-molecule, drug-like hit classes with excellent ADMET profiles against the difficult to address microbial enzyme 1-deoxy-D-xylu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d037a73a79e9b4607948d4bb961dcdb1
https://research.rug.nl/en/publications/47d91e4b-c3e0-48f1-b774-6f2c690412a0

Phosphonate as a Stable Zinc‐Binding Group for 'Pathoblocker' Inhibitors of Clostridial Collagenase H (ColH)

Autor: Rolf Müller, Hans Brandstetter, Rolf W. Hartmann, Anastasia Andreas, Esther Schönauer, Christian Ducho, Jörg Haupenthal, Alaa Alhayek, Anna K. H. Hirsch, Katrin Voos

Publikováno v: Chemmedchem

Microbial infections are a significant threat to public health, and resistance is on the rise, so new antibiotics with novel modes of action are urgently needed. The extracellular zinc metalloprotease collagenase H (ColH) from Clostridium histolyticu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3fac8bdb4f44b6c26b1f5fd2b58304
http://europepmc.org/articles/PMC8251769

Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives

Autor: Walter Hofer, Emilia Oueis, Antoine Abou Fayad, Felix Deschner, Anastasia Andreas, Laìs Pessanha de Carvalho, Stephan Hüttel, Steffen Bernecker, Linda Pätzold, Bernd Morgenstern, Nestor Zaburannyi, Markus Bischoff, Marc Stadler, Jana Held, Jennifer Herrmann, Rolf Müller

Publikováno v: Angewandte Chemie (International ed. in English). 61(30)

The rise of antimicrobial resistance poses a severe threat to public health. The natural product chlorotonil was identified as a new antibiotic targeting multidrug resistant Gram-positive pathogens and Plasmodium falciparum. Although chlorotonil show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda7be105886d98fbfe21bd368059127
https://pubmed.ncbi.nlm.nih.gov/35485800