Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Anass Chiki"'
Autor:
Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson’s disease and other neur
Externí odkaz:
https://doaj.org/article/ccd4a55ef8a5402e84ee4c5adc02d9d4
Autor:
Frank Herrmann, Manuela Hessmann, Sabine Schaertl, Karola Berg-Rosseburg, Christopher J Brown, Galina Bursow, Anass Chiki, Andreas Ebneth, Miriam Gehrmann, Nicole Hoeschen, Madlen Hotze, Stefanie Jahn, Peter D Johnson, Vinod Khetarpal, Alex Kiselyov, Karsten Kottig, Stefanie Ladewig, Hilal Lashuel, Sven Letschert, Matthew R Mills, Kathrin Petersen, Michael E Prime, Christoph Scheich, Gerhard Schmiedel, John Wityak, Longbin Liu, Celia Dominguez, Ignacio Muñoz-Sanjuán, Jonathan A Bard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mH
Externí odkaz:
https://doaj.org/article/9ab72a1e5e324d34b23c0110b93bbd78
Autor:
Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
In Parkinson’s disease (PD) the monomeric protein alpha-synuclein (aSyn) misfolds and aggregates into insoluble fibrils. Here the authors use NMR measurements and hydrogen–deuterium exchange mass spectrometry and find that the more solvent expose
Externí odkaz:
https://doaj.org/article/06df908e29ff4c6a9479ca48a333babb
Autor:
Anass Chiki, Zhidian Zhang, Kolla Rajasekhar, Luciano A. Abriata, Iman Rostami, Lucien F. Krapp, Driss Boudeffa, Matteo Dal Peraro, Hilal A. Lashuel
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of the Huntingtin protein (Htt) have been shown to inhibit the aggregation and attenuate the toxicity of mutant Htt proteins in vitro and in various models of Huntington
Externí odkaz:
https://doaj.org/article/045b674b456b4b079baf7f9bee17020f
Autor:
Sonia Donzelli, Sinead A. OSullivan, Anne-Laure Mahul-Mellier, Ayse Ulusoy, Giuliana Fusco, Senthil T. Kumar, Anass Chiki, Johannes Burtscher, Manel L.D. Boussouf, Iman Rostami, Alfonso De Simone, Donato A. Di Monte, Hilal A. Lashuel
Increasing evidence points to post-translational modifications (PTMs) as key regulators of alpha-synuclein (α-Syn) function in health and disease. However, whether these PTMs occur before or after α-Syn pathology formation and their role in regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5651dfd62b2577e95098ccbd669b3236
https://doi.org/10.1101/2023.03.24.534149
https://doi.org/10.1101/2023.03.24.534149
Autor:
Madlen Hotze, Miriam Gehrmann, Manuela Hessmann, Longbin Liu, Christoph Scheich, Kathrin Petersen, Nicole Hoeschen, Peter Johnson, Sabine Schaertl, Stefanie Jahn, Matthew R. Mills, Ignacio Munoz-Sanjuan, Alex S. Kiselyov, John Wityak, Anass Chiki, Vinod Khetarpal, Karsten Kottig, Gerhard Schmiedel, Galina Bursow, Stefanie Ladewig, Christopher J. Brown, Karola Berg-Rosseburg, Michael Prime, Sven Letschert, Andreas Ebneth, Jonathan Bard, Celia Dominguez, Frank Herrmann, Hilal A. Lashuel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports
Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mHTT) under
Publikováno v:
Journal of the American Chemical Society. 144(24)
The lack of detailed insight into the structure of aggregates formed by the huntingtin protein (HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology formation in the brain of patients with Huntington's disease. To
Autor:
Ramanath Narayana Hegde, Andreas Reif, Anass Chiki, Hilal A. Lashuel, Driss Boudeffa, Jonathan Ricci, Luciano A. Abriata
Publikováno v:
Chembiochem
Post‐translational modifications (PTMs) within the first 17 amino acids (Nt17) of exon 1 of the Huntingtin protein (Httex1) play important roles in modulating its cellular properties and functions in health and disease. In particular, phosphorylati
Autor:
Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Alpha-synuclein (aSyn) within Lewy bodies, Lewy neurites, and other pathological hallmarks of Parkinson’s disease and synucleinopathies have consistently been shown to accumulate in aggregated and phosphorylated forms of the protein, predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece1a363e47d9f98b078b7ec801c4b5b
https://doi.org/10.1101/2022.03.30.486322
https://doi.org/10.1101/2022.03.30.486322
Autor:
David Eliezer, Galina Limorenko, Shifeng Xiao, Anass Chiki, Nadine Ait-Bouziad, Hilal A. Lashuel
Publikováno v:
The Journal of Biological Chemistry
The microtubule-associated protein Tau is implicated in the pathogenesis of several neurodegenerative disorders, including Alzheimer’s disease. Increasing evidence suggests that post-translational modifications play critical roles in regulating Tau