Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anastacia C. Berzat"'
Autor:
Channing J. Der, Adam Shutes, Emily J. Chenette, Carolyn Weinbaum, Janice E. Buss, Audrey Minden, Adrienne D. Cox, Anastacia C. Berzat
Publikováno v:
Journal of Biological Chemistry. 280:33055-33065
Wrch-1 is a Rho family GTPase that shares strong sequence and functional similarity with Cdc42. Like Cdc42, Wrch-1 can promote anchorage-independent growth transformation. We determined that activated Wrch-1 also promoted anchorage-dependent growth t
Publikováno v:
Current Biology. 14:2052-2056
Rho family GTPases are GDP/GTP-regulated molecular switches that regulate signaling pathways controlling diverse cellular processes [1, 2, 3]. Wrch-1 was identified as a Wnt-1 regulated Cdc42 homolog, upregulated by Wnt1 signaling in Wnt1-transformed
Autor:
Brian C. Capell, Michael R. Erdos, Francis S. Collins, James J. Fiordalisi, Trever G. Bivona, Channing J. Der, Ian M. Ahearn, Renee Varga, Mark R. Philips, Anastacia C. Berzat, Leslie B. Gordon, James P. Madigan, Steven E. Quatela, Adrienne D. Cox
Publikováno v:
The FASEB Journal. 20
Publikováno v:
Methods in enzymology. 406
The Rho family of GTPases comprises a major branch of the Ras superfamily of small GTPases. To date, at least 22 human members have been identified. However, most of our knowledge of Rho GTPase function comes from the study of the three classical Rho
The proper subcellular localization and biological activity of most Ras and Rho family small GTPases are dependent on their posttranslational modification by isoprenylation. Farnesyltransferase (FTase) and geranylgeranyl transferase I (GGTase I) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b55b684e64f6b6d19e40f0199ac570f
https://doi.org/10.1016/s0076-6879(05)07046-1
https://doi.org/10.1016/s0076-6879(05)07046-1
Publikováno v:
Methods (San Diego, Calif.). 37(2)
Modification of small GTPases by lipids is required for their proper subcellular localization and biological activity. Lipids added post-translationally include both farnesyl and geranylgeranyl isoprenoids and the fatty acid palmitate. Thus, specific