Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Anastasia Andreadaki"'
Autor:
Marco Leibinger, Charlotte Zeitler, Miriam Paulat, Philipp Gobrecht, Alexander Hilla, Anastasia Andreadaki, Rainer Guthoff, Dietmar Fischer
Publikováno v:
eLife, Vol 12 (2023)
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of Pten knockout or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allowi
Externí odkaz:
https://doaj.org/article/ba03f88517c04c51a9fe454aa6c3094c
Autor:
Marco Leibinger, Charlotte Zeitler, Philipp Gobrecht, Anastasia Andreadaki, Günter Gisselmann, Dietmar Fischer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The CNS has limited ability to regenerate following injury, Here, the authors show that a single injection of AAV-hyper-interleukin-6 in the sensory motor cortex results in corticospinal and raphe spinal tracts regeneration in the injured spinal cord
Externí odkaz:
https://doaj.org/article/d04a0d94e0664f95b2ee84617b7516de
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Muscle lim protein (MLP) has long been regarded as a cytosolic and nuclear muscular protein. Here, we show that MLP is also expressed in a subpopulation of adult rat dorsal root ganglia (DRG) neurons in response to axonal injury, while the p
Externí odkaz:
https://doaj.org/article/ecc4ac228ffb400ab40fff9b4b8d38f9
Autor:
Annemarie Heskamp, Marco Leibinger, Anastasia Andreadaki, Philipp Gobrecht, Heike Diekmann, Dietmar Fischer
Publikováno v:
Neurobiology of Disease, Vol 55, Iss , Pp 76-86 (2013)
Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons, but undergo apoptosis soon after axotomy. Besides the insufficient intrinsic capability of mature neurons to regrow axons inhibitory molecules located in myelin of the cen
Externí odkaz:
https://doaj.org/article/e8e5ffa16c9d43d38d821ce5e857f0c8
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 2, Pp 314-324 (2012)
Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons, but degenerate after axotomy. However, inflammatory stimulation (IS) enables RGCs to survive axotomy and regenerate axons in the injured optic nerve. Similar effects are a
Externí odkaz:
https://doaj.org/article/5eabe9eed9314e3e80289326bf66a6f3
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100756 (2014)
Muscle LIM protein (MLP) is a member of the cysteine rich protein family and has so far been regarded as a muscle-specific protein that is mainly involved in myogenesis and the organization of cytoskeletal structure in myocytes, respectively. The cur
Externí odkaz:
https://doaj.org/article/5ba18b33c76c488783ee836109620aec
Autor:
Annemarie Heskamp, Marco Leibinger, Anastasia Andreadaki, Philipp Gobrecht, Heike Diekmann, Dietmar Fischer
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 1-2 (2013)
Externí odkaz:
https://doaj.org/article/12d8dcafa94a4e9c8f17ce64ed0180c2
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
Communications Biology
Knockout of phosphatase and tensin homolog (PTEN−/−) is neuroprotective and promotes axon regeneration in mature neurons. Elevation of mTOR activity in injured neurons has been proposed as the primary underlying mechanism. Here we demonstrate tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14d03bd418de9a0ae536975cbde7cb2
http://link.springer.com/article/10.1038/s42003-019-0524-1
http://link.springer.com/article/10.1038/s42003-019-0524-1
Publikováno v:
Proc Natl Acad Sci U S A
Regenerative failure in the mammalian optic nerve is generally attributed to axotomy-induced retinal ganglion cell (RGC) death, an insufficient intrinsic regenerative capacity, and an extrinsic inhibitory environment. Here, we show that a chemoattrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8c64021e03f642400c8fa138eaaa86
https://pubmed.ncbi.nlm.nih.gov/34011605
https://pubmed.ncbi.nlm.nih.gov/34011605
Spinal cord injury (SCI) often causes severe and permanent disabilities. The current study uses a transneuronal approach to stimulate spinal cord regeneration by AAV-hyper-IL-6 (hIL-6) application after injury. While preinjury PTEN knockout in cortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc167862825ed81d4aacfd72aee7213
