Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anastasia, Loktev"'
Autor:
Thomas Lindner, Anastasia Loktev, Frederik Giesel, Clemens Kratochwil, Annette Altmann, Uwe Haberkorn
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-15 (2019)
Abstract Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors such as migration, metastasis, res
Externí odkaz:
https://doaj.org/article/c5c57423a62d47ebb104384eb87ca97d
Autor:
Jürgen Debus, Thomas Lindner, Susanne Krämer, Clemens Kratochwil, Anastasia Loktev, Frederik Marmé, Annette Altmann, Christian Kleist, Uwe Haberkorn, Walter Mier, Frederik L. Giesel
Publikováno v:
Journal of Nuclear Medicine. 61:1507-1513
Most epithelial tumors recruit fibroblasts and other nonmalignant cells and activate them into cancer-associated fibroblasts. This often leads to overexpression of the membrane serine protease fibroblast-activating protein (FAP). It has already been
Autor:
Saskia Roesch, Paul Flechsig, Michael Meister, Christel Herold-Mende, Annette Altmann, Anastasia Loktev, Max Sauter, Uwe Haberkorn, Thomas Lindner, Walter Mier
Publikováno v:
Molecular Imaging and Biology. 21:973-983
Targeted therapies are regarded as promising approaches to increase 5-year survival rate of non-small cell lung cancer (NSCLC) patients. Here, we investigated the clinical value of the αvβ6 integrin-specific peptide SFITGv6 as a diagnostic reagent
Autor:
Uwe Haberkorn, Jürgen Debus, Frederik L. Giesel, Frederik Marmé, Thomas Lindner, Walter Mier, Annette Altmann, Eva Maria Burger, Dirk Jäger, Anastasia Loktev, Clemens Kratochwil
Publikováno v:
Journal of Nuclear Medicine
Cancer-associated fibroblasts constitute a vital subpopulation of the tumor stroma and are present in more than 90% of epithelial carcinomas. The overexpression of the serine protease fibroblast activation protein (FAP) allows a selective targeting o
Autor:
Frederik L. Giesel, Sebastian Adeberg, Anastasia Loktev, Lisa Loi, Thomas Lindner, Hendrik Rathke, Daniel Paech, Uwe Haberkorn, Paul Windisch, Heinz Peter Schlemmer, Ralf Floca, Paul Flechsig, Clemens Kratochwil, Manuel Röhrich
Publikováno v:
European journal of radiology. 127
Objectives Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR
Autor:
Walter Mier, Manfred M. Marschalek, Frederik L. Giesel, Wencke Lehnert, Uwe Haberkorn, Paul Flechsig, Dirk Jäger, Thomas Lindner, Jürgen Debus, Clemens Kratochwil, Anastasia Loktev, Annette Altmann
Publikováno v:
Journal of Nuclear Medicine. 60:386-392
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts of several tumor entities. The recent development of quinoline-based PET tracers that act as FAP inhibitors (FAPIs) demonstrated promising results preclinically and
Autor:
Thomas, Lindner, Annette, Altmann, Susanne, Krämer, Christian, Kleist, Anastasia, Loktev, Clemens, Kratochwil, Frederik, Giesel, Walter, Mier, Frederik, Marme, Jürgen, Debus, Uwe, Haberkorn
Publikováno v:
J Nucl Med
Most epithelial tumors recruit fibroblasts and other nonmalignant cells and activate them into cancer-associated fibroblasts. This often leads to overexpression of the membrane serine protease fibroblast-activating protein (FAP). It has already been
Autor:
Gerhard Dyckhoff, Walter Mier, Paul Flechsig, Saskia Roesch, Annette Altmann, Uwe Haberkorn, Thomas Lindner, Anastasia Loktev, Rolf Warta, Christel Herold-Mende, Martin Müller, Max Sauter
Publikováno v:
Journal of Nuclear Medicine. 59:1679-1685
αvβ6 integrin is overexpressed by several carcinomas and thus considered a target for diagnostic imaging and anticancer therapies. Recently, we presented the αvβ6 integrin-binding peptide SFITGv6 as a novel potential tracer for imaging and target
Autor:
Frederik L. Giesel, Jürgen Debus, Clemens Kratochwil, Dirk Jäger, Thomas Lindner, Annette Altmann, Anastasia Loktev, Walter Mier, Uwe Haberkorn
Publikováno v:
Journal of Nuclear Medicine. 59:1415-1422
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis, chemotherapy resistance, and immunosuppression. Because FAP show
Autor:
Clemens Kratochwil, Jürgen Debus, Dirk Jäger, Annette Altmann, Christian Roumestand, Frederik L. Giesel, Uwe Haberkorn, Thomas Lindner, Anastasia Loktev, Philippe Barthe, Walter Mier
Publikováno v:
Journal of Nuclear Medicine
Journal of Nuclear Medicine, Society of Nuclear Medicine, 2018, 59 (9), pp.1423-1429. ⟨10.2967/jnumed.118.210435⟩
Journal of Nuclear Medicine, Society of Nuclear Medicine, 2018, 59 (9), pp.1423-1429. ⟨10.2967/jnumed.118.210435⟩
The tumor stroma, which accounts for a large part of the tumor mass, represents an attractive target for the delivery of diagnostic and therapeutic compounds. Here, the focus is notably on a subpopulation of stromal cells, known as cancer-associated